Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas Charles Malone"'
Autor:
Daniel F. Ortwine, Peter A. Boxer, Leonard Joseph Lescosky, S. A. Borosky, Daniel Martin Retz, C.B. Nelson, Thomas Charles Malone, Christopher F. Bigge, Mark G. Vartanian, Schelkun Robert Michael
Publikováno v:
Journal of Medicinal Chemistry. 38:3720-3740
Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists with potential as neuroprotective agents, primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe1f78653faecd9283d29ff86e0bbd8
https://doi.org/10.1021/jm00019a003
https://doi.org/10.1021/jm00019a003
Autor:
Thomas Charles Malone, Gregory W. Campbell, Elsebet Ø. Nielsen, Peter A. Boxer, Jorgen Drejer, Christopher F. Bigge, Frank Wätjen, Frank W. Marcoux, David M. Rock, Leif Helth Jensen, Leonard Joseph Lescosky, Linda L. Coughenour
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:371-376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8c346721d74ca36cf753dffe53bc279
https://doi.org/10.1016/s0960-894x(01)80147-5
https://doi.org/10.1016/s0960-894x(01)80147-5
Publikováno v:
Current Opinion on Therapeutic Patents. 3:951-989
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64b91a6f372408974b784d4770ea90d6
https://doi.org/10.1517/13543776.3.7.951
https://doi.org/10.1517/13543776.3.7.951
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:49-54
The syntheses, biological activity, and molecular modeling of conformationally constrained derivatives of cis-1,3,4,9,19,10a-hexahydro-N-methyl-4a(2H)-phenanthreneamine (PD 134365), a new conformationally rigid noncompetitive N-methyl-D-aspartate (NM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f23170bd38a6fcd144b82cdd98d35909
https://doi.org/10.1016/s0960-894x(00)80090-6
https://doi.org/10.1016/s0960-894x(00)80090-6
Autor:
Christopher F. Bigge, Thomas Charles Malone, Mark G. Vartanian, Charles Taylor, Jiang-Ping Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:39-42
The (+)- and (−)-enantiomers of 1,2,3,4-tetrahydro-5-(2-phosphonoethyl)-3-isoquinoline-carboxylic acid ( 12 and 13 ) were prepared. The anticonvulsant activity of 12 and 13 and their parent ( 14 ) was compared to the reference agent, CPP, in the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405dfedef369c50b6f8ec8f79b19431a
https://doi.org/10.1016/s0960-894x(00)80088-8
https://doi.org/10.1016/s0960-894x(00)80088-8
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c377f3cdc57744c0380d899486205fb
https://doi.org/10.1002/chin.199144187
https://doi.org/10.1002/chin.199144187
Autor:
Daniel F. Ortwine, James T. Drummond, Thomas Charles Malone, Christine Humblet, Graham Johnson, Garry W. Pinter, Christopher F. Bigge
Publikováno v:
ChemInform. 24
The preparation and binding affinity of a series of tetrahydroisoquinoline carboxylic acids at the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is described, together with a molecular modeling analysis of NMDA agonists and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2804fa13caec29d5a3ecc7c0827fa13e
https://doi.org/10.1002/chin.199301225
https://doi.org/10.1002/chin.199301225
Autor:
Leonard Joseph Lescosky, Peter A. Boxer, Christopher F. Bigge, E. Oe. Nielen, Thomas Charles Malone, David M. Rock, Gregory W. Campbell, Frank W. Marcoux, F. Waetjen, L. H. Jensen, J. Drejer, Linda L. Coughenour
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c38063053e43445d1cf35f12d1ae9f8
https://doi.org/10.1002/chin.199427105
https://doi.org/10.1002/chin.199427105
Autor:
Mark G. Vartanian, Gregory W. Campbell, Christopher F. Bigge, Daniel F. Ortwine, Roy D. Schwarz, Peter A. Boxer, Schelkun Robert Michael, Lillian J. Robichaud, S. A. Borosky, D. M. Retz, Thomas Charles Malone, Leonard Joseph Lescosky, F. Waetjen, C.B. Nelson
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba446b1cb6d0230e4edfbb4863c69962
https://doi.org/10.1002/chin.199603167
https://doi.org/10.1002/chin.199603167
Autor:
Daniel F. Ortwine, Christine Humblet, Graham Johnson, Garry W. Pinter, James T. Drummond, Christopher F. Bigge, Thomas Charles Malone
Publikováno v:
Journal of Medicinal Chemistry. 35:1345-1370
The preparation and binding affinity of a series of tetrahydroisoquinoline carboxylic acids at the N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is described, together with a molecular modeling analysis of NMDA agonists and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8129eae8b303259bdc7219836433ba6c
https://doi.org/10.1021/jm00086a004
https://doi.org/10.1021/jm00086a004