Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Thomas C. Vanaman"'
Autor:
Sidney W. Whiteheart, Greg A. Gerhardt, Seth R. Batten, Thomas C. Vanaman, Elena A. Matveeva, John T. Slevin
Publikováno v:
Brain and Behavior
Introduction In kindling, repeated electrical stimulation of certain brain areas causes progressive and permanent intensification of epileptiform activity resulting in generalized seizures. We focused on the role(s) of glutamate and a negative regula
Autor:
John T. Slevin, Thomas C. Vanaman, David A. Price, Elena A. Matveeva, Sidney W. Whiteheart, Greg A. Gerhardt
Publikováno v:
Neuroscience. 202:77-86
Our previous work has correlated permanent alterations in the rat neurosecretory machinery with epileptogenesis. Such findings highlighted the need for a greater understanding of the molecular mechanisms underlying epilepsy so that novel therapeutic
Autor:
Thomas C. Vanaman, Verda A. Davis, John T. Slevin, Sidney W. Whiteheart, Greg A. Gerhardt, Elena A. Matveeva
Publikováno v:
Epilepsia. 53:157-167
SUMMARY Purpose—To correlate kindling-associated alterations of the neurotransmitter secretory machinery, glutamate release in the trisynaptic hippocampal excitatory pathway, and the behavioral evolution of kindling-induced epileptogenesis. Method
Publikováno v:
Epilepsy Research. 73:266-274
Modifications of neurotransmission may contribute to the synchronization of neuronal networks that are a hallmark of epileptic seizures. In this study we examine the synaptosomal proteins involved in neurotransmitter release to determine if alteratio
Autor:
Thomas C. Vanaman, Paul C. Brandt
Publikováno v:
Journal of Neurochemistry. 62:799-802
The regulation of intracellular calcium is essential for proper muscle function. Muscle cells have several mechanisms for dealing with the rapid and large changes in cytosolic calcium level that occur during contraction. Among these is the plasma mem
Autor:
Paul C. Brandt, Thomas C. Vanaman
Publikováno v:
Journal of Biological Chemistry. 275:24534-24539
We have previously shown that inhibition of expression of the plasma membrane Ca(2+)-ATPase isoform 1 in PC6 cells leads to loss of nerve growth factor-mediated neurite extension (Brandt, P.C., Sisken, J.E., Neve, R.L., and Vanaman, T.C. (1996) Proc.
Autor:
Paul C. Brandt, John J. Franks, Thomas C. Vanaman, Piotr K. Janicki, Artur W. Wamil, W. T. Franks, Victoria E. Janson, Jean-Louis Horn
Publikováno v:
Anesthesiology. 89:149-164
Background Many inhalation anesthetics at clinically relevant concentrations inhibit plasma membrane Ca2+-adenosine triphosphatase (PMCA) ion pumping in brain synaptic membranes and in cultured cells of neural origin. In this study, the authors inves
Analysis of plasma membrane Ca2+-ATPase expression in control and SV40-transformed human fibroblasts
Publikováno v:
Cell Calcium. 21:53-62
It has been long known that neoplastic transformation is accompanied by a lowered requirement for extracellular Ca2+ for growth. The studies presented here demonstrate that human fibroblastic cell lines produce the two commonly found 'housekeeping' i
Autor:
Carolyn Pratt Brock, Thomas C. Vanaman, David S. Watt, M. A. Lloyd, Miroslaw Golinski, Paul J. DeLaLuz
Publikováno v:
Acta Crystallographica Section B Structural Science. 52:713-719
The structures of three nitro-substituted phenothiazines [1,3,4-trifluoro-2-nitrophenothiazine, 10-(4-chlorobutyl)-1,3,4-trifluoro-2-nitrophenothiazine and 10-(4-chlorobutyl)-3-nitrophenothiazine] have been determined. The first of these red compound
Publikováno v:
Bioconjugate Chemistry. 6:558-566
The biotinylated probe, 3-azido-10-(4-(4-biotinyl-1-piperazinyl)butyl)phenothiazine, was used to examine the phenothiazine binding domains in calmodulin (CaM) by photolabeling. This phenothiazine, synthesized from 3-azido-10-(4-(1-piperazinyl)butyl)p