Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Thomas D Pugh"'
Autor:
Jamie L Barger, Rozalyn M Anderson, Michael A Newton, Cristina da Silva, James A Vann, Thomas D Pugh, Shinichi Someya, Tomas A Prolla, Richard Weindruch
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120738 (2015)
Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers un
Externí odkaz:
https://doaj.org/article/979cd6779f6848da91ee85328ec8a68f
Autor:
Steven M. Wood, Richard Weindruch, Nicole L. Cray, Shelly N. Hester, Jamie L. Barger, Tomas A. Prolla, Angela Mastaloudis, James M. Vann, Michael A. Newton, Thomas D. Pugh
Publikováno v:
Aging Cell
Summary Caloric restriction (CR) without malnutrition has been shown to retard several aspects of the aging process and to extend lifespan in different species. There is strong interest in the identification of CR mimetics (CRMs), compounds that mimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6958163803b571316cf80761c2f8707
https://doi.org/10.1111/acel.12608
https://doi.org/10.1111/acel.12608
Autor:
Ricki J. Colman, Stephen A. Martin, Rozalyn M. Anderson, Karl N. Miller, Timothy Mark Beasley, Kevin W. Eliceiri, Sterling C. Johnson, Michael A. Polewski, Tyler M. DeMuth, Thomas D. Pugh
Publikováno v:
Aging Cell
Summary The hippocampus is critical for cognition and memory formation and is vulnerable to age‐related atrophy and loss of function. These phenotypes are attenuated by caloric restriction (CR), a dietary intervention that delays aging. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8596c7bc706ace8ad6b152b096cd1a7f
https://doi.org/10.1111/acel.12418
https://doi.org/10.1111/acel.12418
Publikováno v:
Experimental Gerontology. 43:859-866
An active area of aging research is focused on identifying compounds having the ability to mimic the effects of caloric restriction (CR). From 2 to 5 months of age, we fed male B6C3F(1) mice either a 40% CR diet, a control diet supplemented with a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46919e1548725ac5af38ba908681b2a0
https://doi.org/10.1016/j.exger.2008.06.013
https://doi.org/10.1016/j.exger.2008.06.013
Autor:
Tatsuya Yamasoba, Thomas D. Pugh, Shinichi Someya, Masaru Tanokura, Gregory C. Kujoth, Richard Weindruch, Tomas A. Prolla
Publikováno v:
Neurobiology of Aging. 29:1080-1092
Mitochondrial DNA (mtDNA) mutations may contribute to aging and age-related diseases. Previously, we reported that accumulation of mtDNA mutations is associated with age-related hearing loss in mice carrying a mutator allele of the mitochondrial Polg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7becff281cfbf078282baf26c9b53f
https://doi.org/10.1016/j.neurobiolaging.2007.01.014
https://doi.org/10.1016/j.neurobiolaging.2007.01.014
Autor:
Rozalyn M. Anderson, Jamie L. Barger, Richard Weindruch, Cristina da Silva, James A. Vann, Shinichi Someya, Thomas D. Pugh, Michael A. Newton, Tomas A. Prolla
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0120738 (2015)
PLoS ONE, Vol 10, Iss 4, p e0120738 (2015)
Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4252236f9f43cfd126db0a24d8bd88
http://europepmc.org/articles/PMC4382298
http://europepmc.org/articles/PMC4382298
Autor:
Thomas D. Pugh, Grier P. Page, Tomas A. Prolla, Yoshikazu Higami, David B. Allison, Richard Weindruch
Publikováno v:
The FASEB Journal. 18:1-26
We investigated the influences of short-term and lifespan-prolonging long-term caloric restriction (LCR) on gene expression in white adipose tissue (WAT). Over 11,000 genes were examined using high-density oligonucleotide microarrays in four groups o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae30a52e4d6f71273113c35df178821
https://doi.org/10.1096/fj.03-0678fje
https://doi.org/10.1096/fj.03-0678fje
Autor:
N. Ung, Anne M. Bronikowski, Thomas D. Pugh, Richard Weindruch, Theodore J. Morgan, Tomas A. Prolla, Patrick A. Carter, Theodore Garland
Publikováno v:
Physiological Genomics. 12:129-138
We present the first quantitative gene expression analysis of cardiac aging under conditions of sedentary and active lifestyles using high-density oligonucleotide arrays representing 11,904 cDNAs and expressed sequence tags (ESTs). With these data, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc040014ac8f58a4f680c3a7dc2dcc4
https://doi.org/10.1152/physiolgenomics.00082.2002
https://doi.org/10.1152/physiolgenomics.00082.2002
Publikováno v:
The Prostate. 33:256-263
BACKGROUND. Caloric restriction (CR) retards aging and diseases in mice, rats, and other animals by unknown mechanisms. A popular hypothesis is that CR acts by opposing age-associated increases in oxidative stress. METHODS. Because influences of CR o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d73b1b2af219db99bfe5d276e0d74f51
https://doi.org/10.1002/(sici)1097-0045(19971201)33:4<256::aid-pros6>3.0.co
https://doi.org/10.1002/(sici)1097-0045(19971201)33:4<256::aid-pros6>3.0.co
Autor:
T. Mark Beasley, Rachelle Pass, Ricki J. Colman, Matthew W. Conklin, Patricia J. Keely, Rozalyn M. Anderson, Richard Weindruch, Bradley D. Anderson, Trent D. Evans, Hannah J. Barbian, Thomas D. Pugh, Michael A. Polewski, Kevin W. Eliceiri
Age-associated skeletal muscle mass loss curtails quality of life and may contribute to defects in metabolic homeostasis in older persons. The onset of sarcopenia occurs in middle age in rhesus macaques although the trigger has yet to be identified.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8501e985588f5d8a5fdc26e029bf42ef
https://europepmc.org/articles/PMC3714309/
https://europepmc.org/articles/PMC3714309/
