Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Thomas C Terwilliger"'
Autor:
Heung-Bok Kim, John-Paul Bacik, Ruilian Wu, Ramesh K Jha, Michaeline Hebron, Catherine Triandafillou, Joseph E McCown, Nam-In Baek, Jeong Han Kim, Young Jae Kim, Celia W Goulding, Charlie E M Strauss, Jurgen G Schmidt, Gauri S Shetye, Sungweon Ryoo, Eun-Kyeong Jo, Young Ho Jeon, Li-Wei Hung, Thomas C Terwilliger, Chang-Yub Kim
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277670 (2022)
The ability of Mycobacterium tuberculosis (Mtb) to persist in its host may enable an evolutionary advantage for drug resistant variants to emerge. A potential strategy to prevent persistence and gain drug efficacy is to directly target the activity o
Externí odkaz:
https://doaj.org/article/e919c5aa126347f3a5b5b38c338f2953
Autor:
Daniil M Prigozhin, Inna V Krieger, John P Huizar, Daniela Mavrici, Geoffrey S Waldo, Li-Wei Hung, James C Sacchettini, Thomas C Terwilliger, Tom Alber
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116249 (2014)
Beta-lactam antibiotics target penicillin-binding proteins including several enzyme classes essential for bacterial cell-wall homeostasis. To better understand the functional and inhibitor-binding specificities of penicillin-binding proteins from the
Externí odkaz:
https://doaj.org/article/1bbc03da4e664bf7ae5ff99510a4bd03
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2387 (2008)
The GFP folding reporter assay uses a C-terminal GFP fusion to report on the folding success of upstream fused polypeptides. The GFP folding assay is widely-used for screening protein variants with improved folding and solubility, but truncation arti
Externí odkaz:
https://doaj.org/article/9606a9d9987541b88c933c02ae5a326e
Autor:
Reliza J. McGinnis, Chad A. Brambley, Brandon Stamey, William C. Green, Kimberly N. Gragg, Erin R. Cafferty, Thomas C. Terwilliger, Michal Hammel, Thomas J. Hollis, Justin M. Miller, Maria D. Gainey, Jamie R. Wallen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
Externí odkaz:
https://doaj.org/article/c5e01eafbf234add839bb6caacf2cd40
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Split green fluorescent protein (GFP) has been used in a panoply of cellular biology applications to study protein translocation, monitor protein solubility and aggregation, detect protein–protein interactions, enhance protein crystallizat
Externí odkaz:
https://doaj.org/article/79c928c86b214c6d82d1df592da8ced9
Publikováno v:
IUCrJ, Vol 4, Iss 1, Pp 87-99 (2017)
A topical review is presented of the rapidly developing interest in and storage options for the preservation and reuse of raw data within the scientific domain of the IUCr and its Commissions, each of which operates within a great diversity of instru
Externí odkaz:
https://doaj.org/article/0015098d45854070a198da9f23a19720
Fast, reliable docking of models into cryo-EM maps requires understanding of the errors in the maps and the models. Likelihood-based approaches to errors have proven to be powerful and adaptable in experimental structural biology, finding application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824b4cd981b9c7ee9c0bbe4c515fe129
Autor:
Thomas C. Terwilliger, Pavel V. Afonine, Dorothee Liebschner, Tristan I. Croll, Airlie J. McCoy, Robert D. Oeffner, Christopher J. Williams, Billy K. Poon, Jane S. Richardson, Randy J. Read, Paul D. Adams
Publikováno v:
Acta crystallographica. Section D, Structural biology, vol 79, iss Pt 3
Funder: Phenix Industrial Consortium
Experimental structure determination can be accelerated with artificial intelligence (AI)-based structure-prediction methods such as AlphaFold. Here, an automatic procedure requiring only sequence information
Experimental structure determination can be accelerated with artificial intelligence (AI)-based structure-prediction methods such as AlphaFold. Here, an automatic procedure requiring only sequence information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b955055d92d6f63de0b4875ac8df1a
https://www.repository.cam.ac.uk/handle/1810/348418
https://www.repository.cam.ac.uk/handle/1810/348418
Autor:
Thomas C. Terwilliger, Dorothee Liebschner, Tristan I. Croll, Christopher J. Williams, Airlie J. McCoy, Billy K. Poon, Pavel V. Afonine, Robert D. Oeffner, Jane S. Richardson, Randy J. Read, Paul D. Adams
AI-based methods such as AlphaFold have revolutionized structural biology, often making it possible to predict protein structures with high accuracy. The accuracies of these predictions vary, however, and they do not include ligands, covalent modific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84a7739ffd488fa251320886bfaa610b
https://doi.org/10.1101/2022.11.21.517405
https://doi.org/10.1101/2022.11.21.517405
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Acta crystallographica. Section D, Structural biology, vol 76, iss Pt 10
Acta crystallographica. Section D, Structural biology, vol 76, iss Pt 10
The prerequisites for density modification of maps from electron cryomicroscopy are examined and a procedure for incorporating model-based information is presented.
Density modification uses expectations about features of a map such as a flat so
Density modification uses expectations about features of a map such as a flat so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b90792cc2d49645121df43aaf13b0
http://europepmc.org/articles/PMC7543659
http://europepmc.org/articles/PMC7543659