Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Thomas D Otto"'
Autor:
Clare Andradi-Brown, Jan Stephan Wichers-Misterek, Heidrun von Thien, Yannick D Höppner, Judith AM Scholz, Helle Hansson, Emma Filtenborg Hocke, Tim Wolf Gilberger, Michael F Duffy, Thomas Lavstsen, Jake Baum, Thomas D Otto, Aubrey J Cunnington, Anna Bachmann
Publikováno v:
eLife, Vol 12 (2024)
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorp
Externí odkaz:
https://doaj.org/article/ee63f3338efa4b578bd3c5c0608fd5e0
Publikováno v:
eLife, Vol 12 (2023)
African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the mammal and tsetse fly midgut, respectively. This allows them to colonise the host environment upon infection and ensure life cycle progression. Yet, understanding
Externí odkaz:
https://doaj.org/article/a6e797bbc6474bdf9c9e3e732d0581df
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1009975 (2022)
Cell-cell interactions are vital for numerous biological processes including development, differentiation, and response to inflammation. Currently, most methods for studying interactions on scRNA-seq level are based on curated databases of ligands an
Externí odkaz:
https://doaj.org/article/f5dff1b316724d358d95b46b9389885a
Autor:
J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schöllhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, Anna Bachmann
Publikováno v:
eLife, Vol 10 (2021)
Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis
Externí odkaz:
https://doaj.org/article/d3b8e2993ebe43d09af293580efc8d04
Autor:
Megan A Sloan, Karen Brooks, Thomas D Otto, Mandy J Sanders, James A Cotton, Petros Ligoxygakis
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008452 (2019)
Trypanosomatid parasites are causative agents of important human and animal diseases such as sleeping sickness and leishmaniasis. Most trypanosomatids are transmitted to their mammalian hosts by insects, often belonging to Diptera (or true flies). Th
Externí odkaz:
https://doaj.org/article/b03d4b6d59894a04943e952542573b36
Autor:
Stefano Pegoraro, Maëlle Duffey, Thomas D Otto, Yulin Wang, Roman Rösemann, Roland Baumgartner, Stefanie K Fehler, Leonardo Lucantoni, Vicky M Avery, Alicia Moreno-Sabater, Dominique Mazier, Henri J Vial, Stefan Strobl, Cecilia P Sanchez, Michael Lanzer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Severe malaria is a life-threatening infection with limited treatment options. Here, using a medicinal chemistry approach starting from amicarbalide, Pegoraroet al. identify a compound that, when delivered intravenously, can cure Plasmodium falciparu
Externí odkaz:
https://doaj.org/article/31209cc459aa4f289ae53a99dad149ad
Autor:
Abdallah M Abdallah, Eveline M Weerdenburg, Qingtian Guan, Roy Ummels, Stephanie Borggreve, Sabir A Adroub, Tareq B Malas, Raeece Naeem, Huoming Zhang, Thomas D Otto, Wilbert Bitter, Arnab Pain
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211003 (2019)
The mycobacterial type VII secretion system ESX-1 is responsible for the secretion of a number of proteins that play important roles during host infection. The regulation of the expression of secreted proteins is often essential to establish successf
Externí odkaz:
https://doaj.org/article/f34212ee8a7f4fe08eb2f2189dbf0663
Autor:
Susana Campino, Alejandro Marin-Menendez, Alison Kemp, Nadia Cross, Laura Drought, Thomas D Otto, Ernest Diez Benavente, Matt Ravenhall, Frank Schwach, Gareth Girling, Magnus Manske, Michel Theron, Kelda Gould, Eleanor Drury, Taane G Clark, Dominic P Kwiatkowski, Alena Pance, Julian C Rayner
Publikováno v:
PLoS Pathogens, Vol 14, Iss 11, p e1007436 (2018)
Invasion of human erythrocytes is essential for Plasmodium falciparum parasite survival and pathogenesis, and is also a complex phenotype. While some later steps in invasion appear to be invariant and essential, the earlier steps of recognition are c
Externí odkaz:
https://doaj.org/article/9e05168788a948c78df1cbed1e547a93
Autor:
Aude Gilabert, Thomas D Otto, Gavin G Rutledge, Blaise Franzon, Benjamin Ollomo, Céline Arnathau, Patrick Durand, Nancy D Moukodoum, Alain-Prince Okouga, Barthélémy Ngoubangoye, Boris Makanga, Larson Boundenga, Christophe Paupy, François Renaud, Franck Prugnolle, Virginie Rougeron
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006035 (2018)
Although Plasmodium vivax is responsible for the majority of malaria infections outside Africa, little is known about its evolution and pathway to humans. Its closest genetic relative, P. vivax-like, was discovered in African great apes and is hypoth
Externí odkaz:
https://doaj.org/article/3ff05e46b51f4265ba2c21cecd34f79e
Autor:
Aurélie Fougère, Andrew P Jackson, Dafni Paraskevi Bechtsi, Joanna A M Braks, Takeshi Annoura, Jannik Fonager, Roberta Spaccapelo, Jai Ramesar, Séverine Chevalley-Maurel, Onny Klop, Annelies M A van der Laan, Hans J Tanke, Clemens H M Kocken, Erica M Pasini, Shahid M Khan, Ulrike Böhme, Christiaan van Ooij, Thomas D Otto, Chris J Janse, Blandine Franke-Fayard
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006128 (2017)
[This corrects the article DOI: 10.1371/journal.ppat.1005917.].
Externí odkaz:
https://doaj.org/article/c2c38d1a6c904cbaac48c2316a158103