Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Thomas C Boothby"'
Autor:
Shraddha KC, Kenny H Nguyen, Vincent Nicholson, Annie Walgren, Tony Trent, Edith Gollub, Paulette Sofia Romero-Perez, Alex S Holehouse, Shahar Sukenik, Thomas C Boothby
Publikováno v:
eLife, Vol 13 (2024)
The conformational ensemble and function of intrinsically disordered proteins (IDPs) are sensitive to their solution environment. The inherent malleability of disordered proteins, combined with the exposure of their residues, accounts for this sensit
Externí odkaz:
https://doaj.org/article/68e5334fa09a44b89622454bfe66b813
Autor:
Jacob Loeffelholz, Emma Meese, Ilaria Giovannini, Karsyn Ullibarri, Sogol Momeni, Nicholas Merfeld, Jessica Wessel, Roberto Guidetti, Lorena Rebecchi, Thomas C. Boothby
Publikováno v:
Biology Open, Vol 13, Iss 10 (2024)
Externí odkaz:
https://doaj.org/article/f4b0d7804fae493a813f334c1aa3fb8f
Publikováno v:
eLife, Vol 13 (2024)
Tiny animals known as tardigrades use a combination of DNA repair machinery and a novel protein to mend their genome after intense ionizing radiation.
Externí odkaz:
https://doaj.org/article/c748d4f614704b1ba818af822a64ce41
Publikováno v:
Frontiers in Materials, Vol 11 (2024)
Water is essential for all active life processes. Despite this, there are a number of organisms that can survive prolonged desiccation. The vitrification hypothesis posits that such organisms survive desiccation by forming non-crystalline amorphous (
Externí odkaz:
https://doaj.org/article/2c00cb29813c43ca970ed9526cedbd87
Publikováno v:
BBA Advances, Vol 5, Iss , Pp 100115- (2024)
Water is essential for metabolism and all life processes. Despite this, many organisms distributed across the kingdoms of life survive near-complete desiccation or anhydrobiosis. Increased intracellular viscosity, leading to the formation of a vitrif
Externí odkaz:
https://doaj.org/article/baaf9713194546b39b9e6b93283d80e8
Autor:
Silvia Sanchez-Martinez, John F. Ramirez, Emma K. Meese, Charles A. Childs, Thomas C. Boothby
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Tardigrades are a group of microscopic animals renowned for their ability to survive near complete desiccation. A family of proteins, unique to tardigrades, called Cytoplasmic Abundant Heat Soluble (CAHS) proteins are necessary to mediate ro
Externí odkaz:
https://doaj.org/article/1e248e2b2bdd48948b9bf44140a395fc
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5bdc0c882ced499fb6fd10ad17996b68
Autor:
Maxwell H. Packebush, Silvia Sanchez-Martinez, Sourav Biswas, Shraddha KC, Kenny H. Nguyen, John F. Ramirez, Vincent Nicholson, Thomas C. Boothby
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Biologics, pharmaceuticals containing or derived from living organisms, such as vaccines, antibodies, stem cells, blood, and blood products are a cornerstone of modern medicine. However, nearly all biologics have a major deficiency: they are
Externí odkaz:
https://doaj.org/article/a0ec4c6803bb4e4594bb07447e03d93d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The disaccharide trehalose is a synergistic cosolute and key biomarker of desiccation tolerance in tardigrades.
Externí odkaz:
https://doaj.org/article/a7ee0d341c234f4f9dbdabfcc6cc1305
Autor:
Ilaria Giovannini, Thomas C. Boothby, Michele Cesari, Bob Goldstein, Roberto Guidetti, Lorena Rebecchi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Water unavailability is an abiotic stress causing unfavourable conditions for life. Nevertheless, some animals evolved anhydrobiosis, a strategy allowing for the reversible organism dehydration and suspension of metabolism as a direct respon
Externí odkaz:
https://doaj.org/article/576329eb994c485e82ed1695695cab08