Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Thomas C, Britton"'
Autor:
Mark J. Benvenga, Stephen F. Chaney, Melvyn Baez, Thomas C. Britton, William J. Hornback, James A. Monn, Gerard J. Marek
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive
Externí odkaz:
https://doaj.org/article/9f965940a60d4dd5ac6205b068ebae96
Autor:
Daniel D. Moerder, Michael J. Acheson, Thomas C. Britton, Natasha A. Neogi, Barton J. Bacon, Benjamin M. Simmons, Jon Holbrook, Jared A. Grauer, Newton H. Campbell, Irene M. Gregory, Jacob Cook, Patrick C. Murphy
Publikováno v:
Lecture Notes in Computer Science ISBN: 9783030617240
DDDAS
DDDAS
The advent of third aviation revolution that is seeking to enable transportation where users have access to immediate and flexible air travel. The users dictate trip origin, destination and timing. One of the major components of this vision is urban
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d83b8798d738602939c9116227b89b
https://doi.org/10.2514/6.2021-1000
https://doi.org/10.2514/6.2021-1000
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067
Autor:
Mark J, Benvenga, Stephen F, Chaney, Melvyn, Baez, Thomas C, Britton, William J, Hornback, James A, Monn, Gerard J, Marek
Publikováno v:
Frontiers in Pharmacology
There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0af9b23c7f0343c501750daec48ed5
https://pubmed.ncbi.nlm.nih.gov/29599719
https://pubmed.ncbi.nlm.nih.gov/29599719
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967
Autor:
Bruce A. Dressman, Veronique Dehlinger, Rosa Maria A. Simmons, Smriti Iyengar, Steven Marc Massey, John T. Catlow, David L. McKinzie, Langu Peng, Adam M. Fivush, Edda F. Roberts, Barry Peter Clark, Mallorie R. Bracey-Walker, James A. Monn, Junliang Hao, Steven C. Peters, Steven S. Henry, Beverly A. Heinz, Sean P. Hollinshead, Anita D. Tepool, Steven Swanson, Patrick L. Love, Thomas C. Britton, Helene Rudyk, Benjamin Paul Vokits
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1249-1252
A novel series of selective negative allosteric modulators (NAMs) for metabotropic glutamate receptor 5 (mGlu5) was discovered from an isothiazole scaffold. One compound of this series, (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef86f59bea2ecb1e4670f9d5e462c59f
https://doi.org/10.1016/j.bmcl.2013.01.009
https://doi.org/10.1016/j.bmcl.2013.01.009
Autor:
Gary Gilmour, Dale M. Edgar, Francois Gastambide, Lorena Taboada, Beverly A. Heinz, Elaine Shanks, Brian G. Getman, Lourdes Prieto, Janice W. Smith, Lisa M. Broad, Thomas C. Britton, Keith A. Wafford, Adam M. Fivush, Mark D. Tricklebank, Andrew McCarthy, Ellen M. Colvin
Publikováno v:
Neuropharmacology. 64:224-239
The demonstrated functional interaction of metabotropic glutamate 5 (mGlu₅) receptors with N-methyl-d-aspartate (NMDA) receptors has prompted speculation that their activation may offer a potential treatment for aspects of schizophrenia. Developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::499e6fd6587a804b5c1c9dc77cbb6b56
https://doi.org/10.1016/j.neuropharm.2012.07.030
https://doi.org/10.1016/j.neuropharm.2012.07.030