Zobrazeno 1 - 10
of 292
pro vyhledávání: '"Thomas C. Spelsberg"'
Autor:
Min Li, Wei Xu, Yinxia Zhao, Lin Wei, Jing Guo, Hongkai Zhang, Xuelian Wang, Yahui Song, Lie Wang, Yuan Luo, Malayannan Subramaniam, Jie Yang, Thomas C. Spelsberg
Publikováno v:
Cell Mol Immunol
Viral myocarditis (VMC) is a cardiac disease associated with myocardial inflammation and injury induced by virus infection. Cardiomyocytes have recently been regarded as key players in eliciting and modulating inflammation within the myocardium. Krup
Autor:
Anne Gingery, Malayannan Subramaniam, Kevin S Pitel, Jordan M Reese, Muzaffer Cicek, Laurence B Lindenmaier, James N Ingle, Matthew P Goetz, Russell T Turner, Urszula T Iwaniec, Thomas C Spelsberg, John R Hawse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98219 (2014)
Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells
Externí odkaz:
https://doaj.org/article/67822f0f26c34e9d85cce6b81062378a
Autor:
John R Hawse, Malayannan Subramaniam, Muzaffer Cicek, Xianglin Wu, Anne Gingery, Sarah B Grygo, Zhifu Sun, Kevin S Pitel, Wilma L Lingle, Matthew P Goetz, James N Ingle, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54613 (2013)
Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being
Externí odkaz:
https://doaj.org/article/53b65588edee4aa2a677eafd0d4587e4
Autor:
John R Hawse, Muzaffer Cicek, Sarah B Grygo, Elizabeth S Bruinsma, Nalini M Rajamannan, Andre J van Wijnen, Jane B Lian, Gary S Stein, Merry Jo Oursler, Malayannan Subramaniam, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19429 (2011)
Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (K
Externí odkaz:
https://doaj.org/article/c3b2d29944cd4ce390182c32fdb11d6f
Autor:
Muzaffer Cicek, Anne Vrabel, Catherine Sturchio, Larry Pederson, John R Hawse, Malayannan Subramaniam, Thomas C Spelsberg, Merry Jo Oursler
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17522 (2011)
TGF-β Inducible Early Gene-1 (TIEG1) is a Krüppel-like transcription factor (KLF10) that was originally cloned from human osteoblasts as an early response gene to TGF-β treatment. As reported previously, TIEG1(-/-) mice have decreased cortical bon
Externí odkaz:
https://doaj.org/article/08f87d151b71472e8234f49a058e9ead
Autor:
Thomas C. Spelsberg
Publikováno v:
Chromosomal Nonhistone Proteins ISBN: 9781351070676
Chromosomal Nonhistone Proteins
Chromosomal Nonhistone Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b7a1b104be0a6a49e1a96d56036b486
https://doi.org/10.1201/9781351070676-3
https://doi.org/10.1201/9781351070676-3
Autor:
Jie Yang, Xuelian Wang, Zhanghong Kai, Jing Guo, Lin Wei, Yahui Song, Yinxia Zhao, Yuan Luo, Malayannan Subramaniam, Thomas C. Spelsberg, Lie Wang, Wei Xu, Min Li
Publikováno v:
SSRN Electronic Journal.
Autor:
Kevin S. Pitel, John R. Hawse, Kenneth A. Philbrick, Vera J. Suman, Russell T. Turner, Muzaffer Cicek, Farhan A. Syed, Thomas C. Spelsberg, James N. Ingle, Malayannan Subramaniam, Urszula T. Iwaniec, Kenneth D Peters, Anne Gingery
Publikováno v:
Journal of Bone and Mineral Research. 29:1206-1216
TGFβ Inducible Early Gene-1 (TIEG1) knockout (KO) mice display a sex-specific osteopenic phenotype characterized by low bone mineral density, bone mineral content, and overall loss of bone strength in female mice. We, therefore, speculated that loss
Autor:
Xianglin Wu, Muzaffer Cicek, Malayannan Subramaniam, Carol Reynolds, Matthew P. Goetz, Vivian Negron, James N. Ingle, Wilma L. Lingle, Thomas C. Spelsberg, John R. Hawse
Publikováno v:
Journal of Cellular Biochemistry. 113:711-723
The role of estrogen receptor alpha (ERα) in breast cancer has been studied extensively, and its protein expression is prognostic and a primary determinant of endocrine sensitivity. However, much less is known about the role of ERβ and its relevanc
Autor:
JN Ingle, Muzaffer Cicek, K.D. Peters, Matthew P. Goetz, Sarah B. Grygo, Kevin S. Pitel, Malayannan Subramaniam, Thomas C. Spelsberg, John R. Hawse, Xianglin Wu, Urszula T. Iwaniec, RT Turner, GL Evans
Publikováno v:
Cancer Research. 71:P3-16
Background Commonly used endocrine therapies for breast cancer, such as aromatase inhibitors in postmenopausal women and tamoxifen in premenopausal women, have deleterious effects on bone mineral density. Therefore, the identification of novel cancer