Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Thomas D Petes"'
Autor:
Lei Qi, Yang Sui, Xing-Xing Tang, Ryan J McGinty, Xiao-Zhuan Liang, Margaret Dominska, Ke Zhang, Sergei M Mirkin, Dao-Qiong Zheng, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010590 (2023)
Although homologous recombination between transposable elements can drive genomic evolution in yeast by facilitating chromosomal rearrangements, the details of the underlying mechanisms are not fully clarified. In the genome of the yeast Saccharomyce
Externí odkaz:
https://doaj.org/article/e2c144da17f64f8f9a508562b585b3cc
Publikováno v:
eLife, Vol 6 (2017)
In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule. I
Externí odkaz:
https://doaj.org/article/441ded87ce644f0a8ef77f38d9e618c5
Autor:
Sabrina L Andersen, Aimee Zhang, Margaret Dominska, María Moriel-Carretero, Emilia Herrera-Moyano, Andrés Aguilera, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005938 (2016)
The Saccharomyces cerevisae RAD3 gene is the homolog of human XPD, an essential gene encoding a DNA helicase of the TFIIH complex involved in both nucleotide excision repair (NER) and transcription. Some mutant alleles of RAD3 (rad3-101 and rad3-102)
Externí odkaz:
https://doaj.org/article/4e34bf8082464838a446ffdf70d09c2b
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005098 (2015)
Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. F
Externí odkaz:
https://doaj.org/article/17f23bbbec0c4b55942d65b12302244e
Autor:
Yi Yin, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005026 (2015)
DNA lesions caused by UV radiation are highly recombinogenic. In wild-type cells, the recombinogenic effect of UV partially reflects the processing of UV-induced pyrimidine dimers into DNA gaps or breaks by the enzymes of the nucleotide excision repa
Externí odkaz:
https://doaj.org/article/d9d72eb0b7ea4af793869aa6f64bbccc
Autor:
Yi Yin, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003894 (2013)
In the yeast Saccharomyces cerevisiae and most other eukaryotes, mitotic recombination is important for the repair of double-stranded DNA breaks (DSBs). Mitotic recombination between homologous chromosomes can result in loss of heterozygosity (LOH).
Externí odkaz:
https://doaj.org/article/024d28ccf6c047139c193c36175fa180
Autor:
Jordan St Charles, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003434 (2013)
Although homologous recombination is an important pathway for the repair of double-stranded DNA breaks in mitotically dividing eukaryotic cells, these events can also have negative consequences, such as loss of heterozygosity (LOH) of deleterious mut
Externí odkaz:
https://doaj.org/article/722b005f90aa479faa05beac2d1f9b71
Autor:
Wei Tang, Margaret Dominska, Patricia W Greenwell, Zachary Harvanek, Kirill S Lobachev, Hyun-Min Kim, Vidhya Narayanan, Sergei M Mirkin, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 7, Iss 1, p e1001270 (2011)
Expansions of trinucleotide GAA•TTC tracts are associated with the human disease Friedreich's ataxia, and long GAA•TTC tracts elevate genome instability in yeast. We show that tracts of (GAA)(230)•(TTC)(230) stimulate mitotic crossovers in yeas
Externí odkaz:
https://doaj.org/article/59adf8cdebcf42908eafed207a85a711
Autor:
Phoebe S Lee, Patricia W Greenwell, Margaret Dominska, Malgorzata Gawel, Monica Hamilton, Thomas D Petes
Publikováno v:
PLoS Genetics, Vol 5, Iss 3, p e1000410 (2009)
Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas
Externí odkaz:
https://doaj.org/article/bf248ebbb82946d3a0e29a1a76d46f24
Publikováno v:
PLoS Genetics, Vol 4, Iss 6, p e1000105 (2008)
The ribosomal DNA (rDNA) genes of Saccharomyces cerevisiae are located in a tandem array of about 150 repeats. Using a diploid with markers flanking and within the rDNA array, we showed that low levels of DNA polymerase alpha elevate recombination be
Externí odkaz:
https://doaj.org/article/d3382a0917cd4f4c983d5582515f50fd