Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Thomas Brinz"'
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Akademický článek
A Semi-Automated DEM Parameter Calibration Technique of Powders Based on Different Bulk Responses Extracted from Auger Dosing Experiments
Autor: Bilal El Kassem, Nizar Salloum, Thomas Brinz, Yousef Heider, Bernd Markert
Publikováno v: KONA Powder and Particle Journal, Vol 38, Iss 0, Pp 235-250 (2020)
Discrete Element Method (DEM) proved to be an essential tool to optimize the industrial auger dosing process for pharmaceutical powders. During the DEM parameter calibration process of a certain powder, several parameter combinations might lead to a
Externí odkaz: https://doaj.org/article/b32439d212c845d9bc09e3b289dcaae5
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2
Design of a vertical Loss-in-Weight feeder prototype with experimental proof of concept validation
Autor: Yousef Heider, Vahid Jenkouk, Bernd Markert, Bilal El Kassem, Thomas Brinz
Publikováno v: Pharmaceutical Development and Technology. 26:559-575
Loss-in-Weights (LiW) feeders are commonly oriented in a horizontal way. In this work, an experimental proof of concept, including mechanical and electrical design, construction, and operation, of a vertical LiW feeder prototype is performed. In a sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c541099ce07a49c545894bf35865f797
https://doi.org/10.1080/10837450.2021.1901915
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3
Powder flow and mixing in different tablet press feed frames
Autor: Stefan Manz, Peter Toson, Johannes Khinast, Torsten Grass, Thomas Forgber, Michael Martinetz, Thomas Brinz, Eva Siegmann, Hermann Kureck
Publikováno v: Advanced Powder Technology. 31:770-781
Tablets can be manufactured using a rotary tablet press, which consists of a feed frame followed by the compression and compaction of the powder and subsequent ejection of the tablets. From Quality by Design (QbD) perspectives the feed frame plays a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82742decda9cdfaceb27e3843ff98d72
https://doi.org/10.1016/j.apt.2019.11.031
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4
Deriving control parameter settings from process models to control capsule fillers integrated into continuous manufacturing
Autor: Thomas Brinz, Shea Fen Cheong, Johannes Khinast, Bernhard Wagner
Publikováno v: Drug Development and Industrial Pharmacy. 45:1523-1536
The aim of this work was to investigate the mean fill weight control of a continuous capsule-filling process, whether it is possible to derive controller settings from an appendant process model. To that end, a system composed out of fully automated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852e25138b1dd31e6b5b094334d6e9f0
https://doi.org/10.1080/03639045.2019.1634093
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5
A Semi-Automated DEM Parameter Calibration Technique of Powders Based on Different Bulk Responses Extracted from Auger Dosing Experiments
Autor: Thomas Brinz, Bilal El Kassem, Yousef Heider, Bernd Markert, Nizar Salloum
Publikováno v: KONA : powder and particle 38, 235-250 (2020). doi:10.14356/kona.2021010
KONA Powder and Particle Journal, Vol 38, Iss 0, Pp 235-250 (2020)
KONA ?, 2021010 (2020). doi:10.14356/kona.2021010
Published by Osaka
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c5cb45aea25e1cf0d9046b98e73471
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7
Automation of a dosing-disc capsule filler from the perspective of reliability and safety
Autor: Bernhard Wagner, Stephanie Otterbach, Johannes Khinast, Thomas Brinz
Publikováno v: Drug Development and Industrial Pharmacy. 44:502-510
The aim of this paper is to explore the possibility to develop an automatically adjustable, reliable, and safe capsule filling operation. Process parameters that are critical for the tamping pin process were reviewed based on the literature and via e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8c43760d24772907d8dd47dbddb5ed
https://doi.org/10.1080/03639045.2017.1402920
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8
Using online content uniformity measurements for rapid automated process development exemplified via an X-ray system
Autor: Thomas Brinz, Johannes Khinast, Bernhard Wagner
Publikováno v: Pharmaceutical development and technology. 24(6)
This paper addresses the relevance of automated content testing for the rapid automated process development (RAPD). Our previous work demonstrated that RAPD allowed a fast and efficient development of a continuous capsule-filling process. Target was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97dac5ffae4bab720134437a0d769cd
https://pubmed.ncbi.nlm.nih.gov/31023115
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10
A multivariate statistical approach to analyze the impact of material attributes and process parameters on the quality performance of an auger dosing process
Autor: Yousef Heider, Bernd Markert, Thomas Brinz, Bilal El Kassem
Publikováno v: Journal of Drug Delivery Science and Technology. 60:101950
The purpose of this work is to develop a statistical methodology that identifies the correlations among critical material attributes, critical process parameters, and critical quality attributes of a volumetric vertical micro-auger dosing process. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90d84f3a7be69f289a3aa01582c58705
https://doi.org/10.1016/j.jddst.2020.101950
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