Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas D Southgate"'
Autor:
Thomas D Southgate, Owen J McGinn, Fernanda V Castro, Andrzej J Rutkowski, Mariam Al-Muftah, Georgi Marinov, Graeme J Smethurst, David Shaw, Christopher M Ward, Crispin J Miller, Peter L Stern
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9982 (2010)
5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryoni
Externí odkaz:
https://doaj.org/article/241e25236e374b98aa8b044b9f332cd1
Autor:
Peter L. Stern, Sai Daayana, Richard Harrop, David J Sherlock, Deborah J. Burt, Adam Dangoor, Jan W. Drijfhout, Thomas D. Southgate, Eyad Elkord, Robert E. Hawkins
Publikováno v:
Cancer Immunology, Immunotherapy. 58:1657-1667
We have recently reported the results of a phase II trial in which two TroVax [modified vaccinia ankara (MVA) encoding the tumour antigen 5T4] vaccinations were given to patients both pre- and post-surgical resection of liver metastases secondary to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdbea778e66183b5deb2810cfff8e0d
https://doi.org/10.1007/s00262-009-0674-y
https://doi.org/10.1007/s00262-009-0674-y
Publikováno v:
British Medical Bulletin. 85:17-33
Alkylating agents are frequently used in the chemotherapy of many types of cancer. This group of drugs mediates cell death by damaging DNA and therefore, understandably, cellular DNA repair mechanisms can influence both their antitumour efficacy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc93d7fc3837b60a3b7baba242b6ac8
https://doi.org/10.1093/bmb/ldm036
https://doi.org/10.1093/bmb/ldm036
Publikováno v:
Gene Therapy. 13:602-610
Antibody-dependent cellular cytotoxicity (ADCC) is one means by which macrophages (as well as natural killer cells and granulocytes) elicit a cytotoxic response. This is achieved via interaction of the Fc-gamma-receptor (CD64) with the Fc portion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69d3820b52ca8c033fa79b88eb187f3
https://doi.org/10.1038/sj.gt.3302706
https://doi.org/10.1038/sj.gt.3302706
Autor:
Leslie J. Fairbairn, Geoffrey P. Margison, Thomas D. Southgate, Michael D. Milsom, Lorna B. Woolford
Publikováno v:
The Journal of Gene Medicine. 8:29-34
The O(6)-methylguanine-DNA-methyltransferase (MGMT) inactivator O(6)-benzylguanine (O(6)-beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac805d77bc17da593960b2dce0260443
https://doi.org/10.1002/jgm.816
https://doi.org/10.1002/jgm.816
Publikováno v:
Expert Reviews in Molecular Medicine. 6:1-24
The haematopoietic system can be manipulated genetically to increase either its resistance to drugs or its sensitivity to certain agents. Gene transfer and expression of specific drug-resistance factors might protect haematopoietic function during an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8724cad60cbe1d7070ef1bd8a68b74f
https://doi.org/10.1017/s146239940400818x
https://doi.org/10.1017/s146239940400818x
Publikováno v:
Trends in Endocrinology & Metabolism. 12:58-64
The main objectives of pituitary tumour treatment are to restore normal function of the pituitary gland and prevent tumour recurrences. In spite of the success of current therapies in the treatment of relatively small tumours, new therapeutic alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bc203773d1941c35ff991d36bab2bd
https://doi.org/10.1016/s1043-2760(00)00358-1
https://doi.org/10.1016/s1043-2760(00)00358-1
Autor:
H. Anne Simmonds, Adrian E. Morelli, Thomas D. Southgate, Pedro R. Lowenstein, Maria G. Castro, Adriana T. Larregina, Lynette D. Fairbanks, D. Bain
Publikováno v:
Metabolic Brain Disease. 14:205-221
The Lesch-Nyhan syndrome is an X-linked disorder caused by a virtually complete absence of the key enzyme of purine recycling, hypoxanthine-guanine phosphoribosyltransferase (HPRT). It is characterized by uric acid overproduction and severe neurologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::974c5be7b95aa6d48f0b77344617aa13
https://doi.org/10.1023/a:1020728924026
https://doi.org/10.1023/a:1020728924026
Publikováno v:
The journal of gene medicine. 11(2)
Background We proposed to exploit hypoxia-inducible factor (HIF)-1α overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF-1α to arrange
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4025fd93aca2dd724c480b1e5483c22
https://pubmed.ncbi.nlm.nih.gov/19051213
https://pubmed.ncbi.nlm.nih.gov/19051213
