Výsledky vyhledávání - "Thomas C. Hutsell"

Local Delivery of an Ultra-short-acting Nitric Oxide- releasing Compound, DMHD/NO, Is Highly Effective in Inhibiting Acute Platelet-Thrombus Formation on Injured Arterial Strips

Autor: Tasneem Z. Naqvi, Sasha Thomas, Sanjay Kaul, Juan J. Badimon, Prediman K. Shah, Mia D. Molloy, Michael C. Fishbein, Bojan Cercek, Thomas C. Hutsell

Publikováno v: Journal of Cardiovascular Pharmacology and Therapeutics. 2:181-193

Background: Nitric oxide (NO) plays an important role in modulating platelet-vessel wall interaction following vascular injury. We examined the effects of local infusion of an ultra- short-acting NO-releasing compound: NO adduct of N, N'-dimethylhexa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98331e849e61ed0d062b93e7b7e254db
https://doi.org/10.1177/107424849700200305

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Inhibition of Acute Stent Thrombosis Under High-Shear Flow Conditions by a Nitric Oxide Donor, DMHD/NO

Autor: Frank Litvack, Neal L. Eigler, James S. Forrester, Masato Nakamura, Thomas C. Hutsell, Sanjay Kaul, Prediman K. Shah, Raj Makkar

Publikováno v: Circulation. 94:2228-2234

Background Coronary stenting is limited by subacute thrombosis, especially in smaller-diameter vessels, in which shear rates are high. The objective of the present study was to determine whether local delivery of a new type of NO donor, the NO adduct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3c115993d6e5a24c83ddc0e6ac2ee8
https://doi.org/10.1161/01.cir.94.9.2228

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Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension

Autor: Stephen L. Archer, Vaclav Hampl, Martin Tristani-Firouzi, Thomas C. Hutsell

Publikováno v: Cardiovascular Research. 31:55-62

Objective : Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, but its use has been restricted almost exclusively to the intensive care setting due to the complexity of its delivery. NO/nucleophile adducts, such as diethylenetriamine/NO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb746de24d8c0359ae7805c5a9ae81a2
https://doi.org/10.1016/s0008-6363(95)00172-7

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Nitric Oxide (NO) Donor Molecules

Autor: Larry K. Keefer, Daniel L. Mooradian, Thomas C. Hutsell

Publikováno v: Journal of Cardiovascular Pharmacology. 25:674-678

Nitric oxide (NO) inhibits vascular smooth muscle cell (SMC) growth in vitro. To determine the effects of release rate and exposure time on SMC growth inhibition by NO, we compared the activities of five NO donors that generate NO with half-lives of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::163e2b5b0bdcaa8f077958e9327ba461
https://doi.org/10.1097/00005344-199504000-00023

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Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery

Autor: Changyi Chen, Keith M. Davies, Larry K. Keefer, David N. Ku, Joseph E. Saavedra, Alan B. Lumsden, Stephen R. Hanson, John D. Hughes, Thomas C. Hutsell

Publikováno v: The Journal of surgical research. 67(1)

To evaluate the direct effect of nitric oxide (NO) on vascular smooth muscle cell (SMC) proliferation in vivo, we used an expanded polytetrafluoroethylene (ePTFE)-based local infusion device to deliver an NO donor, proline/NO (PROLI/NO), to the lumin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193ccc965768c5dead78fcb9f5c5b1e9
https://pubmed.ncbi.nlm.nih.gov/9070177

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Nitric oxide-releasing polymers containing the [N(O)NO]- group

Autor: Joseph A. Hrabie, Daniel L. Mooradian, Thomas C. Hutsell, Stephen R. Hanson, Pulfer Sharon, Debashish Chakravarthy, Daniel J. Smith, Michael L. Citro, Keith M. Davies, Maia L. Simmons, Larry K. Keefer, Joseph E. Saavedra

Publikováno v: Journal of medicinal chemistry. 39(5)

Ions of structure X[N(O)NO]- display broad-spectrum pharmacological activity that correlates with the rate and extent of their spontaneous, first-order decomposition to nitric oxide when dissolved. We report incorporation of this functional group int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b945b2c113a695318fd3d267056ac238
https://pubmed.ncbi.nlm.nih.gov/8676352

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Nitric Oxide Donors: A Continuing Opportunity in Drug Design

Autor: Larry K. Keefer, Daniel L. Mooradian, Daniel J. Smith, Thomas C. Hutsell, Stephen R. Hanson

Publisher Summary This chapter illustrates the advantageous, much unique, chemical, and pharmacological properties of nitric oxide (NO) donor compound class by showing how the accumulating knowledge are used in this area in attempting to design solut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f4a448eb86ed5cad246f8276fe60f90
https://doi.org/10.1016/s1054-3589(08)61099-6

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797-3 Restoration of Thromboresistance in Injured Aortic Segments by a Novel Nitric Oxide Donor

Autor: Michael C. Fishbein, Mia D. Molloy, Tasneem Z. Naqvi, Prediman K. Shah, Sanjay Kaul, Arun M. Thomas, Thomas C. Hutsell, Bojan Cercek, Lina Badimon

Publikováno v: Journal of the American College of Cardiology. 25:382A

Endothelium-derived nitric oxide (NO) is one of the principal mediators of thromboresistance in intact blood vessels. To determine whether repletion of NO would restore thromboresistance in injured arterial segments, we investigated the effect of a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25c2166efbd66184b61c0512b13a5a4
https://doi.org/10.1016/0735-1097(95)93043-c

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