Zobrazeno 1 - 10 of 115 pro vyhledávání: '"Thomas Brittain"'
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Akademický článek
The Anti-Apoptotic Role of Neuroglobin
Autor: Thomas Brittain
Publikováno v: Cells, Vol 1, Iss 4, Pp 1133-1155 (2012)
The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range
Externí odkaz: https://doaj.org/article/26e230619170484980078b2f63000837
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4
A Futile Redox Cycle Involving Neuroglobin Observed at Physiological Temperature
Autor: Anyang Liu, Thomas Brittain
Publikováno v: International Journal of Molecular Sciences
Volume 16
Issue 8
Pages 20082-20094
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 20082-20094 (2015)
Previous studies identifying the potential anti-apoptotic role of neuroglobin raise the question as to how cells might employ neuroglobin to avoid the apoptotic impact of acute hypoxia whilst also avoiding chronic enhancement of tumour formation. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db69957f073e6cfa6bac57f049a3e779
https://doi.org/10.3390/ijms160820082
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5
An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: Application to neuroserpin reveals regions that differentially regulate inhibitory activity
Autor: Annie Shu-Ping Yang, Tet Woo Lee, Nigel P. Birch, Thomas Brittain
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 83:135-152
The analysis of sequence conservation is commonly used to predict functionally important sites in proteins. We have developed an approach that first identifies highly conserved sites in a set of orthologous sequences using a weighted substitution-mat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6acbad12b0b40b6027586c55d2323ccd
https://doi.org/10.1002/prot.24711
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6
Mutational Analysis of Cysteine Residues of the Insect Odorant Co-receptor (Orco) from Drosophila melanogaster Reveals Differential Effects on Agonist- and Odorant-tuning Receptor-dependent Activation
Autor: Brijesh Kumar, Richard D. Newcomb, Laurence J. Zwiebel, Rebecca M. Turner, Stephen L. Derryberry, David L. Christie, Thomas Brittain
Publikováno v: Journal of Biological Chemistry. 289:31837-31845
Insect odorant receptors are heteromeric odorant-gated cation channels comprising a conventional odorant-sensitive tuning receptor (ORx) and a highly conserved co-receptor known as Orco. Orco is found only in insects, and very little is known about i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab83ea4fda17b5d22453ac89fbd7453a
https://doi.org/10.1074/jbc.m114.603993
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7
Novel haemoglobin mutation (α127Lys→Glu) increases oxygen affinity and has a minor effect on haptoglobin binding
Autor: Stephen O. Brennan, Thomas Brittain, Maurice C. Owen, Beverley M. Pullon
Publikováno v: Clinical Biochemistry. 45:1587-1590
Objectives To determine if a new haemoglobin (Hb) variant was the underlying cause of erythrocytosis in a subject with a high apparent HbA1c. Design and method Haemolysate was analysed by ESI MS, and individual components purified by ion exchange and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b510b5555a3c1fb21dfbdcc9ae484453
https://doi.org/10.1016/j.clinbiochem.2012.08.021
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8
Does a redox cycle provide a mechanism for setting the capacity of neuroglobin to protect cells from apoptosis?
Autor: Joanna Skommer, Thomas Brittain
Publikováno v: IUBMB Life. 64:419-422
We hypothesize that the various, previously reported, reactivities of neuroglobin with redox partners and oxygen provide for the establishment of a redox cycle within cells, such as neurons and retinal rod cells. Using native cell lysates, from cultu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267cdcb2bd63c65b81cab3844d5b2eba
https://doi.org/10.1002/iub.566
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9
The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes
Autor: Garth J. S. Cooper, Thomas Brittain, Kerry M. Loomes, Vita Chien, Jacqueline F. Aitken, Shaoping Zhang, Christina M. Buchanan, Anthony J. R. Hickey
Publikováno v: Biochemical Journal. 432:113-121
Misfolding of the islet β-cell peptide hA (human amylin) into β-sheet-containing oligomers is linked to β-cell apoptosis and the pathogenesis of T2DM (Type 2 diabetes mellitus). In the present study, we have investigated the possible effects on hA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa60a5363bafd38f8491b70988cdd865
https://doi.org/10.1042/bj20100434
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10
An Antiapoptotic Neuroprotective Role for Neuroglobin
Autor: Joanna Skommer, Subadhip Raychaudhuri, Nigel P. Birch, Thomas Brittain
Publikováno v: International Journal of Molecular Sciences, Vol 11, Iss 6, Pp 2306-2321 (2010)
International Journal of Molecular Sciences
Cell death associated with mitochondrial dysfunction is common in acute neurological disorders and in neurodegenerative diseases. Neuronal apoptosis is regulated by multiple proteins, including neuroglobin, a small heme protein of ancient origin. Neu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e004049874c4799baf91ac4f400dbb
https://doi.org/10.3390/ijms11062306
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