Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Thomas C. Williams"'
Autor:
Tiina Talts, Lucy G. Mosscrop, David Williams, John S. Tregoning, Whitney Paulo, Arinder Kohli, Thomas C. Williams, Katja Hoschler, Joanna Ellis, Simon de Lusignan, Maria Zambon
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTPrevention of respiratory syncytial virus (RSV) infection is now a global health priority, with a long-acting monoclonal antibody and two RSV vaccines recently licenced for clinical use. Most licenced and candidate interventions target the RS
Externí odkaz:
https://doaj.org/article/b3898c91b7de4407be54ac9d4b238011
Autor:
Mario Hönemann, Melanie Maier, Armin Frille, Stephanie Thiem, Sandra Bergs, Thomas C. Williams, Vicente Mas, Christoph Lübbert, Corinna Pietsch
Publikováno v:
Viruses, Vol 16, Iss 6, p 943 (2024)
Following an interseasonal rise in mainly pediatric respiratory syncytial virus (RSV) cases in Germany in 2021, an exceptionally high number of adult cases was observed in the subsequent respiratory season of 2022/2023. The aim of this study was to c
Externí odkaz:
https://doaj.org/article/d0a9393445e348e8ad8a2dfc2ff3197d
Autor:
Alexander C. Carpenter, Adam M. Feist, Fergus S.M. Harrison, Ian T. Paulsen, Thomas C. Williams
Publikováno v:
Metabolic Engineering Communications, Vol 17, Iss , Pp e00227- (2023)
Adaptive Laboratory Evolution (ALE) is a powerful tool for engineering and understanding microbial physiology. ALE relies on the selection and enrichment of mutations that enable survival or faster growth under a selective condition imposed by the ex
Externí odkaz:
https://doaj.org/article/9cda84a8ff8247b3962bd063e0d29514
Autor:
Xin Xu, Felix Meier, Benjamin A. Blount, Isak S. Pretorius, Tom Ellis, Ian T. Paulsen, Thomas C. Williams
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Naturally evolved genomes tend to be unnecessarily large and redundant, and are not optimised for biotechnological or research applications. In this review, the authors explore genome minimization and re-functionalisation approaches, and discuss thei
Externí odkaz:
https://doaj.org/article/b48e29581c2f49e99b9a9fd76a69f807
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Long-duration human space travel creates challenges for maintaining healthy diets. Here the authors discuss using synthetic biology approaches to modify yeast into an optimal, and enjoyable, food production platform.
Externí odkaz:
https://doaj.org/article/2dbe2cba2b804ff28e25ef64f17a908f
Autor:
Dariusz R. Kutyna, Cristobal A. Onetto, Thomas C. Williams, Hugh D. Goold, Ian T. Paulsen, Isak S. Pretorius, Daniel L. Johnson, Anthony R. Borneman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The Sc2.0 consortia is reengineering the yeast genome. To expand the Sc2.0 genetic repertoire, the authors build a neo-chromosome comprising variable loci from diverse yeast isolates, providing phenotypic plasticity for use in synthetic backgrounds.
Externí odkaz:
https://doaj.org/article/aaf51d0b12724b23b5230f82efc00ed9
Autor:
Vahid Salimi, Mariana Viegas, Alfonsina Trento, Charles N. Agoti, Larry J. Anderson, Vasanthi Avadhanula, Justin Bahl, Louis Bont, J. Rodney Brister, Patricia A. Cane, Mónica Galiano, Barney S. Graham, Eneida L. Hatcher, Orienka Hellferscee, David M. Henke, Siddhivinayak Hirve, Sandra Jackson, Els Keyaerts, Leyla Kragten-Tabatabaie, Stephen Lindstrom, Inne Nauwelaers, D. James Nokes, Peter J. Openshaw, Teresa C. Peret, Pedro A. Piedra, Kaat Ramaekers, Annabel Rector, Nídia Sequeira Trovão, Anne von Gottberg, Maria Zambon, Wenqing Zhang, Thomas C. Williams, Ian G. Barr, Ursula J. Buchholz
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 6, Pp 1-9 (2021)
Human respiratory syncytial virus (HRSV) is the leading viral cause of serious pediatric respiratory disease, and lifelong reinfections are common. Its 2 major subgroups, A and B, exhibit some antigenic variability, enabling HRSV to circulate annuall
Externí odkaz:
https://doaj.org/article/59ac1599330b4f9f938b24bfd4509f55
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Synthetic metagenomics could potentially unravel the complexities of microbial ecosystems by revealing the simplicity of microbial communities captured in a single cell. Conceptionally, a yeast cell carrying a representative synthetic metagenome coul
Externí odkaz:
https://doaj.org/article/d0d1a8e7750f45338af64eda6f23ac15
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Synthetic biology engineering principles enable two-way communication between living and inanimate substrates. Here the authors consider the development of this bio-informational exchange and propose cyber-physical architectures and applications.
Externí odkaz:
https://doaj.org/article/d5f5456f74344ed1b96e6a8cc8e12176
Autor:
Monica I. Espinosa, Ricardo A. Gonzalez-Garcia, Kaspar Valgepea, Manuel R. Plan, Colin Scott, Isak S. Pretorius, Esteban Marcellin, Ian T. Paulsen, Thomas C. Williams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Methylotrophic metabolism enables growth on methanol, an alternative to sugar fermentation. Here the authors use adaptive laboratory evolution to uncover native methylotrophy capacity in Saccharomyces cerevisiae.
Externí odkaz:
https://doaj.org/article/1dcbdbecd52142a095554b4b3fa33939