Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Thomas Birngruber"'
Autor:
Thomas Birngruber, Kip Vought, Simon Schwingenschuh, Peter Reisenegger, Howard Maibach, Dmitri Lissin
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2563 (2023)
Topical delivery systems (TDSs) enable the direct transport of analgesics into areas of localized pain and thus minimize the side effects of administration routes that rely on systemic drug distribution. For musculoskeletal pain, clinicians frequentl
Externí odkaz:
https://doaj.org/article/779a794117e64313aff5b38654f57c2b
Autor:
Stefania Vetrano, Gerben Bouma, Robert J. Benschop, Thomas Birngruber, Antonio Costanzo, G. R. A. M. D’Haens, Loredana Frasca, Rainer Hillenbrand, Lars Iversen, Claus Johansen, Arthur Kaser, Hans J. P. M. Koenen, Christa Noehammer, Laurent Peyrin-Biroulet, Jeroen Raes, Leonardo Ricotti, Philip Rosenstiel, Venkata P. Satagopam, Stefan Schreiber, Severine Vermeire, Andreas Wollenberg, Stephan Weidinger, Daniel Ziemek, Silvio Danese, ImmUniverse Consortium, Alessandro Armuzzi, Alessia Butera, Andrea Cafarelli, Lucia Ciglar, Ellen van den Bogaard, Elke MGJ de Jong, Ernst Dow, Marjolijn Duijvenstein, Ahmed Essaghir, Rebecca Favaro, Gionata Fiorino, Soumyabrata Ghosh, Wei Gu, Robert Häsler, Xuehui He, Roberto Lande, Judith Logmans, Christoph Magnes, Karl Nocka, Loulou Peisl, Samuel Pineda Chavez, Angela Sorriento, Klemens Vierlinger, Laurien Waaijer, Xinhui Wang, Nicolas Wisniacki, Mary Zuniga
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune mediated inflammatory diseases (IMIDs) are a heterogeneous group of debilitating, multifactorial and unrelated conditions featured by a dysregulated immune response leading to destructive chronic inflammation. The immune dysregulation can affe
Externí odkaz:
https://doaj.org/article/25c0b3e1103d4243ac5ad47318b6a393
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Topically applied drug products have experienced an extraordinary price increase in the United States, mostly due to a lack of generic products. Generic drug development is hindered by high costs and risks associated with clinical endpoint studies re
Externí odkaz:
https://doaj.org/article/98c2ac868a6f470eb6456f5aa1cbc1d5
Autor:
Thomas Altendorfer-Kroath, Joanna Hummer, Denise Kollmann, Beate Boulgaropoulos, Reingard Raml, Thomas Birngruber
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1880 (2023)
The increasing relevance of improved therapeutic monoclonal antibodies (mAbs) to treat neurodegenerative diseases has strengthened the need to reliably measure their brain pharmacokinetic (PK) profiles. The aim of this study was, therefore, to absolu
Externí odkaz:
https://doaj.org/article/3bac57ccc23743f299d97f330f2ff4f8
Autor:
Elisabeth Hofmann, Julia Fink, Anita Eberl, Eva-Maria Prugger, Dagmar Kolb, Hanna Luze, Simon Schwingenschuh, Thomas Birngruber, Christoph Magnes, Selma I. Mautner, Lars-Peter Kamolz, Petra Kotzbeck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Burn injuries initiate numerous processes such as heat shock response, inflammation and tissue regeneration. Reliable burn models are needed to elucidate the exact sequence of local events to be able to better predict when local inflammation
Externí odkaz:
https://doaj.org/article/aa79ae995bc14dc48e7d3647aad13c78
Autor:
Cornelia Pipper, Natalie Bordag, Bernadette Reiter, Kyriakos Economides, Peter Florian, Thomas Birngruber, Frank Sinner, Manfred Bodenlenz, Anita Eberl
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 758-766 (2019)
Eicosanoids are lipid-mediator molecules with key roles in inflammatory skin diseases, such as psoriasis. Eicosanoids are released close to the source of inflammation, where they elicit local pleiotropic effects and dysregulations. Monitoring inflamm
Externí odkaz:
https://doaj.org/article/15683cadfcbc49c7a16f002272bc6c20
Autor:
Roland Schaller-Ammann, Sebastian Kreß, Jürgen Feiel, Gerd Schwagerle, Joachim Priedl, Thomas Birngruber, Cornelia Kasper, Dominik Egger
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1436 (2022)
Skin equivalents and skin explants are widely used for dermal penetration studies in the pharmacological development of drugs. Environmental parameters, such as the incubation and culture conditions affect cellular responses and thus the relevance of
Externí odkaz:
https://doaj.org/article/94666c164215406ba5ea861867133d5e
Autor:
Judith C. J. Holzer-Geissler, Simon Schwingenschuh, Martin Zacharias, Johanna Einsiedler, Sonja Kainz, Peter Reisenegger, Christian Holecek, Elisabeth Hofmann, Barbara Wolff-Winiski, Hermann Fahrngruber, Thomas Birngruber, Lars-Peter Kamolz, Petra Kotzbeck
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 856 (2022)
The treatment of chronic wounds still challenges modern medicine because of these wounds’ heterogenic pathophysiology. Processes such as inflammation, ischemia and bacterial infection play major roles in the progression of a chronic wound. In recen
Externí odkaz:
https://doaj.org/article/0adb736ea2344004badd2ae3ce9c9c28
Autor:
Maximilian Kleinert, Petra Kotzbeck, Thomas Altendorfer-Kroath, Thomas Birngruber, Matthias H. Tschöp, Christoffer Clemmensen
Publikováno v:
Molecular Metabolism, Vol 13, Iss , Pp 77-82 (2018)
Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks. One prevailing theory is that impaired transport of leptin acr
Externí odkaz:
https://doaj.org/article/51632dc9d9684792b23473c688a37cb9
Autor:
Arijit Ghosh, Thomas Birngruber, Wolfgang Sattler, Thomas Kroath, Maria Ratzer, Frank Sinner, Thomas R Pieber
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98143 (2014)
Blood-brain barrier (BBB) impairment in systemic inflammation leads to neuroinflammation. Several factors including cytokines, chemokines and signal transduction molecules are implicated in BBB dysfunction in response to systemic inflammation. Here,
Externí odkaz:
https://doaj.org/article/b6d65f7b64154911be7fb61882269806