Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas C. Scanlon"'
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e16788 (2011)
Human lysozyme is a key component of the innate immune system, and recombinant forms of the enzyme represent promising leads in the search for therapeutic agents able to treat drug-resistant infections. The wild type protein, however, fails to partic
Externí odkaz:
https://doaj.org/article/76e2b8418ffb4f2db96d0f368d6432f5
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17042 (2011)
Alginate lyase enzymes represent prospective biotherapeutic agents for treating bacterial infections, particularly in the cystic fibrosis airway. To effectively deimmunize one therapeutic candidate while maintaining high level catalytic proficiency,
Externí odkaz:
https://doaj.org/article/70e3c1c343d9462c9be2bdfc4b106346
Publikováno v:
ACS Chemical Biology. 10:1110-1117
The accelerating spread of drug-resistant bacteria is creating demand for novel antibiotics. Bactericidal enzymes, such as human lysozyme (hLYZ), are interesting drug candidates due to their inherent catalytic nature and lack of susceptibility to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f607da5093869e4b97fa99b2d986111a
https://doi.org/10.1021/cb500976y
https://doi.org/10.1021/cb500976y
Publikováno v:
Biotechnology and Bioengineering. 116:475-475
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2c660e29b3807f00d6b66985369f0f
https://doi.org/10.1002/bit.26840
https://doi.org/10.1002/bit.26840
Publikováno v:
Biotechnology and Bioengineering. 111:232-243
We describe an ultra-high-throughput screening platform enabling discovery and/or engineering of natural product antibiotics. The methodology involves creation of hydrogel-in-oil emulsions in which recombinant microorganisms are co-emulsified with ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c002488489dec9aaf571d64d61ec540a
https://doi.org/10.1002/bit.25019
https://doi.org/10.1002/bit.25019
Publikováno v:
Bioengineered Bugs. 1:225-228
Most researchers confidently assume that transformation of recombinant plasmid libraries into microbial hosts followed by outgrowth of isolated colonies results in a “one cell—one mutant gene—one protein variant” paradigm. Indeed, this assump
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21918b8956b1a1abc365a9564d60b38a
https://doi.org/10.4161/bbug.1.3.11724
https://doi.org/10.4161/bbug.1.3.11724
Autor:
Charlotte C. Teneback, Laurie W Leclair, Thomas C. Scanlon, Matthew J. Wargo, Karl E. Griswold, Jenna Bement
The spread of drug-resistant bacterial pathogens is a growing global concern and has prompted an effort to explore potential adjuvant and alternative therapies derived from nature's repertoire of bactericidal proteins and peptides. In humans, the air
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653ca50c0f2051124ee4007102066167
https://europepmc.org/articles/PMC3811238/
https://europepmc.org/articles/PMC3811238/
Autor:
Joshua A. Weiner, John W. Lamppa, Charlotte C. Teneback, Laurie W Leclair, Thomas C. Scanlon, Avinash Gill, Jenna Bement, Karl E. Griswold
Publikováno v:
ACS chemical biology. 5(9)
Lysozymes contain a disproportionately large fraction of cationic residues, and are thereby attracted towards the negatively charged surface of bacterial targets. Importantly, this conserved biophysical property may inhibit lysozyme antibacterial fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924db78e957088566901737b4897124f
https://pubmed.ncbi.nlm.nih.gov/20604527
https://pubmed.ncbi.nlm.nih.gov/20604527
Autor:
Charlotte C. Teneback, Karl E. Griswold, Thomas C. Scanlon, Laurie A. Whittaker, Matthew J. Wargo
Publikováno v:
A52. PNEUMONIA: HOST DEFENSE MECHANISMS TO INFECTIOUS CHALLENGE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adbc81f6c7011c30b438bb717c1ecf90
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1793
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1793
Publikováno v:
BMC Biotechnology
BMC Biotechnology, Vol 9, Iss 1, p 95 (2009)
BMC Biotechnology, Vol 9, Iss 1, p 95 (2009)
Background In addition to providing the molecular machinery for transcription and translation, recombinant microbial expression hosts maintain the critical genotype-phenotype link that is essential for high throughput screening and recovery of protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9083e7b0ac11b7ef4ddfad2afa56f9a
https://doi.org/10.1186/1472-6750-9-95
https://doi.org/10.1186/1472-6750-9-95