Delineation of human prostate cancer evolution identifies chromothripsis as a polyclonal event and FKBP4 as a potential driver of castration resistance

Autor: Thomas C. Gasser, Tanja Dietsche, Cristina Quintavalle, Cyrill A. Rentsch, Thomas Lorber, Elisabeth Lenkiewicz, Christian Ruiz, Valeria Perrina, Michael T. Barrett, David C Müller, Tobias Zellweger, Joel R Federer-Gsponer, Darius Juskevicius, Lukas Bubendorf

Publikováno v: The Journal of Pathology. 245:74-84

Understanding the evolutionary mechanisms and genomic events leading to castration-resistant (CR) prostate cancer (PC) is key to improve the outcome of this otherwise deadly disease. Here, we delineated the tumour history of seven patients progressin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d8a83040271592643b241bcd6c048b
https://doi.org/10.1002/path.5052

p53 protein expression but not mdm-2 protein expression is associated with rapid tumor cell proliferation and prognosis in renal cell carcinoma

Autor: Athanassios Dellas, Michael J. Mihatsch, Feng Jiang, Jan Richter, Thomas C. Gasser, Guido Sauter, Lukas Bubendorf, Holger Moch, N Buchholz

The clinical course of renal cell carcinoma (RCC) is highly variable. Overexpression of the p53 protein has been suggested as a possible prognostic parameter in RCC. Overexpression of the mdm-2 oncogene product has been shown to interact with the p53

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bece107ee5eb2996256a8a6e59d3a1
http://doc.rero.ch/record/317847/files/240_2004_Article_BF00942044.pdf

Contributors

Autor: Clayton Adam, Davide Ambrosi, Peter Anderson, Stéphane Avril, Thiranja P. Babarenda Gamage, Pierre Badel, Chiara Bellini, Silvia S. Blemker, Mohamed Bader Boubaker, Peter H.M. Bovendeerd, Marek Bucki, Begonã Calvo, Francis Cannard, Matthieu Chabanas, Grégory Chagnon, Simon Chatelin, Hadrien Courtecuisse, Nicolas Curt, Christian J. Cyron, Tammo Delhaas, Hervé Delingette, Elena S. Di Martino, Raphaël Dumas, Olivier Dupuis, Denis Favier, Sidney Fels, Behrooz Fereidoonnezhad, Gérard Finet, Cormac Flynn, Fanny Frauziols, Jean-François Ganghoffer, Alberto Garcia, Thomas C. Gasser, Ahmed M. Gharib, Paul Glass, Hans Gregersen, Negar M. Harandi, Nicolas Hermant, Belén Hernández-Gascón, Andrew Ho, Gerhard A. Holzapfel, Jay D. Humphrey, Yoann Lafon, Sébastien Laporte, Donghua Liao, Vincent Luboz, Mauro Malvè, Stéphanie Marchesseau, Jean-Louis Martiel, Scott Moisik, Jérôme Molimard, Fanny Morin, Martyn P. Nash, Laurent Navarro, Mohammad Ali Nazari, Poul M.F. Nielsen, Jacques Ohayon, Cees W.J. Oomens, Yohan Payan, Estefanía Peña, Pascal Perrier, Antoine Perrier, Gerrit W.M. Peters, Roderic I. Pettigrew, Dominique P. Pioletti, Marieke Pluijmert, Lalao Rakotomanana, Pierre-Yves Rohan, Philippe Rouch, C. Antonio Sánchez, Wafa Skalli, Ian Stavness, Julien Stelletta, Keyi Tang, Maxim Van den Abbeele, Marc van Vijven, Arne Vogel, Nicolas Vuillerme, John S. Wilson, Saami K. Yazdani, Florence Zara, Jingbo Zhao

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::109a303f009c09b8f6a422050599cdca
https://doi.org/10.1016/b978-0-12-804009-6.09991-0

Potential Consequences of Low Biopsy Core Number in Selection of Patients With Prostate Cancer for Current Active Surveillance Protocols

Autor: Georg Müller, Alexander Bachmann, Thomas C. Gasser, Gernot Bonkat, Cyrill A. Rentsch, Heike Püschel, Stephen Wyler, Lukas Bubendorf, Malte Rieken

Publikováno v: Urology. 81:837-843

To compare the performance of the Epstein criteria and the Prostate Cancer Research International: Active Surveillance (PRIAS) criteria in the identification of patients eligible for active surveillance (AS) but treated with radical prostatectomy.We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce884c31354e7767cc88cc138097ce8
https://doi.org/10.1016/j.urology.2012.10.068

Comparison of the roll-plate and sonication techniques in the diagnosis of microbial ureteral stent colonisation: results of the first prospective randomised study

Autor: Andreas F. Widmer, Stephen Wyler, Georg Müller, Thomas C. Gasser, Gernot Bonkat, Reno Frei, Malte Rieken, Andre van der Merwe, Alexander Bachmann, Fabian Siegel, Olivier Braissant

Publikováno v: World Journal of Urology. 31:579-584

Background: Microbial ureteral stent colonisation (MUSC) is one leading risk factor for complications associated with ureteral stent placement. As MUSC remains frequently undetected by standard urine cultures, its definitive diagnosis depends on micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a10d53271a6993a3797b621457f3ce
https://doi.org/10.1007/s00345-012-0963-5