Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas Bohnacker"'
Autor:
Julie R. Jin, Elena Gogvadze, Ana R. Xavier, Thomas Bohnacker, Jan Voelzmann, Matthias P. Wymann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mast cells are the major effector cells in immunoglobulin E (IgE)-mediated allergy. The high affinity IgE receptor FcεRI, as well as G protein-coupled receptors (GPCRs) on the mast cell surface signals to phosphoinositide 3-kinase γ (PI3Kγ) to ini
Externí odkaz:
https://doaj.org/article/c8269d02e3da4ce8a13fc6f8b59d90e3
Autor:
Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Buparlisib/BKM120 is in phase 3 clinical trials as a phosphoinositide 3-kinase (PI3K) inhibitor. Here, Bohnackeret al. combine chemical biology and structural biology approaches to segregate BKM120’s biological actions, and suggest that it causes m
Externí odkaz:
https://doaj.org/article/a5212909a4a7490db4d79600c172c822
Autor:
Luca Aresu, Serena Ferraresso, Laura Marconato, Luciano Cascione, Sara Napoli, Eugenio Gaudio, Ivo Kwee, Chiara Tarantelli, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Petra Hillmann, Thomas Bohnacker, Matthias P. Wymann, Stefano Comazzi, Massimo Milan, Fulvio Riondato, Giulia Dalla Rovere, Mery Giantin, Diana Giannuzzi, Francesco Bertoni
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/df8e7002c3f442f0a88084a02154e353
Autor:
Joshua J. Anzinger, Janet Chang, Qing Xu, Manoj K. Barthwal, Thomas Bohnacker, Matthias P. Wymann, Howard S. Kruth
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 1, Pp 34-42 (2012)
Accumulation of cholesterol by macrophage uptake of LDL is a key event in the formation of atherosclerotic plaques. Previous research has shown that granulocyte-macrophage colony-stimulating factor (GM-CSF) is present in atherosclerotic plaques and p
Externí odkaz:
https://doaj.org/article/da1b19f23bc64e249a406cf4bd806737
Autor:
Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001587 (2013)
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. PI3Kγ is key to the regulation of immune cell responses activated by G protein-coupled receptor
Externí odkaz:
https://doaj.org/article/70630b19e2284767a532785dcfa64b7a
Autor:
Manoj K Barthwal, Joshua J Anzinger, Qing Xu, Thomas Bohnacker, Matthias P Wymann, Howard S Kruth
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58054 (2013)
During atherosclerosis, low-density lipoprotein (LDL)-derived cholesterol accumulates in macrophages to form foam cells. Macrophage uptake of LDL promotes foam cell formation but the mechanism mediating this process is not clear. The present study in
Externí odkaz:
https://doaj.org/article/5767ea81ee4642daae82cd52267fd62d
Autor:
Matthias P. Wymann, Sauveur-Michel Maira, Bernd Giese, Carlos Garcia-Echeverria, Frédéric Stauffer, Vladimir Cmiljanovic, Christian Schnell, Thomas Bohnacker, Ann C. Mertz, Dominik Erhart, Romina Marone
Supplementary Data from Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9260b847243d0cd1ef1c54f287784d03
https://doi.org/10.1158/1541-7786.22519242.v1
https://doi.org/10.1158/1541-7786.22519242.v1
Autor:
Thomas Bohnacker, Dorothea Gruber, Sara Laudato, Martin Schwill, Charles-Henry Fabritius, Raquel Herrador, Katrin Westritschnig, Thushara Pattupara, Vikram Ayinampudi, Stefanie Flückiger-Mangual
Publikováno v:
Cancer Research. 83:3907-3907
Resistance to targeted therapies is a major challenge in oncology. Disease progression is caused by multiple resistance mechanisms. Besides pre-existing and acquired genetic alternations, adaptive non-mutational reprogramming as well as modulation of
Autor:
Wolfgang Löscher, Denise Rageot, Rohitha Sriramaratnam, Erhan Keles, Petra Hillmann, Matthias Hamburger, Andrea Treyer, Doriano Fabbro, Florent Beaufils, Paul Hebeisen, Anna Melone, Matthias P. Wymann, Martina De Pascale, Lukas Bissegger, Chiara Borsari, Thomas Bohnacker
Publikováno v:
Journal of Medicinal Chemistry. 63:13595-13617
The mechanistic target of rapamycin (mTOR) pathway is hyperactivated in cancer and neurological disorders. Rapalogs and mTOR kinase inhibitors (TORKi) have recently been applied to alleviate epileptic seizures in tuberous sclerosis complex (TSC). Her
Autor:
Chiara Borsari, Doriano Fabbro, Petra Hillmann, Florent Beaufils, Thomas Bohnacker, Matthias P. Wymann, Denise Rageot, Ivan Buslov, Erhan Keles, Alexander M. Sele, Anna Melone, Paul Hebeisen
Publikováno v:
ACS Medicinal Chemistry Letters
The phosphoinositide 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR) pathway is a critical regulator of cell growth and is frequently hyperactivated in cancer. Therefore, PI3K inhibitors represent a valuable asset in cancer therapy. Herein we