Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thomas D. Friedrich"'
Autor:
Lydia E. Hainley, Martina S. Hughson, Amithi Narendran, Ralph Smith, Justin Arthur, Alida Hayner-Buchan, David J. Conti, John M. Lehman, Thomas D. Friedrich
Publikováno v:
Viruses, Vol 13, Iss 7, p 1353 (2021)
The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation. If left unchecked, BK polyomavirus nephropathy (PyVAN) and possible graft loss may
Externí odkaz:
https://doaj.org/article/e1be5ee50af8442ea856442e9a43f861
Autor:
Thomas D. Friedrich, David J. Conti, Lydia E Hainley, Amithi Narendran, Justin Arthur, Alida Hayner-Buchan, John M. Lehman, Ralph L. Smith, Martina S Hughson
Publikováno v:
Viruses
Volume 13
Issue 7
Viruses, Vol 13, Iss 1353, p 1353 (2021)
Volume 13
Issue 7
Viruses, Vol 13, Iss 1353, p 1353 (2021)
The human BK polyomavirus (BKPyV) is latent in the kidneys of most adults, but can be reactivated in immunosuppressed states, such as following renal transplantation. If left unchecked, BK polyomavirus nephropathy (PyVAN) and possible graft loss may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9c6782141d0021318ea9682584a5c6
https://doi.org/10.3390/v13071353
https://doi.org/10.3390/v13071353
Autor:
Pascal Reisewitz, Sayuri Ando, Tetsuya Kurata, Tsuyoshi Aoyama, Hironori Deguchi, Thomas D. Friedrich, Mitsuyasu Hasebe, Wolfgang Werr, Tomoaki Nishiyama, Yosuke Tamada, Yuji Hiwatashi, Masaki Ishikawa, Thomas Laux, Takashi Murata, Yoshikatsu Sato, Keiko Sakakibara, Stefan A. Rensing
Publikováno v:
Development. 141:1660-1670
Many differentiated plant cells can dedifferentiate into stem cells, reflecting the remarkable developmental plasticity of plants. In the moss Physcomitrella patens, cells at the wound margin of detached leaves become reprogrammed into stem cells. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe752d68fb0b9275d9df344f06cfeebb
https://doi.org/10.1242/dev.097444
https://doi.org/10.1242/dev.097444
Autor:
Douglas B. Kitchen, Svetlana Dobritsa, Mei Bai, Thomas D. Friedrich, Peter R. Guzzo, Grant J. Carr, Mark A. Wolf, Michael A. Lynch, Alexander Usyatinsky, Russell J. DeOrazio, Denise Peace, Kevin Fitzpatrick, Mohammed Sajad
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3017-3020
An indazole based series of glucocorticoid receptor agonists is reported. The SAR exploration of this scaffold yielded compounds with nanomolar affinity for the glucocorticoid receptor with indications of selectivity for the preferred transrepression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf658724c2cf779a78fc64c6106b32be
https://doi.org/10.1016/j.bmcl.2010.04.012
https://doi.org/10.1016/j.bmcl.2010.04.012
Autor:
Michael P. Trova, Keith D. Barnes, Curt Barford, Travis Benanti, Mark Bielaska, Lori Burry, John M. Lehman, Christine Murphy, Harold O’Grady, Denise Peace, Susan Salamone, Jennifer Smith, Patricia Snider, Joseph Toporowski, Steven Tregay, Alison Wilson, Michael Wyle, Xiaozhang Zheng, Thomas D. Friedrich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6608-6612
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b74222a35c5b64e239a7140455c1dba
https://doi.org/10.1016/j.bmcl.2009.10.025
https://doi.org/10.1016/j.bmcl.2009.10.025
Autor:
Susan Salamone, Steven Tregay, Brian I. Bliss, Michael P. Trova, Simon Haydar, Joseph Anthony Bilotta, Luis Alicea, Patricia Snider, Matthew P. Rainka, R. Jason Herr, Xiaozhang Zheng, Denise Peace, Thuy Nguyen Duong, Keith D. Barnes, Travis Benanti, Thomas D. Friedrich, Matthew R. Johnson, Mark Bielaska, Yu Hui, John M. Lehman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6613-6617
The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc9ed62ae30c61b43e5febf5164cc35
https://doi.org/10.1016/j.bmcl.2009.10.011
https://doi.org/10.1016/j.bmcl.2009.10.011
Autor:
Michael S. Hemenway, Joseph O. Rich, Kevin G. Pattamana, Peter C. Michels, Zhicai Yang, Simon Haydar, Jun-Ho Maeng, Frederic Bois, Thomas D. Friedrich, Bruce F. Molino, Yeyu Cao, Denise Peace, Yuri L. Khmelnitsky
Publikováno v:
Synlett. 2009:2935-2938
Cyclosporin A (CsA) was converted into cyclosporin methyl vinyl ketone (Cs-MVK) by either a biocatalytic method utilizing 1-hydroxybenzotriazole-mediated laccase oxidation or by a chemical oxidation using t-butyl hydroperoxide and potassium periodate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93acdb0c4422525327cbb95d99237689
https://doi.org/10.1055/s-0029-1218011
https://doi.org/10.1055/s-0029-1218011
Publikováno v:
Cytometry Part A. :10-18
Background Simian Virus 40 (SV40) infection of growth-arrested monkey kidney cells stimulates S phase entry and the continued synthesis of both viral and cellular DNA. Infected cells can attain total DNA contents as high as DNA Index, DI = 5.0–6.0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4291b38ef5e9d29700004779570f52
https://doi.org/10.1002/cyto.a.20185
https://doi.org/10.1002/cyto.a.20185
Publikováno v:
Experimental Cell Research. 251:121-127
The infection of monkey kidney (CV-1) cells with simian virus 40 (SV40) stimulates the cells into successive rounds of DNA synthesis without an intervening mitosis, leading to the acquisition of a >G2 DNA content. To elucidate the role of small t ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162fa2d07c26b06c4ce7ddff52734c9a
https://doi.org/10.1006/excr.1999.4572
https://doi.org/10.1006/excr.1999.4572
Publikováno v:
Cytometry. 31:260-264
Simian virus 40 (SV40) infection of quiescent monkey kidney cells stimulates two successive rounds of cellular DNA synthesis without an intervening mitosis. This uncoupling of S phase and mitosis indicates that SV40 modulates pathways regulating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b38f3dd7051ad531b11fc58cc901f7bb
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<260::aid-cyto5>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19980401)31:4<260::aid-cyto5>3.0.co