Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Thomas D Pfister"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1e13a844305b46c8a3c72e5c9590fd2c
Autor:
Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199361 (2018)
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents fo
Externí odkaz:
https://doaj.org/article/f5177b4e279648b6b9d11f4b1381c950
Autor:
Thomas D Pfister, Melinda Hollingshead, Robert J Kinders, Yiping Zhang, Yvonne A Evrard, Jiuping Ji, Sonny A Khin, Suzanne Borgel, Howard Stotler, John Carter, Raymond Divelbiss, Shivaani Kummar, Yves Pommier, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50494 (2012)
Topoisomerase I (Top1) is a proven target for cancer therapeutics. Recent data from the Fluorouracil, Oxaliplatin, CPT-11: Use and Sequencing (FOCUS) trial demonstrated that nuclear staining of Top1 correlates with chemotherapeutic efficacy. Such a c
Externí odkaz:
https://doaj.org/article/fc45c0d607034df99dbf3dba3216402a
Autor:
Robert J. Kinders, James H. Doroshow, Joseph E. Tomaszewski, Anthony J. Murgo, Martin E. Gutierrez, Yvonne A. Evrard, Larry Rubinstein, Shivaani Kummar, Ralph E. Parchment, Thomas D. Pfister, Lihua H. Wang
Purpose: Circulating tumor cells (CTC) in peripheral blood of patients potentially represent a fraction of solid tumor cells available for more frequent pharmacodynamic assessment of drug action than is possible using tumor biopsy. However, currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60a236e106e8634cb694f012d26d42f
https://doi.org/10.1158/1078-0432.c.6519651
https://doi.org/10.1158/1078-0432.c.6519651
Autor:
Ralph E. Parchment, James H. Doroshow, Joseph E. Tomaszewski, W. Marston Linehan, Donald P. Bottaro, Robert J. Kinders, Thomas D. Pfister, Suzanne Borgel, Yiping Zhang, Jiuping Jay Ji, Sonny A. Khin, Yvonne A. Evrard, Tony Navas, Jennifer Weiner, Melinda G. Hollingshead, Apurva K. Srivastava
Table S1: Summary of analytical characteristics of full-length MET and pMET assays; data collected from assays run with A549, U87, SNU5 and GTL-16 xenograft tumor extracts. Table S2: Measurement of MET and pMET levels in core needle specimens (#1-5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4275f2dc106338b0968102684ac3aa
https://doi.org/10.1158/1078-0432.22457915
https://doi.org/10.1158/1078-0432.22457915
Autor:
Yves Pommier, James H. Doroshow, Joseph E. Tomaszewski, Ralph E. Parchment, Robert J. Kinders, Sonny A. Khin, Shalu Gupta, Keli Agama, William C. Reinhold, Thomas D. Pfister
Supplementary Materials from Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96372251957696df91443b758b8f1a1d
https://doi.org/10.1158/1535-7163.22485447.v1
https://doi.org/10.1158/1535-7163.22485447.v1
Autor:
Ralph E. Parchment, James H. Doroshow, Joseph E. Tomaszewski, W. Marston Linehan, Donald P. Bottaro, Robert J. Kinders, Thomas D. Pfister, Suzanne Borgel, Yiping Zhang, Jiuping Jay Ji, Sonny A. Khin, Yvonne A. Evrard, Tony Navas, Jennifer Weiner, Melinda G. Hollingshead, Apurva K. Srivastava
Purpose: Rational development of targeted MET inhibitors for cancer treatment requires a quantitative understanding of target pharmacodynamics, including molecular target engagement, mechanism of action, and duration of effect.Experimental Design: Sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cc82bee0797ee2f6ea9a7f0342ca11
https://doi.org/10.1158/1078-0432.c.6523751
https://doi.org/10.1158/1078-0432.c.6523751
Autor:
Yves Pommier, James H. Doroshow, Joseph E. Tomaszewski, Ralph E. Parchment, Robert J. Kinders, Sonny A. Khin, Shalu Gupta, Keli Agama, William C. Reinhold, Thomas D. Pfister
Topoisomerase I (Top1) is a proven target for cancer therapeutics, and the level of Top1 in tumors has been used as a biomarker for chemotherapeutic efficacy. In this study, we report the development and validation of a two-site enzyme chemiluminesce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c9110b51fb94819b35ad70cb68bc11
https://doi.org/10.1158/1535-7163.c.6531945.v1
https://doi.org/10.1158/1535-7163.c.6531945.v1
Autor:
Ralph E. Parchment, James H. Doroshow, Joseph E. Tomaszewski, W. Marston Linehan, Donald P. Bottaro, Robert J. Kinders, Thomas D. Pfister, Suzanne Borgel, Yiping Zhang, Jiuping Jay Ji, Sonny A. Khin, Yvonne A. Evrard, Tony Navas, Jennifer Weiner, Melinda G. Hollingshead, Apurva K. Srivastava
Figure S1: Specificity of the MET antibodies demonstrated by Western blot analysis. Figure S2: Effect of freeze-thaw cycles and warm vs cold ischemia time on full-length and pMET levels. Figure S3: Inhibition of tumor growth and intratumoral MET phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113c03dc6f2ba086a30ec3d69a8cc619
https://doi.org/10.1158/1078-0432.22457912.v1
https://doi.org/10.1158/1078-0432.22457912.v1
Autor:
Yves Pommier, John N. Weinstein, James Doroshow, Ralph Parchment, Robert Kinders, Thomas D. Pfister, Michael Ryan, Hongfang Liu, Jean-Louis Mergny, William C. Reinhold
Supplementary Figure 1 from Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03aa06f57472f0d05a389d150cc8e65
https://doi.org/10.1158/0008-5472.22387517.v1
https://doi.org/10.1158/0008-5472.22387517.v1