Gene expression profiling of U2AF2 dependent RNA-protein interactions during CD4+ T cell activation

Autor: Thomas C Whisenant

Publikováno v: Genomics Data, Vol 11, Iss C, Pp 77-80 (2017)

CD4 T cell activation is a central component of the mammalian adaptive immune response and is underscored by a dramatic change in the gene expression profile in these cells. The changes in gene expression that occur during T cell activation are regul

Externí odkaz: https://doaj.org/article/3101247d9e8c464dae2f21fe7b5ec870

Supplementary Figures and Tables from Irreversible Electroporation Combined with Checkpoint Blockade and TLR7 Stimulation Induces Antitumor Immunity in a Murine Pancreatic Cancer Model

Autor: Rebekah R. White, Stephen P. Schoenberger, Aaron M. Miller, Dennis A. Carson, Diego Vicente, Thomas C. Whisenant, Tomoko Hayashi, Partha Ray, Jayanth S. Shankara Narayanan

Supplementary Figures 1-6 and Supplementary Tables 1 and 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b24330db0f7104b12d2e2b07c4eb19
https://doi.org/10.1158/2326-6066.22542112.v1

Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells

Autor: Inge van der Werf, Phoebe K. Mondala, S. Kathleen Steel, Larisa Balaian, Luisa Ladel, Cayla N. Mason, Raymond H. Diep, Jessica Pham, Jacqueline Cloos, Gertjan J.L. Kaspers, Warren C. Chan, Adam Mark, James J. La Clair, Peggy Wentworth, Kathleen M. Fisch, Leslie A. Crews, Thomas C. Whisenant, Michael D. Burkart, Mary E. Donohoe, Catriona H.M. Jamieson

Publikováno v: Cell reports. Medicine, vol 4, iss 3
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962

Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635fc2f87ba6c7bb45c6b2245e0c70ae
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150286973&origin=inward

Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation.

Autor: April N Meyer, Leandro H Gallo, Juyeon Ko, Guillermo Cardenas, Katelyn N Nelson, Asma Siari, Alexandre R Campos, Thomas C Whisenant, Daniel J Donoghue

Publikováno v: PLoS ONE, Vol 13, Iss 10, p e0206014 (2018)

Mutations at position K171 in the kinase activation loop of Inhibitor of κB kinase beta (IKKβ) occur in multiple myeloma, spleen marginal zone lymphoma and mantle cell lymphoma. Previously, we demonstrated that these result in constitutive kinase a

Externí odkaz: https://doaj.org/article/7f375f0c173943949633ebeaa9b17bf7

Reversal of malignant ADAR1 splice isoform switching with Rebecsinib

Autor: Leslie A. Crews, Wenxue Ma, Luisa Ladel, Jessica Pham, Larisa Balaian, S. Kathleen Steel, Phoebe K. Mondala, Raymond H. Diep, Christina N. Wu, Cayla N. Mason, Inge van der Werf, Isabelle Oliver, Eduardo Reynoso, Gabriel Pineda, Thomas C. Whisenant, Peggy Wentworth, James J. La Clair, Qingfei Jiang, Michael D. Burkart, Catriona H.M. Jamieson

Publikováno v: Cell Stem Cell. 30:250-263.e6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::479f480adc67d87af29db08fbda10b67
https://doi.org/10.1016/j.stem.2023.01.008