Zobrazeno 1 - 10
of 652
pro vyhledávání: '"Thomas C. Bruice"'
Publikováno v:
Chemical Reviews. 112:1284-1309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46bb8e6bd26e94cc77653749a8837f8
https://doi.org/10.1021/cr1004265
https://doi.org/10.1021/cr1004265
Autor:
Thomas C. Bruice, Myun-Ji Park
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3982-3986
The immortality of cancer cells is due to the relatively high concentration of telomerase enzyme that maintains the telomere sequence during cell division. Human telomeric DNA consists of repeats of the sequence d(5'-TTAGGG-3'). Deoxyribonucleic guan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a823816b2db6f2f66329d83794049b8d
https://doi.org/10.1016/j.bmcl.2010.04.089
https://doi.org/10.1016/j.bmcl.2010.04.089
Autor:
Jia Luo, Thomas C. Bruice
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 27:245-257
Normal mode analysis, using the elastic network model, has been employed to envision the low frequency normal mode motion trends in the structures of five intermediates and a transition state in the kinetic pathway of E. coli dihydrofolate reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b169c4cb49dca28f9d24b658d11bb936
https://doi.org/10.1080/07391102.2009.10507313
https://doi.org/10.1080/07391102.2009.10507313
Autor:
Xiao-Dong Zhang, Thomas C. Bruice
Publikováno v:
Proceedings of the National Academy of Sciences. 105:5728-5732
Molecular dynamics and hybrid quantum mechanics/molecular mechanics have been used to investigate the mechanisms of + AdoMet methylation of protein-Lys-NH 2 catalyzed by the lysine methyltransferase enzymes: histone lysine monomethyltransferase SET7/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abbafa4684eec9d678a899c4e783d64
https://doi.org/10.1073/pnas.0801788105
https://doi.org/10.1073/pnas.0801788105
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2377-2384
Oligodeoxynucleic acid (21-mer) containing both negatively charged phosphate and positively charged ribonucleic guanidine linkages (RNG/DNA chimera) have been synthesized. DNA binding characteristics and nuclease resistance of RNG/DNA chimeras have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054c748e5ba28dac5e8232445614b2de
https://doi.org/10.1016/j.bmcl.2008.02.063
https://doi.org/10.1016/j.bmcl.2008.02.063
Autor:
Xiao-Dong Zhang, Thomas C. Bruice
Publikováno v:
Biochemistry. 47:2743-2748
The catalysis by SET7/9 histone lysine methyltransferase of AdoMet N-methylation of the transcriptional factor p53-Lys4-NH 2 has been investigated with particular attention paid to the means of product specificity. After formation of the SET7/9.p53-L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2486f0efd791513bd4c98a62082eb5cf
https://doi.org/10.1021/bi702370p
https://doi.org/10.1021/bi702370p
Autor:
Thomas C. Bruice, Xiao-Dong Zhang
Publikováno v:
Biochemistry. 46:5505-5514
Molecular dynamics (MD) simulations and hybrid quantum mechanics/molecular mechanics (QM/MM) calculations have been carried out in an investigation of Rubisco large subunit methyltransferase (LSMT). It was found that the appearance of a water channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66940b83faa272f645f6e0ef41f1c769
https://doi.org/10.1021/bi700119p
https://doi.org/10.1021/bi700119p
Publikováno v:
Biophysical Chemistry. 126:132-139
Molecular dynamics has been employed to analyze the counterion and water atmospheres around the deoxynucleic guanidine (DNG) duplex G12·C12. These features are compared to those of DNA G12·C12. The chloride counterions of cationic DNG demonstrate f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29bc0f731464f6842acfcb3136347c6
https://doi.org/10.1016/j.bpc.2006.02.006
https://doi.org/10.1016/j.bpc.2006.02.006
Publikováno v:
Proceedings of the National Academy of Sciences. 104:745-749
At neutral pH, oxidation of CH 3 OH → CH 2 O by an o -quinone requires general-base catalysis and the reaction is endothermic. The active-site –CO 2 − groups of Glu-171 and Asp-297 (Glu-171–CO 2 − and Asp-297–CO 2 − ) have been consider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762242b9ad1bb2b25a5c58d3a4acfcfe
https://doi.org/10.1073/pnas.0610126104
https://doi.org/10.1073/pnas.0610126104
Autor:
Thomas C. Bruice, Xiaohua Zhang
Publikováno v:
Biochemistry. 46:837-843
The catalytic chemistry of the thermophilic Bacillus stearothermophilus alcohol dehydrogenase (HtADH) closely resembles that of mesophilic horse liver alcohol dehydrogenase (HLADH). Molecular dynamics (MD) simulations of the htADH x NAD+ x EtO- compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34504a4933c0a77c3486dd5b4738149c
https://doi.org/10.1021/bi062110+
https://doi.org/10.1021/bi062110+