Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Thomas D. Gootz"'
Autor:
Thomas D Gootz
Publikováno v:
Critical Reviews™ in Immunology. 30:79-93
Amid the recent attention justly focused on the potential problem of microbial sources for weapons of bioterrorism, it is also apparent that human pathogens frequently isolated from infections in patients from community and hospital sources have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a367b17948ab626bf56e980efb2f40e
https://doi.org/10.1615/critrevimmunol.v30.i1.60
https://doi.org/10.1615/critrevimmunol.v30.i1.60
Autor:
Wen He, Brian Dougherty, Thomas D. Gootz, Richard C. Huard, Fadia Dib-Hajj, Phyllis Della-Latta, Mary Kay Lescoe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1998-2004
Carbapenem-resistant Klebsiella strains carrying Klebsiella pneumoniae carbapenemases (KPC) are endemic to New York City and are spreading across the United States and internationally. Recent studies have indicated that the KPC structural gene is loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a06f8262dcd0c8814d7f1d33dbd924
https://doi.org/10.1128/aac.01355-08
https://doi.org/10.1128/aac.01355-08
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:3396-3406
Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug resistant) are being isolated from some hospitals in New York City with increasing frequency. A highly related pair of K. pneumoniae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9aefe23c3b877f069ed8ec2c5e283e5
https://doi.org/10.1128/aac.00285-06
https://doi.org/10.1128/aac.00285-06
Autor:
Thomas D. Gootz
Publikováno v:
Biochemical Pharmacology. 71:1073-1084
Gram-negative bacilli have become increasingly resistant to antibiotics over the past 2 decades due to selective pressure from the extensive use of antibiotics in the hospital and community. In addition, these bacteria have made optimum use of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ddef91559c77770535c8f7dc0e1c3b
https://doi.org/10.1016/j.bcp.2005.11.006
https://doi.org/10.1016/j.bcp.2005.11.006
Autor:
Frank S. Kaczmarek, Thomas D. Gootz, Shawn Hallowell, Melissa Cronan, Wenchi Shang, Fadia Dib-Hajj
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:1630-1639
Previous studies with beta-lactamase-negative, ampicillin-resistant (BLNAR) Haemophilus influenzae from Japan, France, and North America indicate that mutations in ftsI encoding PBP3 confer ampicillin MICs of 1 to 4 μg/ml. Several BLNAR strains with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8045827ed98223df3ee3bf7e57e96971
https://doi.org/10.1128/aac.48.5.1630-1639.2004
https://doi.org/10.1128/aac.48.5.1630-1639.2004
Autor:
Thomas D. Gootz
Publikováno v:
Expert Review of Anti-infective Therapy. 2:317-327
While the main era of beta-lactam discovery programs is over, these agents continue to be the most widely prescribed antimicrobials in both community and hospital settings. This has led to considerable beta-lactam pressure on pathogens, resulting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5503a9d1620fb1f945f3948dbf67ba2b
https://doi.org/10.1586/14787210.2.2.317
https://doi.org/10.1586/14787210.2.2.317
Autor:
Neil Osheroff, Thomas D. Gootz
Publikováno v:
Quinolone Antimicrobial Agents
This chapter reviews the literature with respect to the reported effects of quinolones on topoisomerase II in vitro and considers those reports relevant to the effects of quinolones on whole cells. The initial part of the chapter describes in more de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82673aae81faa499de2f86884b52f8bb
https://doi.org/10.1128/9781555817817.ch4
https://doi.org/10.1128/9781555817817.ch4
Cloning and Functional Characterization of an NAD + -Dependent DNA Ligase from Staphylococcus aureus
Autor:
Dongxu Sun, Patrick K. Martin, Melissa Cronan, Bret Benton, Matt Griffor, Ajith V. Kamath, Thomas D. Gootz, Donald P. Biek, Mahmoud N. Mansour, Laura McDowell, John P. Mueller, Richard P. Zaniewski, Dennis E. Danley, Molly B. Schmid, Frank S. Kaczmarek
Publikováno v:
Journal of Bacteriology. 183:3016-3024
A Staphylococcus aureus mutant conditionally defective in DNA ligase was identified by isolation of complementing plasmid clones that encode the S. aureus lig A gene. Orthologues of the putative S. aureus NAD + -dependent DNA ligase could be identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bc90111aa0159c0182f1967b57c0be
https://doi.org/10.1128/jb.183.10.3016-3024.2001
https://doi.org/10.1128/jb.183.10.3016-3024.2001
Autor:
Virginia E. Anderson, Frank S. Kaczmarek, Thomas D. Gootz, Neil Osheroff, Richard P. Zaniewski
Publikováno v:
Biochemistry. 39:2726-2732
Topoisomerase IV is the primary cellular target for most quinolones in Gram-positive bacteria; however, its interaction with these agents is poorly understood. Therefore, the effects of four clinically relevant antibacterial quinolones (ciprofloxacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a17548a4245b01fa0f09e0cfb0bbd4
https://doi.org/10.1021/bi992302n
https://doi.org/10.1021/bi992302n
Autor:
Richard P. Zaniewski, Frank S. Kaczmarek, Virginia E. Anderson, Neil Osheroff, Thomas D. Gootz
Publikováno v:
Journal of Biological Chemistry. 274:35927-35932
Quinolones are the most active oral antibacterials in clinical use and act by increasing DNA cleavage mediated by prokaryotic type II topoisomerases. Although topoisomerase IV appears to be the primary cytotoxic target for most quinolones in Gram-pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b7f65291041ccf2b36a7acf093ce82
https://doi.org/10.1074/jbc.274.50.35927
https://doi.org/10.1074/jbc.274.50.35927