Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Thomas Bouillon"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 348-361 (2022)
Abstract Before investing resources into the development of a precision dosing (model‐informed precision dosing [MIPD]) tool for tacrolimus, the performance of the tool was evaluated in silico. A retrospective dataset of 315 de novo kidney transpla
Externí odkaz:
https://doaj.org/article/771e2ce1da574f3791df4931f5bf3f10
Autor:
Nina Nauwelaerts, Julia Macente, Neel Deferm, Rodolfo Hernandes Bonan, Miao-Chan Huang, Martje Van Neste, David Bibi, Justine Badee, Frederico S. Martins, Anne Smits, Karel Allegaert, Thomas Bouillon, Pieter Annaert
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1469 (2023)
Women commonly take medication during lactation. Currently, there is little information about the exposure-related safety of maternal medicines for breastfed infants. The aim was to explore the performance of a generic physiologically-based pharmacok
Externí odkaz:
https://doaj.org/article/11f1b5bd790e446a9b2a3b6512657899
Autor:
Ruben Faelens, Zhigang Wang, Thomas Bouillon, Paul Declerck, Marc Ferrante, Séverine Vermeire, Erwin Dreesen
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1623 (2021)
Model-informed precision dosing (MIPD) may be a solution to therapeutic failure of infliximab for patients with ulcerative colitis (UC), as underexposure could be avoided, and the probability of endoscopic improvement (pEI; Mayo endoscopic subscore
Externí odkaz:
https://doaj.org/article/75ab0da1d3884c42aa405c7d78d87b02
Publikováno v:
The FASEB Journal. 36
Autor:
Marc Jacquemin, Ines Van den bosch, Thomas Vanassche, Maarten Coemans, Thomas Bouillon, Björn Meijers, Dirk Kuypers, Peter Verhamme
Background Apixaban, a direct oral anticoagulant inhibiting factor Xa, has been proven to reduce the risk of atrial fibrillation-related stroke and thromboembolism in patients with mild to moderate renal insufficiency. Patients on renal replacement t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49d81c1ddfcbfcc724fa2251138be2f
https://lirias.kuleuven.be/handle/20.500.12942/686191
https://lirias.kuleuven.be/handle/20.500.12942/686191
Publikováno v:
British Journal of Clinical Pharmacology, 87(4), 2089-2097. Wiley-Blackwell Publishing Ltd
Aims: Develop a population pharmacokinetic model describing propofol pharmacokinetics in (pre)term neonates and infants, that can be used for precision dosing (e.g. during target-controlled infusion) of propofol in this population. Methods: A nonline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3c280beecbff530d41d12f642a5423
https://doi.org/10.22541/au.158920718.80707706
https://doi.org/10.22541/au.158920718.80707706
Publikováno v:
Clinical Pharmacology & Therapeutics. 102:989-996
Whether the combined use of probe drugs for CYP3A4 and P-glycoprotein can clarify the relative contribution of these proteins to pharmacokinetic variability of a dual substrate like tacrolimus has never been assessed. Seventy renal recipients underwe
Autor:
Pieter Annaert, Mathieu Vinken, Tom De Vocht, Bing Qi, Peter de Witte, Neel Deferm, Eva Gijbels, Thomas Bouillon, Pieter Van Brantegem
Drug-induced cholestasis (DIC) poses a major challenge to the pharmaceutical industry and regulatory agencies. It causes both drug attrition and post-approval withdrawal of drugs. DIC represents itself as an impaired secretion and flow of bile, leadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa862b14a6269d72a5b4716ef970212
https://doi.org/10.1080/10408444.2019.1635081
https://doi.org/10.1080/10408444.2019.1635081
Autor:
Ann Gils, Erwin Dreesen, Marc Ferrante, Wannee Kantasiripitak, Thomas Bouillon, David Drobne, Iris Detrez, Sebastian Stefanovic, Severine Vermeire
Publikováno v:
Inflammatory Bowel Diseases.
Background Unlike other anti–tumor necrosis factor alpha antibodies, golimumab does not deliver on its promise of effectiveness for treating patients with ulcerative colitis. We investigated the value of therapeutic drug monitoring for optimizing g
Autor:
Neel, Deferm, Lysiane, Richert, Pieter, Van Brantegem, Tom, De Vocht, Bing, Qi, Peter, de Witte, Thomas, Bouillon, Pieter, Annaert
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1981
Drug-induced cholestasis poses a major hurdle for the pharmaceutical industry as it is one the primary mechanisms of drug-induced liver injury. Hence, detection of drug-induced cholestasis during the early stages of drug development is of utmost impo