Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Thomas C. Foster"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
There are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli. The response includes a state of irreve
Externí odkaz:
https://doaj.org/article/b105104a5d394f09ab5acc7231aa9874
Autor:
Jessica A. Peterson, Larissa J. Strath, Chavier Laffitte Nodarse, Asha Rani, Zhiguang Huo, Lingsong Meng, Sean Yoder, James H. Cole, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2178-2187 (2022)
Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been observed in those with chronic pain. However, it is unknown whether these biological markers of a
Externí odkaz:
https://doaj.org/article/aae0aa138060444e9da2fe3e33601a46
Autor:
Jessica A. Peterson, Joshua A. Crow, Alisa J. Johnson, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical funct
Externí odkaz:
https://doaj.org/article/d3818217c6ef44e7834a626ca2d40dc7
Autor:
Soamy Montesino-Goicolea, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Neurobiology of Pain, Vol 12, Iss , Pp 100107- (2022)
Our study aimed to identify differentially methylated regions (i.e., genomic region where multiple adjacent CpG sites show differential methylation) and their enriched genomic pathways associated with knee osteoarthritis pain (KOA). We recruited cogn
Externí odkaz:
https://doaj.org/article/38703b23431746f489939e172fec646e
Autor:
Larissa J. Strath, Lingsong Meng, Asha Rani, Zhiguang Huo, Thomas C. Foster, Roger B. Fillingim, Yenisel Cruz-Almeida
Publikováno v:
Lifestyle Genomics, Pp 1-1 (2023)
Context: Recent evidence suggests that Vitamin D may interact with the epigenome and play a role in the pain experience. In order for proper functioning to occur, there must be an adequate level of Vitamin D present, made possible by enzymatic reacti
Externí odkaz:
https://doaj.org/article/fc494b0e3bfd4481979ce50fcb82d0f5
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Aging is the most prominent risk factor for cognitive decline, yet behavioral symptomology and underlying neurobiology can vary between individuals. Certain individuals exhibit significant age-related cognitive impairments, while others maintain inta
Externí odkaz:
https://doaj.org/article/c7eca479fd6a49009691e455c0587e92
Autor:
Hyo-Jin Park, Mi-Jung Kim, Christina Rothenberger, Ashok Kumar, Edith M. Sampson, Dalian Ding, Chul Han, Karessa White, Kevin Boyd, Senthilvelan Manohar, Yong-Hwan Kim, Maria S. Ticsa, Aaron S. Gomez, Isabela Caicedo, Upal Bose, Paul J. Linser, Takuya Miyakawa, Masaru Tanokura, Thomas C. Foster, Richard Salvi, Shinichi Someya
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
A common complication of cisplatin-based chemotherapy is hearing loss. Here, Park et al. show that glutathione transferase α4 (GSTA4) contributes to reducing cisplatin toxicity in the inner ear of female mice by removing 4-hydroxynonenal (4-HNE).
Externí odkaz:
https://doaj.org/article/a4b9d8b940ff4c42bbb2c14bdd319a1a
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to th
Externí odkaz:
https://doaj.org/article/dd9c3740a3e94e0db14a852d811ea1d4
Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies
Autor:
Joseph A. McQuail, Amy R. Dunn, Yaakov Stern, Carol A. Barnes, Gerd Kempermann, Peter R. Rapp, Catherine C. Kaczorowski, Thomas C. Foster
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2021)
The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forth
Externí odkaz:
https://doaj.org/article/36f44c766a3f4b158589d4ac6f731c19
Autor:
Ashok Kumar, Thomas C. Foster
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
In the hippocampus, estrogen regulates gene transcription linked to neuronal growth, neuroprotection, and the maintenance of memory function (1–3). The mechanism is likely to involve genomic regulation through classic estrogen receptor (ER) signali
Externí odkaz:
https://doaj.org/article/152e07f32b3b49c08b588cb8de4d5f5a