Zobrazeno 1 - 10
of 645
pro vyhledávání: '"Thomas C, Südhof"'
Autor:
Ji Won Um, Gopal Pramanik, Ji Seung Ko, Min-Young Song, Dongmin Lee, Hyun Kim, Kang-Sik Park, Thomas C. Südhof, Katsuhiko Tabuchi, Jaewon Ko
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114646- (2024)
Externí odkaz:
https://doaj.org/article/eb865ca898fa43c88f7ab62825c62ce3
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002599 (2024)
Synaptic adhesion molecules (SAMs) are evolutionarily conserved proteins that play an important role in the form and function of neuronal synapses. Teneurins (Tenms) and latrophilins (Lphns) are well-known cell adhesion molecules that form a transsyn
Externí odkaz:
https://doaj.org/article/1de0bfe220a04bc1af7e0884284d674d
Autor:
Alessandra Sclip, Thomas C. Südhof
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Synaptic adhesion molecules (SAMs) shape the structural and functional properties of synapses and thereby control the information processing power of neural circuits. SAMs are broadly expressed in the brain, suggesting that they may instruct
Externí odkaz:
https://doaj.org/article/c0aa8ca41e9a40ba981dbad74dc9b82c
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0298645 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0158295.].
Externí odkaz:
https://doaj.org/article/ba095ef9025f45de8c2144a968a9cec1
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
The presynaptic release probability is a major determinant of synaptic transmission in brain. Here, the authors show that a trans-synaptic signaling complex comprising presynaptic Neurexin-3 and postsynaptic dystroglycan controls the release probabil
Externí odkaz:
https://doaj.org/article/b4ea889eebb84b5e8ea3ec8edd3cdf02
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/330d39682ab447e2ba5caca0492ccf58
Autor:
Bahareh Haddad Derafshi, Tamas Danko, Soham Chanda, Pedro J. Batista, Ulrike Litzenburger, Qian Yi Lee, Yi Han Ng, Anu Sebin, Howard Y. Chang, Thomas C. Südhof, Marius Wernig
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-28 (2022)
Abstract The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is a chromat
Externí odkaz:
https://doaj.org/article/f6144c8eb12747dd9d2726213f094bb0
Autor:
Scott R. Burlingham, Nicole F. Wong, Lindsay Peterkin, Lily Lubow, Carolina Dos Santos Passos, Orion Benner, Michael Ghebrial, Thomas P. Cast, Matthew A. Xu-Friedman, Thomas C. Südhof, Soham Chanda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Neuronal communication relies on matching different neurostransmitter types with their appropriate receptors. The authors here demonstrate that release of a novel neurotransmitter from presynaptic terminals can induce both the accumulation and activa
Externí odkaz:
https://doaj.org/article/9d882e0d844f4effa3e0531c399f808b
Autor:
Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-28 (2022)
Abstract Background The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identifie
Externí odkaz:
https://doaj.org/article/b7ff67c9372c446f969eb6ed5f640478
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Extensive studies concluded that homophilic interactions between pre- and postsynaptic teneurins, evolutionarily conserved cell-adhesion molecules, encode the specificity of synaptic connections. However, no direct evidence is available to d
Externí odkaz:
https://doaj.org/article/cf869f3008a44d5cbfaf8b162b69fd9f