Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas C. Irvin"'
Autor:
Meining Wang, Thomas C. Irvin, Christine A. Herdman, Ramsey D. Hanna, Sergio A. Hassan, Yong-Sok Lee, Sophia Kaska, Rachel Saylor Crowley, Thomas E. Prisinzano, Sarah L. Withey, Carol A. Paronis, Jack Bergman, Saadet Inan, Ellen B. Geller, Martin W. Adler, Theresa A. Kopajtic, Jonathan L. Katz, Aaron M. Chadderdon, John R. Traynor, Arthur E. Jacobson, Kenner C. Rice
Publikováno v:
Molecules, Vol 25, Iss 11, p 2640 (2020)
(−)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [35S]GTPγS binding, forskolin-induced cAMP accumulation assay, and MO
Externí odkaz:
https://doaj.org/article/413521e5240a47c49d66570b815acccf
Autor:
Jiranun Jiratrakanvong, Jinjian Shao, Jiaqi Li, Miguel Menendez Alvarez, Xintian Li, Prajwal Das, Grant Nikseresht, Nikhil Miskin, Ran Huo, Jules Nabon, Tristan Leduc, Eric Zhang, Weikang Ma, Gady Agam, Thomas C. Irving
Publikováno v:
Journal of Synchrotron Radiation, Vol 31, Iss 5, Pp 1401-1408 (2024)
MuscleX is an integrated, open-source computer software suite for data reduction of X-ray fiber diffraction patterns from striated muscle and other fibrous systems. It is written in Python and runs on Linux, Microsoft Windows or macOS. Most modules c
Externí odkaz:
https://doaj.org/article/6394f97a58f94baeabb89283c33f5ba7
Autor:
Arthur E. Jacobson, J. Brian Morgan, Thomas C. Irvin, Gary R. Matyas, Zoltan Beck, Kenner C. Rice, Rodell C. Barrientos, Oscar B. Torres, Eugene S. Gutman
Publikováno v:
Rsc Chemical Biology
Active immunization is being explored as a potential therapeutic to combat accidental overdose and to mitigate the abuse potential of opioids. Hapten design is one of the crucial factors that determines the efficacy of a candidate vaccine to substanc
Autor:
Anthony L. Hessel, Michel N. Kuehn, Seong-Won Han, Weikang Ma, Thomas C. Irving, Brent A. Momb, Taejeong Song, Sakthivel Sadayappan, Wolfgang A. Linke, Bradley M. Palmer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract In striated muscle, the sarcomeric protein myosin-binding protein-C (MyBP-C) is bound to the myosin thick filament and is predicted to stabilize myosin heads in a docked position against the thick filament, which limits crossbridge formation
Externí odkaz:
https://doaj.org/article/10a433d29a114c5bb280881b6bad3e35
Autor:
Anthony L. Hessel, Nichlas M. Engels, Michel N. Kuehn, Devin Nissen, Rachel L. Sadler, Weikang Ma, Thomas C. Irving, Wolfgang A. Linke, Samantha P. Harris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Muscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and flexible protein that is tightly bound to the thick filament at it
Externí odkaz:
https://doaj.org/article/3e3b21ca5df3481fb34d9c953325e1ab
Autor:
Sophia Kaska, Christine A. Herdman, Sergio A. Hassan, Thomas E. Prisinzano, Yong-Sok Lee, Sarah L. Withey, Saadet Inan, Martin W. Adler, Rachel Saylor Crowley, Meining Wang, Thomas C. Irvin, Jonathan L. Katz, Arthur E. Jacobson, Jack Bergman, Aaron M. Chadderdon, Theresa A. Kopajtic, Kenner C. Rice, John R. Traynor, Ellen B. Geller, Carol A. Paronis, Ramsey D. Hanna
Publikováno v:
Molecules
Volume 25
Issue 11
Molecules, Vol 25, Iss 2640, p 2640 (2020)
Volume 25
Issue 11
Molecules, Vol 25, Iss 2640, p 2640 (2020)
(&minus
)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [35S]GTP&gamma
S binding, forskolin-induced cAMP accumul
)-N-Phenethyl analogs of optically pure N-norhydromorphone were synthesized and pharmacologically evaluated in several in vitro assays (opioid receptor binding, stimulation of [35S]GTP&gamma
S binding, forskolin-induced cAMP accumul
Autor:
Kevin Ronald Condroski, Kolakowski Gabrielle R, Thomas C. Irvin, Nisha A. Patel, Manoj Kumar, Joshua Ballard, Erin D. Anderson, Andrews Steven W, Eliana B. Gomez, Barbara J. Brandhuber, Faith D. Watson
Publikováno v:
Cancer Research. 81:1464-1464
In May 2020, selpercatinib became the first FDA-approved selective RET inhibitor, indicated for patients (pts) with RET fusion-positive NSCLC and thyroid cancer as well as RET-mutant medullary thyroid cancer. Despite the durable activity of selpercat
Publikováno v:
Tetrahedron Letters. 56:3326-3329
Alcohols undergo dehydration in a one-pot procedure when the alkoxide, formed by treating the starting alcohol dissolved in toluene with NaH, reacts with phenyl isothiocyanate and the resulting sodium carbonimidothioate salt is heated overnight at 20
Publikováno v:
ChemInform. 46
Alcohols undergo dehydration in a one-pot procedure when the alkoxide, formed by treating the starting alcohol dissolved in toluene with NaH, reacts with phenyl isothiocyanate and the resulting sodium carbonimidothioate salt is heated overnight at 20
Autor:
Michelle Rodriguez Garcia, Jeffrey Schmeckpeper, Maicon Landim-Vieira, Isabella Leite Coscarella, Xuan Fang, Weikang Ma, Payton A. Spran, Shengyao Yuan, Lin Qi, Aida Rahimi Kahmini, M. Benjamin Shoemaker, James B. Atkinson, Peter M. Kekenes-Huskey, Thomas C. Irving, Prescott Bryant Chase, Björn C. Knollmann, Jose Renato Pinto
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14572 (2023)
The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significance (p.A868T) on cardiac muscle structure and functi
Externí odkaz:
https://doaj.org/article/5f43ec315b34474db0d9718fcffd7e19