Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Thomas C. Diehl"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Current hypotheses and theories regarding the pathogenesis of Alzheimer’s disease (AD) heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well-validated metrics for systemic IR, the absence of biomarkers for brain-spe
Externí odkaz:
https://doaj.org/article/ed1cffeaf4de4ba9b4365aea2ce1da1c
Publikováno v:
Translational Research. 183:26-40
The links between systemic insulin resistance (IR), brain-specific IR, and Alzheimer's disease (AD) have been an extremely productive area of current research. This review will cover the fundamentals and pathways leading to IR, its connection to AD v
Autor:
Joyce Tran, Chiung-Wei Huang, Sahil Chawla, Sean T. Berkowitz, Erez Eitan, Constantine G. Lyketsos, Maja Mustapić, Michael P. Lazaropoulos, Yang An, Ryan Spangler, Esther S. Oh, Luigi Ferrucci, Dimitrios Kapogiannis, Seema Gulyani, Susan M. Resnick, Michelle Shardell, Thomas C. Diehl, Edward J. Goetzl
Publikováno v:
JAMA Neurol
Importance Blood biomarkers able to diagnose Alzheimer disease (AD) at the preclinical stage would enable trial enrollment when the disease is potentially reversible. Plasma neuronal-enriched extracellular vesicles (nEVs) of patients with AD were rep
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 9 (2017)
Frontiers in Aging Neuroscience, Vol 9 (2017)
Current hypotheses and theories regarding the pathogenesis of Alzheimer’s disease (AD) heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well-validated metrics for systemic IR, the absence of biomarkers for brain-spe