Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Thomas Boesen"'
Autor:
Dheeraj Kanaparthi, Marko Lampe, Jan-Hagen Krohn, Baoli Zhu, Falk Hildebrand, Thomas Boesen, Andreas Klingl, Prasad Phapale, Tillmann Lueders
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Protocells are believed to have existed on early Earth prior to the emergence of prokaryotes. Due to their rudimentary nature, it is widely accepted that these protocells lacked intracellular mechanisms to regulate their reproduction, thereb
Externí odkaz:
https://doaj.org/article/ddbc3c14a2e84af5846f9e702bbb8bda
Autor:
Søren K. Amstrup, Sui Ching Ong, Nicholas Sofos, Jesper L. Karlsen, Ragnhild B. Skjerning, Thomas Boesen, Jan J. Enghild, Bjarne Hove-Jensen, Ditlev E. Brodersen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, authors analyse the structural organisation of the large carbon-phosphorus lyase enzyme from bacteria using electron microscopy and discover that it contains two ATP-binding cassette dimers of PhnK and PhnL and opens upon ATP hydrolysis.
Externí odkaz:
https://doaj.org/article/625657f8909c41b5bade23dc3d832d87
Autor:
Aida S. Hansen, Lea S. Jensen, Kristine R. Gammelgaard, Kristoffer G. Ryttersgaard, Christian Krapp, Jesper Just, Kasper L. Jønsson, Pia B. Jensen, Thomas Boesen, Mogens Johannsen, Anders Etzerodt, Bent W. Deleuran, Martin R. Jakobsen
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majori
Externí odkaz:
https://doaj.org/article/243433d9b85349ca81ff3bd193a23e6f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Insoluble α-synuclein (αSyn) filaments in brain tissue are a hallmark of Parkinson’s disease (PD) and Multiple system atrophy (MSA), and for structural studies, they have for decades been extracted using the detergent sarkosyl. We asked if PD and
Externí odkaz:
https://doaj.org/article/ef04c66e5c884339965764dac7764c4e
Autor:
Sara Dam Kobberø, Michael Gajhede, Osman Asghar Mirza, Søren Kløverpris, Troels Rønn Kjær, Jakob Hauge Mikkelsen, Thomas Boesen, Claus Oxvig
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The metalloproteinase PAPP-A promotes insulin-like growth factor (IGF) signaling by cleavage of inhibitory IGF binding proteins. Here, the authors report the 3D structure of PAPP-A in complex with its endogenous inhibitor, stanniocalcin-2.
Externí odkaz:
https://doaj.org/article/dd1bab3f3f344221a1bcddc8c4635e2f
Autor:
Susan Hartmann, Meilee Ling, Lasse S. A. Dreyer, Assaf Zipori, Kai Finster, Sarah Grawe, Lasse Z. Jensen, Stella Borck, Naama Reicher, Taner Drace, Dennis Niedermeier, Nykola C. Jones, Søren V. Hoffmann, Heike Wex, Yinon Rudich, Thomas Boesen, Tina Šantl-Temkiv
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Microbially-produced ice nucleating proteins (INpro) are unique molecular structures with the highest known catalytic efficiency for ice formation. Airborne microorganisms utilize these proteins to enhance their survival by reducing their atmospheric
Externí odkaz:
https://doaj.org/article/085fc5d7c59d4d4abdfbcd3dd471f58b
Autor:
Steven J. Roeters, Thaddeus W. Golbek, Mikkel Bregnhøj, Taner Drace, Sarah Alamdari, Winfried Roseboom, Gertjan Kramer, Tina Šantl-Temkiv, Kai Finster, Jim Pfaendtner, Sander Woutersen, Thomas Boesen, Tobias Weidner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Ice-nucleating proteins promote ice formation at high sub-zero temperatures, but the mechanism is still unclear. The authors investigate a model ice-nucleating protein at the air-water interface using vibrational sum frequency generation spectroscopy
Externí odkaz:
https://doaj.org/article/8d49f65d10e04f0c81516b92fad4d140
Autor:
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0271145 (2022)
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenet
Externí odkaz:
https://doaj.org/article/f4644c5b4458489dba69140ec4acc22c
Autor:
Chenhui Yang, Hüsnü Aslan, Peng Zhang, Shoujun Zhu, Yong Xiao, Lixiang Chen, Nasar Khan, Thomas Boesen, Yuanlin Wang, Yang Liu, Lei Wang, Ye Sun, Yujie Feng, Flemming Besenbacher, Feng Zhao, Miao Yu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Bacterial fuel cells have generated attention with the prospect of green energy production; current research is focused on optimising the system to improve efficiency. Here, the authors report on the feeding of carbon dots to S. oneidensis MR-1 to en
Externí odkaz:
https://doaj.org/article/557662bfbd914b0f819bc9f766557ea6
Autor:
Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conforma
Externí odkaz:
https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1