Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Thomas C Frost"'
Autor:
Jason Nomburg, Wei Zou, Thomas C Frost, Chandreyee Datta, Shobha Vasudevan, Gabriel J Starrett, Michael J Imperiale, Matthew Meyerson, James A DeCaprio
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010401 (2022)
Polyomaviruses (PyV) are ubiquitous pathogens that can cause devastating human diseases. Due to the small size of their genomes, PyV utilize complex patterns of RNA splicing to maximize their coding capacity. Despite the importance of PyV to human di
Externí odkaz:
https://doaj.org/article/617256a3a1db4dce84c7251edeb7863b
Autor:
Thomas C. Frost, Ashley K. Gartin, Mofei Liu, Jingwei Cheng, Harita Dharaneeswaran, Derin B. Keskin, Catherine J. Wu, Anita Giobbie-Hurder, Manisha Thakuria, James A. DeCaprio
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Background Merkel cell carcinoma (MCC) is an aggressive neuroendocrine (NE) skin cancer caused by severe UV-induced mutations or expression of Merkel cell polyomavirus (MCPyV) large and small T antigens (LT and ST). Despite deep genetic differences b
Externí odkaz:
https://doaj.org/article/31f00fa0795e4d19a0af10a923b14cf7
Autor:
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna J. Magliozzi, Prafulla C. Gokhale, Vijaya G. Tirunagaru, Robert C. Doebele, James A. DeCaprio
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin with 2 etiologies. Merkel cell polyomavirus (MCPyV) integration is present in about 80% of all MCC. Virus-positive MCC (MCCP) tumors have few somatic mutations and usua
Externí odkaz:
https://doaj.org/article/48d1999c6108493896009222e6cd2895
Autor:
Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, Jonathan D. Stevens, Alan Y.L. Wong, J. Bryan Iorgulescu, Anna Y. Tarren, Vipheaviny A. Chea, Isabel P. Carulli, Camilla K. Lemvigh, Christina B. Pedersen, Ashley K. Gartin, Siranush Sarkizova, Kyle T. Wright, Letitia W. Li, Jason Nomburg, Shuqiang Li, Teddy Huang, Xiaoxi Liu, Lucas Pomerance, Laura M. Doherty, Annie M. Apffel, Luke J. Wallace, Suzanna Rachimi, Kristen D. Felt, Jacquelyn O. Wolff, Elizabeth Witten, Wandi Zhang, Donna Neuberg, William J. Lane, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu, Derin B. Keskin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
Cancers avoid immune surveillance through an array of mechanisms, including perturbation of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I–low, neuroendocrine carcinoma of the skin often caused by the Merkel c
Externí odkaz:
https://doaj.org/article/60397b52dbf342a38a8b4cfb3371eac6
Publikováno v:
Journal of Investigative Dermatology. 143:166-169.e5
Autor:
Yoshihiro Morimoto, Atsushi Fushimi, Nami Yamashita, Masayuki Hagiwara, Atrayee Bhattacharya, Jingwei Cheng, Thomas C. Frost, Rehan Ahmad, Tatsuaki Daimon, Lei Huang, Tsuyoshi Hata, Hidekazu Takahashi, Masaaki Yamamoto, Yozo Suzuki, James A. DeCaprio, Donald Kufe
Publikováno v:
Oncogene. 41(27)
Merkel cell carcinoma (MCC) is an aggressive malignancy with neuroendocrine (NE) features, limited treatment options, and a lack of druggable targets. There is no reported involvement of the MUC1-C oncogenic protein in MCC progression. We show here t
Autor:
Shobha Vasudevan, Wei Zou, Thomas C Frost, James A. DeCaprio, Matthew Meyerson, Jason Nomburg, Chandreyee Datta, Gabriel J. Starrett, Michael J. Imperiale
Polyomaviruses (PyV) are ubiquitous pathogens that can cause devastating human diseases. Due to the small size of their genomes, PyV utilize complex patterns of RNA splicing to maximize their coding capacity. Despite the importance of PyV to human di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d343ed89ce022a0b12cde280dca3897
https://doi.org/10.1101/2021.11.12.468421
https://doi.org/10.1101/2021.11.12.468421
Autor:
Ashley K. Gartin, Thomas C. Frost, Camille H. Cushman, Brittaney A. Leeper, Prafulla C. Gokhale, James A. DeCaprio
Publikováno v:
Journal of Investigative Dermatology. 142:2783-2792.e15
Polycomb repressive complex 2 has a critical role in the maintenance of bivalent promoters and is often perturbed in cancer, including neuroendocrine tumors. In this study, we investigated the susceptibility of Merkel cell carcinoma (MCC), a neuroend
Autor:
Varsha Ananthapadmanabhan, Thomas C. Frost, Kara M. Soroko, Aine Knott, Brianna Magliozzi, Prafulla C. Gokhale, Vijaya Tirunagaru, Robert C. Doebele, James A. DeCaprio
Publikováno v:
Journal of Investigative Dermatology. 142:2837
Autor:
Derin B. Keskin, Patrick C. Lee, Susan Klaeger, Phuong M. Le, Keegan Korthauer, Jingwei Cheng, Varsha Ananthapadmanabhan, Thomas C. Frost, J. Bryan Iorgulescu, Camilla K. Lemvigh, Christina B. Pedersen, Siranush Sarkizova, Shuqiang Li, Xiaoxi Liu, Laura M. Doherty, Donna Neuberg, Guanglan Zhang, Lars R. Olsen, Manisha Thakuria, Scott J. Rodig, Karl R. Clauser, Gabriel J. Starrett, John G. Doench, Sara J. Buhrlage, Steven A. Carr, James A. DeCaprio, Catherine J. Wu
Publikováno v:
Journal of Investigative Dermatology. 142:2838