Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas D. Baird"'
Autor:
Thomas D Baird, Ken Chih-Chien Cheng, Yu-Chi Chen, Eugen Buehler, Scott E Martin, James Inglese, J Robert Hogg
Publikováno v:
eLife, Vol 7 (2018)
The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5–10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by
Externí odkaz:
https://doaj.org/article/7ecc3ea4baf745df9eca9cfa37e05400
Autor:
J. Robert Hogg, Thomas D Baird
Publikováno v:
mRNA Decay ISBN: 9781493975396
Cellular mRNA levels are determined by the competing forces of transcription and decay. A wide array of cellular mRNA decay pathways carry out RNA turnover either on a constitutive basis or in response to changing cellular conditions. Here, we outlin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db0aca8b0f3b8022fa827b738a648be
https://doi.org/10.1007/978-1-4939-7540-2_12
https://doi.org/10.1007/978-1-4939-7540-2_12
Autor:
James Inglese, Yu-Chi Chen, Ken Chih-Chien Cheng, J. Robert Hogg, Thomas D Baird, Scott E. Martin, Eugen Buehler
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5–10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceba947f5a3972165c4f8b3e9b8155e8
https://pubmed.ncbi.nlm.nih.gov/29528287
https://pubmed.ncbi.nlm.nih.gov/29528287
Autor:
Jeanette N. McClintick, Thomas D. Baird, Lakshmi Reddy Palam, Jeffrey A. Willy, Ronald C. Wek, Tracy G. Anthony, Michael E. Fusakio, Christopher M. Davis
Publikováno v:
Molecular Biology of the Cell
This study measured changes in global mRNA translation in response to ER stress. The analysis suggests that translation of a majority of gene transcripts is either repressed or resistant, whereas select key regulators are subject to preferential tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb3c50852e91b3366e8b9a035201794
https://doi.org/10.1091/mbc.e14-02-0704
https://doi.org/10.1091/mbc.e14-02-0704
Publikováno v:
The Journal of biological chemistry. 291(20)
In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein synthesis while concomitantly promoting preferential translation of specific transcripts associated with stress adaptation. Translation of the glutamyl-prolyl-tRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4aae2b21d66d4d05c13b51b0fdc02
https://pubmed.ncbi.nlm.nih.gov/27002157
https://pubmed.ncbi.nlm.nih.gov/27002157
Autor:
Thomas D. Baird, Ronald C. Wek
Publikováno v:
Advances in Nutrition. 3:307-321
Regulation of mRNA translation is a rapid and effective means to couple changes in the cellular environment with global rates of protein synthesis. In response to stresses, such as nutrient deprivation and accumulation of misfolded proteins in the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aad580a9a8726e2214f07a6aa4b619d
https://doi.org/10.3945/an.112.002113
https://doi.org/10.3945/an.112.002113
Autor:
Hongzhen He, Ronald C. Wek, Millie M. Georgiadis, Isha Singh, Sheree A. Wek, Souvik Dey, Thomas D. Baird
Publikováno v:
The Journal of biological chemistry. 289(21)
In response to amino acid starvation, GCN2 phosphorylation of eIF2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress. GCN2 is a multidomain protein with key regulatory domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d183bdb2b62aa7f300b9a6edc44b2ea1
https://pubmed.ncbi.nlm.nih.gov/24719324
https://pubmed.ncbi.nlm.nih.gov/24719324
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16b7280e5c2bafe3dfa1f3740ffde093
https://doi.org/10.1096/fasebj.27.1_supplement.551.10
https://doi.org/10.1096/fasebj.27.1_supplement.551.10
In response to different environmental stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synthesis, which lowers energy expenditure and facilitates reprogramming of gene expression to remediate stress damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0975d71a96ecd6150dbc64e55ae148
https://europepmc.org/articles/PMC3064149/
https://europepmc.org/articles/PMC3064149/