Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Thomas D. Hock"'
Publikováno v:
Gene. 540:62-67
NADPH oxidase 4 (NOX4) is a member of the NADPH oxidase gene family that regulates cellular differentiation, innate immunity and tissue fibrosis. Transforming growth factor-β (TGF-β1) is known to induce expression of NOX4 mRNA in mesenchymal cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506e526d600477f963a6ce0b060811e8
https://doi.org/10.1016/j.gene.2014.02.026
https://doi.org/10.1016/j.gene.2014.02.026
Publikováno v:
International Journal of Molecular Sciences; Volume 14; Issue 10; Pages: 19605-19617
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19605-19617 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 14, Iss 10, Pp 19605-19617 (2013)
International Journal of Molecular Sciences
Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by chronic inflammation and excessive collagen accumulation in the lung. Myofibroblasts are the primary collagen-producing cells in pulmonary fibrosis. Histone deacetylase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0824fba96413148db8d4ef2756f23e
https://doi.org/10.3390/ijms141019605
https://doi.org/10.3390/ijms141019605
Autor:
Jessy S. Deshane, Subhashini Bolisetty, Anupam Agarwal, Junghyun Kim, Nathalie Hill-Kapturczak, Thomas D. Hock
Publikováno v:
Journal of Biological Chemistry. 285:16476-16486
HO-1 (heme oxygenase-1) is an inducible microsomal enzyme that catalyzes the degradation of pro-oxidant heme. The goal of this study was to characterize a minimal enhancer region within the human HO-1 gene and delineate its role in modulating HO-1 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f78627449cb24ae31a6b9208ebfc016
https://doi.org/10.1074/jbc.m109.058586
https://doi.org/10.1074/jbc.m109.058586
Autor:
Norbert Leitinger, Anupam Agarwal, Bruce A. Freeman, Thomas D. Hock, Junghyun Kim, Marcienne M. Wright
Publikováno v:
Biochemical Journal. 422:353-361
Nitro-fatty acid products of oxidative inflammatory reactions mediate anti-inflammatory cell signalling responses. LNO 2 (nitrolinoleic acid) induces expression of HO-1 (haem oxygenase-1), an enzyme that catabolizes haem into products exhibiting pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f671a780140b4d5d3c03d8d988c1070
https://doi.org/10.1042/bj20090339
https://doi.org/10.1042/bj20090339
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F885-F894
Excess transforming growth factor-beta1 (TGF-beta1) in the kidney leads to increased cell proliferation and deposition of extracellular matrix, resulting in progressive kidney fibrosis. TGF-beta1, however, stabilizes and attenuates tissue injury thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b164435506ffe4c220c51658a8662c7
https://doi.org/10.1152/ajprenal.00519.2006
https://doi.org/10.1152/ajprenal.00519.2006
Autor:
Yukiko Honda, Michael B. Sporn, Andrew E. Place, Mark M. Yore, Nathalie Hill-Kapturczak, Gordon W. Gribble, Karen T. Liby, Thomas D. Hock, Nanjoo Suh, Charlotte R. Williams, Darlene B. Royce, Tadashi Honda, Renee Risingsong, Anupam Agarwal
Publikováno v:
Cancer Research. 65:4789-4798
The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivative 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im) are multifunctional molecules with potent antiproliferative, differentiating,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d15ff1df4246e80b7f719ad4305e751
https://doi.org/10.1158/0008-5472.can-04-4539
https://doi.org/10.1158/0008-5472.can-04-4539
Autor:
Ashish Kurundkar, Thomas D. Hock, Louise Hecker, Eric Meldrum, Victor J. Thannickal, Naomi J. Logsdon, Deepali Kurundkar, Yan Y. Sanders, Karen Bernard
Publikováno v:
Science translational medicine. 6(231)
The incidence and prevalence of pathological fibrosis increase with advancing age, although mechanisms for this association are unclear. We assessed the capacity for repair of lung injury in young (2 months) and aged (18 months) mice. Whereas the sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde573396fc682e58660b2dc7ca0fbae
https://pubmed.ncbi.nlm.nih.gov/25668226
https://pubmed.ncbi.nlm.nih.gov/25668226
Autor:
Ranu Surolia, Tong Ye, Jason S. Zolak, Purusotham Guroji, Suman Karki, Victor J. Thannickal, Ryan Duggal, Thomas D. Hock, Veena B. Antony
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(3)
Pleural mesothelial cells (PMCs), which are derived from the mesoderm, exhibit an extraordinary capacity to undergo phenotypic changes during development and disease. PMC transformation and trafficking has a newly defined role in idiopathic pulmonary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c071d169dea2b3f9b50305bb39782f
https://pubmed.ncbi.nlm.nih.gov/24265486
https://pubmed.ncbi.nlm.nih.gov/24265486
Publikováno v:
D108. OUT OF CONTROL: PROLIFERATIVE AND FIBROTIC REMODELING OF THE LUNG.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cbc0e5cae96463b6e18c688d0e26353
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6673
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6673
Publikováno v:
C68. OLD AND NEW PATHWAYS TO PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d9f0ff1f48ff892c61f955995cb52c
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4926
https://doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4926