Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Thomas C. Chen"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3058 (2024)
Our previous research studies have demonstrated the role of microRNA133b (miR133b) in healing the contused spinal cord when administered either intranasally or intravenously 24 h following an injury. While our data showed beneficial effects of exogen
Externí odkaz:
https://doaj.org/article/a9e81c16774e4bbbb1b3bc577c1b6319
Autor:
Hannah Hartman-Houstman, Steve Swenson, Radu O. Minea, Uttam K. Sinha, Ming-Fu Chiang, Thomas C. Chen, Axel H. Schönthal
Publikováno v:
Cancers, Vol 16, Iss 5, p 936 (2024)
The Epstein–Barr virus (EBV) is accepted as a primary risk factor for certain nasopharyngeal carcinoma (NPC) subtypes, where the virus persists in a latent stage which is thought to contribute to tumorigenesis. Current treatments are sub-optimal, a
Externí odkaz:
https://doaj.org/article/bac9640009a4493a919736ad5a7ec0f4
Autor:
Daniela A. Bota, Thomas H. Taylor, Naomi Lomeli, Xiao-Tang Kong, Beverly D. Fu, Axel H. Schönthal, Samuel Singer, Deborah T. Blumenthal, Frank M. Senecal, Helena Linardou, Evangelos Rokas, Dimitris G. Antoniou, Virgil E. J. C. Schijns, Thomas C. Chen, Joseph Elliot, Apostolos Stathopoulos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundGlioblastoma (GBM) is the most common primary, malignant brain tumor in adults and has a poor prognosis. The median progression-free survival (mPFS) of newly diagnosed GBM is approximately 6 months. The recurrence rate approaches 100%, and
Externí odkaz:
https://doaj.org/article/797a63071f0044c39c85c3954e4ac46c
Publikováno v:
Cells, Vol 12, Iss 6, p 931 (2023)
Despite important advances in the pre-clinical animal studies investigating the neuroinhibitory microenvironment at the injury site, traumatic injury to the spinal cord remains a major problem with no concrete response. Here, we examined whether (1)
Externí odkaz:
https://doaj.org/article/498d3104b85e4a5ea31dc88c2c5eebaf
Publikováno v:
Cancers, Vol 14, Iss 24, p 6065 (2022)
Many patients with acute myeloid leukemia (AML) are still dying from this disease. In the past, the alkylating agent temozolomide (TMZ) has been investigated for AML and found to be partially effective; however, the presence of O6-methylguanine DNA m
Externí odkaz:
https://doaj.org/article/1f832bb52a4940cd8a16fc9210928125
Autor:
Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carcinoma (NPC), etc.. In
Externí odkaz:
https://doaj.org/article/3807ad53c338401a89bd64dfd85db3b2
Autor:
Minghui Chang, Xingguo Song, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-16 (2018)
Abstract Background Temozolomide-perillyl alcohol conjugate (TMZ-POH), a novel Temozolomide (TMZ) analog developed based on the conjugation of TMZ and perillyl alcohol (POH), displayed strong anticancer potency in multiple cancer types. In this study
Externí odkaz:
https://doaj.org/article/ef7b212ac6da47e1959b84abf71fd072
Autor:
Catalina Silva-Hirschberg, Hannah Hartman, Samantha Stack, Steve Swenson, Radu O. Minea, Michael A. Davitz, Thomas C. Chen, Axel H. Schönthal
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 11 (2019)
Background: Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of primary cutaneous lymphomas and represent complex diseases regarding their physiopathology and management. Depending on the stage of the disease, different treatment regimen
Externí odkaz:
https://doaj.org/article/6f8923ff18ae4271b600c5369da99084
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2167 (2021)
Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is present in the essential oils of various plants. It has diverse applications and can be found in household items, including foods, cosmetics, and cleaning suppl
Externí odkaz:
https://doaj.org/article/f038b9c6e61946db80307dcc84c7b2a0
Autor:
Axel H. Schönthal, Steve Swenson, Radu O. Minea, Hye Na Kim, Heeyeon Cho, Nazleen Mohseni, Yong-Mi Kim, Thomas C. Chen
Publikováno v:
Cancers, Vol 13, Iss 14, p 3385 (2021)
Despite progress in the treatment of acute myeloid leukemia (AML), the clinical outcome remains suboptimal and many patients are still dying from this disease. First-line treatment consists of chemotherapy, which typically includes cytarabine (AraC),
Externí odkaz:
https://doaj.org/article/7d2d96345e0843c59db426a2c726b0d5