Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.

Autor: Valérie Mongrain, Francesco La Spada, Thomas Curie, Paul Franken

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26622 (2011)

We have previously demonstrated that clock genes contribute to the homeostatic aspect of sleep regulation. Indeed, mutations in some clock genes modify the markers of sleep homeostasis and an increase in homeostatic sleep drive alters clock gene expr

Externí odkaz: https://doaj.org/article/5c1ded53fbab46529e5729f1ff5e702d

Homeostatic and Circadian Contribution to EEG and Molecular State Variables of Sleep Regulation

Autor: Paul Franken, Stéphane Dorsaz, Valérie Mongrain, Thomas Curie, Yann Emmenegger, Géraldine M. Mang

Publikováno v: Sleep. 36:311-323

Study Objectives: Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca86fdb53fd267e693f5f6e53580297
https://doi.org/10.5665/sleep.2440

Separating the Contribution of Glucocorticoids and Wakefulness to the Molecular and Electrophysiological Correlates of Sleep Homeostasis

Autor: Susana A. Hernandez, Thomas Curie, Grace Hagiwara, Sylvain Pradervand, Stéphane Dorsaz, Phung Gip, Paul Franken, Valérie Mongrain, H. Craig Heller

Publikováno v: Sleep. 33:1147-1157

The sleep-deprivation-induced changes in delta power, an electroencephalographical correlate of sleep need, and brain transcriptome profiles have importantly contributed to current hypotheses on sleep function. Because sleep deprivation also induces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138caa88787d0a17b2d2b3af7f9c638a
https://doi.org/10.1093/sleep/33.9.1147

The systemic control of circadian gene expression

Autor: Yann Emmenegger, Pascal Gos, Alan Gerber, Ueli Schibler, Thomas Curie, Paul Franken, Camille Saini, Ivana Gotic, Pauline Gosselin, Gianpaolo Rando

Publikováno v: Gerber, A, Saini, C, Curie, T, Emmenegger, Y, Rando, G, Gosselin, P, Gotic, I, Gos, P, Franken, P & Schibler, U 2015, ' The systemic control of circadian gene expression ', Diabetes, Obesity and Metabolism, vol. 17, no. S1, pp. 23-32 . https://doi.org/10.1111/dom.12512
Diabetes Obes Metab
Diabetes Obesity and Metabolism

The mammalian circadian timing system consists of a central pacemaker in the brain's suprachiasmatic nucleus (SCN) and subsidiary oscillators in nearly all body cells. The SCN clock, which is adjusted to geophysical time by the photoperiod, synchroni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fec4afa3cc6d5546d90b7d501bdce39
https://pubmed.ncbi.nlm.nih.gov/26332965

Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks

Autor: Andre Liani, Yann Emmenegger, Camille Saini, Yves Alain Poget, Luigi Bonacina, Florian Kreppel, Ulrich Schibler, Jean-Pierre Wolf, Pascal Gos, Paulus Franken, Thomas Curie

Publikováno v: Genes and Development, Vol. 27, No 13 (2013) pp. 1526-1536
Genes & Development

The mammalian circadian timing system consists of a master pacemaker in the suprachiasmatic nucleus (SCN) in the hypothalamus, which is thought to set the phase of slave oscillators in virtually all body cells. However, due to the lack of appropriate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2556a60f38ac6b198fd09da641fcc421
https://pubmed.ncbi.nlm.nih.gov/23824542