Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thomas Blessing"'
Publikováno v:
Journal of Controlled Release. 91:173-181
Surface-shielded DNA delivery systems have been synthesized with virus-like characteristics that target gene expression into distant tumor tissues. Polyethylenimine (PEI)/DNA complexes ('polyplexes') conjugated with the cell-binding ligand transferri
Autor:
Guruswamy Krishnamoorthy, Thomas Blessing, Emmanuel Dauty, David Llères, Guy Duportail, Yves Mély, Jean-Pierre Clamme
Publikováno v:
Langmuir. 18:10340-10347
The stability of the complexes between DNA and nonviral vectors is a crucial parameter for efficient gene delivery into target cells. The stability must be high enough to prevent any dissociation during interaction with the plasma membrane but low en
Publikováno v:
ResearcherID
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2001, 123 (38), pp.9227-9234. ⟨10.1021/ja015867r⟩
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2001, 123 (38), pp.9227-9234. ⟨10.1021/ja015867r⟩
The size of condensed DNA particles is a key determinant for in vivo diffusion and gene delivery to cells. Gene molecules can be individually compacted by cationic thiol detergents into nanometric particles that are stabilized by oxidative conversion
Publikováno v:
Bioconjugate chemistry. 12(4)
With the aim of generating gene delivery systems for tumor targeting, we have synthesized a conjugate consisting of polyethylenimine (PEI) covalently modified with epidermal growth factor (EGF) peptides. Transfection efficiency of the conjugate was e
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 72(1-3)
Incorporation of the receptor binding ligands transferrin (Tf) or epidermal growth factor (EGF) into DNA/polyethylenimine (PEI) complexes was found to enhance gene transfer into tumor cell lines in a receptor-dependent manner. In systemic application
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 1998, 120 (33), pp.8519-8520. ⟨10.1021/ja980620o⟩
ResearcherID
Journal of the American Chemical Society, American Chemical Society, 1998, 120 (33), pp.8519-8520. ⟨10.1021/ja980620o⟩
ResearcherID
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f1c43c6d35ae1fc8ae695fb8fcece2
https://hal.archives-ouvertes.fr/hal-03261668
https://hal.archives-ouvertes.fr/hal-03261668
Publikováno v:
ResearcherID
Journal of Liposome Research
Journal of Liposome Research, Informa Healthcare, 2000, 10 (4), pp.321-327. ⟨10.3109/08982100009031102⟩
Journal of Liposome Research
Journal of Liposome Research, Informa Healthcare, 2000, 10 (4), pp.321-327. ⟨10.3109/08982100009031102⟩
International audience; Cationic lipids are efficient vectors for DNA delivery in vitro. However, they condense DNA into large polymorphic particles, which severely limits their in vivo performances due to size-restricted diffusion. In contrast, dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecf64e23c50db3f6f4df95fcb1d36b4
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166259900003&KeyUID=WOS:000166259900003
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166259900003&KeyUID=WOS:000166259900003