Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Thomas D. Greenwood"'
1
Synthesis and anticonvulsant evaluation of some new 2-substituted-3-arylpyrido[2,3-d]pyrimidinones
Autor: Jeffrey R. Bloomquist, Thomas D. Greenwood, James F. Wolfe, Aaron L. Downey, David C. White
Publikováno v: Bioorganic & Medicinal Chemistry. 12:5711-5717
A series of 2-substituted-3-arylpyrido[2,3- d ]pyrimidinones was prepared for evaluation as potential anticonvulsants. In murine screening, compounds 4a – c having a 2-oxo-2-(4-pyridyl)ethyl group in the 2-position and a 2-substituted phenyl moiety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a7b2015d56a6c12ddbcf91a9c26c57
https://doi.org/10.1016/j.bmc.2004.07.068
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2
Photostimulated Reactions of Phenylacetic Acid Dianions with Aryl Halides. Influence of the Metallic Cation on the Regiochemistry of Arylation
Autor: Thomas D. Greenwood, James F. Wolfe, Godson C. Nwokogu, Jim-Wah Wong
Publikováno v: Organic Letters. 2:2643-2646
[reaction: see text]Phenylacetic acid dianions react via what appears to be an S(RN)1 process with aryl halides under photostimulation to afford aryl substitution products 5 and 6. When the counterion is K+, only 4-biphenylacetic acids 5 are obtained
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee1e9f0c69c815e826d0f0f8b6a5de6
https://doi.org/10.1021/ol006177f
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3
Synthesis of Succinimido[3,4-b]indane and 1,2,3,4,5,6-Hexahydro-1,5-methano-3-benzazocine-2,4-dione by Sequential Alkylation and Intramolecular Arylation of Enolates Derived from N,N,N‘N‘-Tetramethylbutanediamides and N,N,N‘N‘-Tetramethylpentanediamides
Autor: James M. Tanko, Joseph S. Merola, Stacey N. Greenwood, James F. Wolfe, Sushama A. Dandekar, Stéphane Mabic, Thomas D. Greenwood
Publikováno v: The Journal of Organic Chemistry. 64:1543-1553
The tricyclic title compounds, 4 and 5, were synthesized by initial alkylation of the lithium monoenolates of N,N,N‘,N‘-tetramethylbutanediamide (6) and N,N,N‘,N‘-tetramethylpentanediamide (19) with 2-iodobenzyl chloride in liquid NH3 at −6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bd3d5b2be0bba7ecf93a4bc44ffbf18
https://doi.org/10.1021/jo982000b
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4
Recent trends in the development of new anti-epileptic drugs
Autor: James F. Wolfe, Joyal M Mulheron, Thomas D. Greenwood
Publikováno v: Expert Opinion on Therapeutic Patents. 8:361-381
This article summarises reports of new compounds with anticonvulsant activity that have appeared in the patent literature over the past five years. The subject compounds are arranged and discussed according to the following two major categories: new
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c3817052ba9efa379db00879d53b47f
https://doi.org/10.1517/13543776.8.4.361
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5
Compatibility of Various Carbanion Nucleophiles with Heteroaromatic Nucleophilic Substitution by the SRN1 Mechanism
Autor: Jyothi S. Pisipati, Jim-Wah Wong, Godson C. Nwokogu, Thomas D. Greenwood, Kenneth J. Natalie, Patrick T. Flaherty, James F. Wolfe
Publikováno v: The Journal of Organic Chemistry. 62:6152-6159
Carbanions generated from 2,4,4-trimethyl-2-oxazoline (1a), 2-benzyl-4,4-dimethyl-2-oxazoline (1b), 2,4-dimethylthiazole (13a), 2-benzyl-4-methylthiazole (13b), N,N-dimethylacetamide (17a), tert-butyl acetate (17b), ethyl phenylacetate (17c), N-methy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df0dbf5097b61fa8b7888ee8d1fd2f20
https://doi.org/10.1021/jo962353f
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6
ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some New 3,6-Disubstituted 2-( 2-Oxo-2-(4-pyridyl)ethyl)-4(3H)-pyrimidinones
Autor: Thomas D. Greenwood, James F. Wolfe, James B. Campbell
Publikováno v: ChemInform. 23
To the Editor: In a recent paper we reported the synthesis and anticonvulsant properties of a series of new 2-substituted 3-aryl-4(3H)-quinazolinone analogues of 2 methyl-3-o-tolyl-4(3H)-quinazolinone (methaqualone). Preliminary screening of these co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5689692f3c727beaeea4f6de68b71aaa
https://doi.org/10.1002/chin.199221199
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8
Aromatic heteroannulation via metalation-cyclization of N-acyl-2-chlorobenzenesulfonamides and N-acylbenzenesulfonamides
Autor: Judith A. Lewis, Christine K. F. Hermann, James B. Campbell, James F. Wolfe, Thomas D. Greenwood
Publikováno v: The Journal of Organic Chemistry. 57:5328-5334
N-Acyl-2-chlorobenzenisulfonamides 7a-d undergo competitive metal-halogen exchange and ortho-deprotonation or α-deprotonation reactions when treated sequentially wiht sodium hydride and n-butyllithium. The o-lithio intermediates derived from metal-h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a063304d05ee7e71cc07c507dbb64c9
https://doi.org/10.1021/jo00046a012
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10
Synthesis of Succinimido[3,4-b]indane and 1,2,3,4,5,6-Hexahydro-1,5-methano-3-benzazocine-2,4-dione by Sequential Alkylation and Intramolecular Arylation of Enolates Derived from N,N,N'N'-Tetramethylbutanediamides and N,N,N'N'-Tetramethylpentanediamides
Autor: Sushama A., Dandekar, Stacey N., Greenwood, Thomas D., Greenwood, Stéphane, Mabic, Joseph S., Merola, James M., Tanko, James F., Wolfe
Publikováno v: The Journal of organic chemistry. 64(5)
The tricyclic title compounds, 4 and 5, were synthesized by initial alkylation of the lithium monoenolates of N,N,N',N'-tetramethylbutanediamide (6) and N,N,N',N'-tetramethylpentanediamide (19) with 2-iodobenzyl chloride in liquid NH(3) at -60 degree
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::366085da2a1e13ddd5fbb29c2a8a49eb
https://pubmed.ncbi.nlm.nih.gov/11674217
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