Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Thomas C Mitchell"'
Publikováno v:
Innate Immunity, Vol 25 (2019)
LPS delays neutrophil apoptosis by a process generally assumed to involve cell-intrinsic TLR4 signaling. However, neutrophil survival responses to LPS have been reported to be monocyte-dependent, which would indicate more complexity than is currently
Externí odkaz:
https://doaj.org/article/37ab62359240437aaeedac625e827880
Autor:
Carolyn R Casella, Thomas C Mitchell
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62622 (2013)
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differentiation primary response protein) branch of the bifurcated TLR4 (Toll-like receptor 4) signaling pathway, in contrast to diphosphoryl lipid A (sDLA),
Externí odkaz:
https://doaj.org/article/aa3f9e54a14d4fa49a17624d4cdab37a
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56855 (2013)
Toll like receptor 4 (TLR4) is an important pattern recognition receptor with the ability to drive potent innate immune responses and also to modulate adaptive immune responses needed for long term protection. Activation of TLR4 by its ligands is med
Externí odkaz:
https://doaj.org/article/b55007ab3cd348daa46501a66805f4ab
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
The vertebrate immune system exists in equilibrium with the microbial world. The innate immune system recognizes pathogen-associated molecular patterns via a family of Toll-like receptors that activate cells upon detection of potential pathogens. Bec
Externí odkaz:
https://doaj.org/article/a6720bd92499469f9c7af73f52e6b010
Autor:
Bodduluri Haribabu, Venkatakrishna R. Jala, Alberto Mantovani, Massimo Locati, Sergio Lira, Thomas C. Mitchell, Paula M. Chilton, Shuchismita R. Satpathy, Elangovan Krishnan, Paramahamsa Maturu, Steven Mathis, Sobha R. Bodduluri
The presence of mast cells in some human colorectal cancers is a positive prognostic factor, but the basis for this association is incompletely understood. Here, we found that mice with a heterozygous mutation in the adenomatous polyposis coli gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba8185feaca01381d5ef228fbfe2ac1
https://doi.org/10.1158/2326-6066.c.6549286
https://doi.org/10.1158/2326-6066.c.6549286
Autor:
Bodduluri Haribabu, Venkatakrishna R. Jala, Alberto Mantovani, Massimo Locati, Sergio Lira, Thomas C. Mitchell, Paula M. Chilton, Shuchismita R. Satpathy, Elangovan Krishnan, Paramahamsa Maturu, Steven Mathis, Sobha R. Bodduluri
S1: Unaltered tumor burden in colons of ACKR2-/-ApcMin/+ mice. S2: Delayed onset of tumor development in the small intestine of ACKR2-/-ApcMin/+ mice. S3. Decreased inflammatory markers in the distal intestine tumors of ACKR2-/-ApcMin/+ mice. S4. Ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2f416398d1718a7887023d3ba3a209
https://doi.org/10.1158/2326-6066.22540117
https://doi.org/10.1158/2326-6066.22540117
Autor:
V. Douglas Landers, Daniel W. Wilkey, Michael L. Merchant, Thomas C. Mitchell, Kevin J. Sokoloski
Publikováno v:
Viruses, Vol 13, Iss 3, p 377 (2021)
Alphaviruses are arthropod-borne RNA viruses which can cause either mild to severe febrile arthritis which may persist for months, or encephalitis which can lead to death or lifelong cognitive impairments. The non-assembly molecular role(s), function
Externí odkaz:
https://doaj.org/article/2b88581758b04bfaabe008da15692862
Autor:
Cassandra R. Woolley, Nicholas C. Brinkman, Elizabeth D. Cash, Swapna K. Chandran, Thomas C. Mitchell
Publikováno v:
ImmunoHorizons. 6:47-63
The Fc receptor for IgM, FcMR, is unusual in that it is preferentially expressed by cells of the adaptive immune system. It is, moreover, the only constitutively expressed Fc receptor on human T cells. Efforts to decipher the normal functions of FcMR
Autor:
Easton E. Ford, David Tieri, Oscar Rodriguez, Nancy Francoeur, Juan Soto, Justin Kos, Ayelet Peres, William Gibson, Catherine A. Silver, Gintaras Deikus, Elizabeth Hudson, Cassandra R. Woolley, Noam Beckmann, Alexander Charney, Thomas C. Mitchell, Gur Yaari, Robert P. Sebra, Corey T. Watson, Melissa L. Smith
Current Adaptive Immune Receptor Repertoire Sequencing (AIRR-seq) strategies resolve expressed antibody (Ab) transcripts with limited resolution of the constant region. Here we present a novel near full-length AIRR-seq (FLAIRR-Seq) method that utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a167cee0de9aad2df121ba79d2943929
https://doi.org/10.1101/2022.09.24.509352
https://doi.org/10.1101/2022.09.24.509352
Autor:
Cassandra R Woolley, Julia H Chariker, Eric C Rouchka, Easton E Ford, Elizabeth A Hudson, Sabine J Waigel, Melissa L Smith, Thomas C Mitchell
Publikováno v:
G3 (Bethesda, Md.). 12(11)
Long-read sequencing technologies such as isoform sequencing can generate highly accurate sequences of full-length mRNA transcript isoforms. Such long-read transcriptomics may be especially useful in investigations of lymphocyte functional plasticity