Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Thomas C. Becker"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 1025-1038 (2024)
Background & Aims: This review was developed to provide a thorough and effective update on models relevant to esophageal metaplasia, dysplasia, and carcinogenesis, focusing on the advantages and limitations of different models of Barrett’s esophagu
Externí odkaz:
https://doaj.org/article/3619ea67db15495495631df88443fc9a
Autor:
Huan Wang, Aaron Bender, Peng Wang, Esra Karakose, William B. Inabnet, Steven K. Libutti, Andrew Arnold, Luca Lambertini, Micheal Stang, Herbert Chen, Yumi Kasai, Milind Mahajan, Yayoi Kinoshita, Gustavo Fernandez-Ranvier, Thomas C. Becker, Karen K. Takane, Laura A. Walker, Shira Saul, Rong Chen, Donald K. Scott, Jorge Ferrer, Yevgeniy Antipin, Michael Donovan, Andrew V. Uzilov, Boris Reva, Eric E. Schadt, Bojan Losic, Carmen Argmann, Andrew F. Stewart
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Diabetes results in part from a deficiency of functional pancreatic beta cells. Here, the authors study the genomic and epigenetic landscapes of human insulinomas to gain insight into possible pathways for therapeutic beta cell regeneration, highligh
Externí odkaz:
https://doaj.org/article/80c3e45c47014686a61554de1f26c1c1
Autor:
James B Robertson, Amy Stieler Stewart, Jennifer Luff, Cecilia Schaaf, Thomas C. Becker, Liara M. Gonzalez, Sara R Tufts, John M. Freund
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G588-G602
This paper supports that rISCs are resistant to ischemic injury and likely an important source of cellular renewal following near-complete epithelial loss. Furthermore, we have evidence that HOPX controls ISC activity state and may be a critical sign
Autor:
Amy Stieler, Stewart, Cecilia Renee, Schaaf, Jennifer A, Luff, John M, Freund, Thomas C, Becker, Sara R, Tufts, James B, Robertson, Liara M, Gonzalez
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Intestinal ischemia is a life-threatening emergency with mortality rates of 50%–80% due to epithelial cell death and resultant barrier loss. Loss of the epithelial barrier occurs in conditions including intestinal volvulus and neonatal necrotizing
Autor:
Katherine S. Garman, Richard von Furstenberg, Ryan Fecteau, Thomas C. Becker, Biswa P. D. Purkayastha, Gary W. Falk, Dawn Dawson, Joseph E. Willis, Shannon J. McCall, Andrew E. Blum, Kishore Guda, Amitabh Chak
INTRODUCTION: Aggregation of Barretts esophagus (BE) and esophageal adenocarcinoma (EAC) in families has been termed familial Barretts esophagus (FBE). Analysis of single, large FBE families can enable the identification of genetic susceptibility to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cba647e07569c9cfd70e4991b1e6fbda
https://doi.org/10.1101/2021.05.15.444305
https://doi.org/10.1101/2021.05.15.444305
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:678-687
Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HK
Publikováno v:
Diabetes
Syntaxin 4 (Stx4) enrichment in human and mouse islet grafts improves the success of transplants in reversing streptozotocin (STZ)-induced diabetes in mice, although the underlying molecular mechanisms remain elusive. Toward a further understanding o
Autor:
Jose Cordoba-Chacon, Stephen Harrison, Navdeep S. Chandel, Thomas C. Becker, Nicholas Giancola, Haaris Pervaiz, Alexander R. Terry, Wasim Khan, Brian T. Layden, Kai Xu, Carolina M. Pusec, Adam De Jesus, Emily Daviau Smith, Anton E. Ludvik, Hossein Ardehali, Nissim Hay, Xianzhong Ding
Glucokinase (GCK) is the principal hexokinase (HK) in the liver, operating as a glucose sensor to regulate glucose metabolism and lipid homeostasis. Recently, we proposed HK domain-containing 1 (HKDC1) to be a fifth HK with expression in the liver. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deb0dfa164d393edb4848ea0cd0172d
https://europepmc.org/articles/PMC6334269/
https://europepmc.org/articles/PMC6334269/
Autor:
Mette V. Jensen, Christopher B. Newgard, Sarah M. Gray, Danhong Lu, Guo-Fang Zhang, Jonathan E. Campbell, You Wang, Thomas C. Becker, Kimberley El
Publikováno v:
Cell Metab
Summary Metabolic fuels regulate insulin secretion by generating second messengers that drive insulin granule exocytosis, but the biochemical pathways involved are incompletely understood. Here we demonstrate that stimulation of rat insulinoma cells
Autor:
Christopher J. Rhodes, Louis H. Philipson, Lynn W. Enquist, Inderroop Singh, Jonathan N. Flak, Thomas C. Becker, Natalia A. Tamarina, Martin G. Myers, Christa M. Patterson, Wilfredo Rosario, Arnaud Wautlet, Almas Ali
Publikováno v:
Diabetes. 65:2711-2723
The brain influences glucose homeostasis, partly by supplemental control over insulin and glucagon secretion. Without this central regulation, diabetes and its complications can ensue. Yet, the neuronal network linking to pancreatic islets has never