Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas Botton"'
Autor:
Ana C. B. Sant'Anna‐Silva, Thomas Botton, Andrea Rossi, Jochen Dobner, Hanene Bzioueche, Nguyen Thach, Lauriane Blot, Sophie Pagnotta, Konrad Kleszczynski, Kerstin Steinbrink, Nathalie M. Mazure, Stéphane Rocchi, Jean Krutmann, Thierry Passeron, Meri K. Tulic
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/9305f8c0f89f41ec8074cb830bcb975d
Autor:
Emilie Jaune, Elisa Cavazza, Cyril Ronco, Oleksandr Grytsai, Patricia Abbe, Nedra Tekaya, Marwa Zerhouni, Guillaume Beranger, Lisa Kaminski, Frédéric Bost, Maeva Gesson, Meri Tulic, Paul Hofman, Robert Ballotti, Thierry Passeron, Thomas Botton, Rachid Benhida, Stéphane Rocchi
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and ce
Externí odkaz:
https://doaj.org/article/0dea28988f794e45baced1a544ab1909
Autor:
Thomas Botton, Eric Talevich, Vivek Kumar Mishra, Tongwu Zhang, A. Hunter Shain, Céline Berquet, Alexander Gagnon, Robert L. Judson, Robert Ballotti, Antoni Ribas, Meenhard Herlyn, Stéphane Rocchi, Kevin M. Brown, Nicholas K. Hayward, Iwei Yeh, Boris C. Bastian
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 573-588.e7 (2019)
Summary: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected hete
Externí odkaz:
https://doaj.org/article/0cc277c61e1b4388ac070ad9ad16b2a2
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 4, p e1004873 (2016)
Germline copy number variants (CNVs) and somatic copy number alterations (SCNAs) are of significant importance in syndromic conditions and cancer. Massively parallel sequencing is increasingly used to infer copy number information from variations in
Externí odkaz:
https://doaj.org/article/129f9c385a4d444aa5dadcf5f65a1770
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e15400 (2010)
The small Rho G-protein Rac1 is highly conserved from fungi to humans, with approximately 65% overall sequence identity in Candida albicans. As observed with human Rac1, we show that C. albicans Rac1 can accumulate in the nucleus, and fluorescence re
Externí odkaz:
https://doaj.org/article/3ff508bab04740159580a8b0ed207777
Autor:
Tongwu Zhang, Nicholas K. Hayward, Boris C. Bastian, Kevin M. Brown, Iwei Yeh, Meenhard Herlyn, A. Hunter Shain, Robert L. Judson, Céline Berquet, Thomas Botton, Eric Talevich, Vivek Mishra, Antoni Ribas, Alexander Gagnon, Robert Ballotti, Stéphane Rocchi
Publikováno v:
Cell Reports, Vol 29, Iss 3, Pp 573-588.e7 (2019)
Cell reports, vol 29, iss 3
Cell reports, vol 29, iss 3
Summary: BRAF fusions are detected in numerous neoplasms, but their clinical management remains unresolved. We identified six melanoma lines harboring BRAF fusions representative of the clinical cases reported in the literature. Their unexpected hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d5b0c1b10f4dcbbea49bae116d00b8
http://www.sciencedirect.com/science/article/pii/S2211124719311866
http://www.sciencedirect.com/science/article/pii/S2211124719311866
Publikováno v:
Journal of Clinical Pathology. 73:524-525
We read with great interest the article from Le Flahec and colleagues encouraging the testing for BRAF fusions in patients with advanced BRAF/NRAS/KIT wild-type melanomas.1 As emphasised in the article, the only viable therapeutic option currently av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d797a789fff74c87d438bca87df6a198
https://doi.org/10.1136/jclinpath-2019-206366
https://doi.org/10.1136/jclinpath-2019-206366
Autor:
Takeshi Isoyama, Maria C. Garrido, Alexander Gagnon, Boris C. Bastian, Kenji Nakamaru, A. Hunter Shain, Timothy H. McCalmont, Thomas Botton, Iwei Yeh, Philip E. LeBoit, Swapna S. Vemula, Meng Kian Tee, Alyssa J. Sparatta
Publikováno v:
The Journal of Pathology. 240:282-290
Oncogenic fusions in TRK family receptor tyrosine kinases have been identified in several cancers and can serve as therapeutic targets. We identified ETV6-NTRK3, MYO5A-NTRK3 and MYH9-NTRK3 fusions in Spitz tumours, and demonstrated that NTRK3 fusions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b244135d449faad29045b5130c245a
https://doi.org/10.1002/path.4775
https://doi.org/10.1002/path.4775
Autor:
Eric A. Collisson, Huat Chye Lim, Phil Stephens, Spencer C. Behr, Robin Kate Kelley, Meagan Montesion, John D. Gordan, Thomas Botton, Sarah E. Umetsu
Publikováno v:
The oncologist, vol 23, iss 9
Biliary tract cancers such as cholangiocarcinoma represent a heterogeneous group of cancers that can be difficult to diagnose. Recent comprehensive genomic analyses in large cholangiocarcinoma cohorts have defined important molecular subgroups within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30aea57f924c4c7000a8e0ab43c5eb2
https://escholarship.org/uc/item/3jc108qt
https://escholarship.org/uc/item/3jc108qt
Autor:
Jue Lin, Hanlin Zeng, Aparna Jorapur, Andrew S. McNeal, Matthew Donne, Nancy M. Joseph, Ingmar N. Bastian, Laura B. Pincus, A. Hunter Shain, Thomas Botton, Yuntian Zhang, Rodrigo Torres, Iwei Yeh, Robert L. Judson, Ursula E. Lang, Beth S. Ruben, Boris C. Bastian, Jeffrey P. North, Richard Yu
Publikováno v:
Cancer cell, vol 34, iss 1
Loss of the CDKN2A tumor suppressor is associated with melanoma metastasis, but the mechanisms connecting the phenomena are unknown. Using CRISPR-Cas9 to engineer a cellular model of melanoma initiation from primary human melanocytes, we discovered t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97bac0c9ad2d6e25735d633e1169d09
https://europepmc.org/articles/PMC6084788/
https://europepmc.org/articles/PMC6084788/