Identifying dysregulated immune cell subsets following volumetric muscle loss with pseudo-time trajectories

Autor: Lauren A. Hymel, Shannon E. Anderson, Thomas C. Turner, William Y. York, Hongmanlin Zhang, Adrian R. Liversage, Hong Seo Lim, Peng Qiu, Luke J. Mortensen, Young C. Jang, Nick J. Willett, Edward A. Botchwey

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Abstract Volumetric muscle loss (VML) results in permanent functional deficits and remains a substantial regenerative medicine challenge. A coordinated immune response is crucial for timely myofiber regeneration, however the immune response following

Externí odkaz: https://doaj.org/article/e9aea08ec0a142578a9a1de39ac7156d

Improving hard palate wound healing using immune modulatory autotherapies

Autor: Samir A. Ballestas, Yvonne C. Stephenson, Archana Kamalakar, Thomas C. Turner, Nick J. Willett, Edward A. Botchwey, Steven L. Goudy

Publikováno v: Acta Biomater

Oral cavity wound healing occurs in an environment that sustains ongoing physical trauma and is rich in bacteria. Despite this, injuries to the mucosal surface often heal faster than cutaneous wounds and leave less noticeable scars. Patients undergoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df717d22c265df53b057e71beaf9f4c3
https://doi.org/10.1016/j.actbio.2019.04.052

Harnessing lipid signaling pathways to target specialized pro-angiogenic neutrophil subsets for regenerative immunotherapy

Autor: Gabriel A. Kwong, Hong Seo Lim, F. S. Pittman, Thomas C. Turner, Edward A. Botchwey, Quoc D. Mac, William Y. York, Peng Qiu, Mary Caitlin P. Sok, L. A. Hymel, S. Vyshnya

Publikováno v: Science Advances

Local delivery of a pro-resolving lipid mediator leads to a shift in the immune microenvironment and improves wound healing.
To gain insights into neutrophil heterogeneity dynamics in the context of sterile inflammation and wound healing, we per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052347bd70bc4d4549f089c887785765
http://europepmc.org/articles/PMC7608810

Modulating local S1P receptor signaling as a regenerative immunotherapy after volumetric muscle loss injury

Autor: Shannon E. Anderson, Claire E. Olingy, Edward A. Botchwey, Alan Y. Liu, L. A. Hymel, Hong Seo Lim, Sraeyes Sridhar, Cheryl L. San Emeterio, Young C. Jang, Thomas C. Turner, William Y. York, Todd Sulchek, Nick J. Willett, Molly E. Ogle, Peng Qiu

Publikováno v: J Biomed Mater Res A

Regeneration of skeletal muscle after volumetric injury is thought to be impaired by a dysregulated immune microenvironment that hinders endogenous repair mechanisms. Such defects result in fatty infiltration, tissue scarring, chronic inflammation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d9b9def10124659d9e0948750d5e4a
https://pubmed.ncbi.nlm.nih.gov/32608188

Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches

Autor: Jennifer L. Wilson, Milton L. Brown, Hannah Song, Parker H. Merrill, Scott M. Capitosti, Anusuya Das, Mary Caitlin P. Sok, Mikell Paige, Edward A. Botchwey, Brandon Freshcorn, Thomas C. Turner

Publikováno v: Regenerative engineering and translational medicine
Springer International Publishing
Regenerative engineering and translational medicine, vol 5, iss 1

Control of microvascular network growth is critical to treatment of ischemic tissue diseases and enhancing regenerative capacity of tissue engineering implants. Conventional therapeutic strategies for inducing angiogenesis aim to deliver one or more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90b55a6c366c669b63f4f7f540bb4cd
https://doi.org/10.1007/s40883-018-0077-8