Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Thomas BRUNNER"'
Autor:
Rebekka Lambrecht, Jasmin Jansen, Franziska Rudolf, Mohamed El-Mesery, Sabrina Caporali, Ivano Amelio, Florian Stengel, Thomas Brunner
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-11 (2024)
Abstract Cell death is a fundamental process in health and disease. Emerging research shows the existence of numerous distinct cell death modalities with similar and intertwined signaling pathways, but resulting in different cellular outcomes, raisin
Externí odkaz:
https://doaj.org/article/3a9d112a7fe24ce3b7e658370f83dc81
Autor:
Alessio Butera, Lena Smirnova, Elisa Ferrando‐May, Thomas Hartung, Thomas Brunner, Marcel Leist, Ivano Amelio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-6 (2023)
Abstract Human health is determined both by genetics (G) and environment (E). This is clearly illustrated in groups of individuals who are exposed to the same environmental factor showing differential responses. A quantitative measure of the gene–e
Externí odkaz:
https://doaj.org/article/7fcae32543ce44f0b3f646c324ba17f9
Autor:
Asma Ahmed, Cindy Reinhold, Eileen Breunig, Truong San Phan, Lea Dietrich, Feodora Kostadinova, Corinne Urwyler, Verena M. Merk, Mario Noti, Israel Toja da Silva, Konstantin Bode, Fatima Nahle, Anna Pia Plazzo, Julia Koerner, Regula Stuber, Constantin Menche, Eva Karamitopoulou, Henner F. Farin, Kenneth J. Gollob, Thomas Brunner
Publikováno v:
Molecular Oncology, Vol 17, Iss 8, Pp 1545-1566 (2023)
Control of tumour development and growth by the immune system critically defines patient fate and survival. What regulates the escape of colorectal tumours from destruction by the immune system remains currently unclear. Here, we investigated the rol
Externí odkaz:
https://doaj.org/article/e2887ae1833f4172bd9bbea51ee70193
Autor:
Christian T. Wohnhaas, Kevin Baßler, Carolin K. Watson, Yang Shen, Germán G. Leparc, Cornelia Tilp, Fabian Heinemann, David Kind, Birgit Stierstorfer, Denis Delić, Thomas Brunner, Florian Gantner, Joachim L. Schultze, Coralie Viollet, Patrick Baum
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is characterized by chronic lung inflammation, tissue remodeling and emphysema. Although inflammation is critical to COPD pathogenesis, the cellular and molecular
Externí odkaz:
https://doaj.org/article/63c91076861d42e1acc8a8990681ade0
Autor:
Rebekka Lambrecht, M. Eugenia Delgado, Vincent Gloe, Karina Schuetz, Anna Pia Plazzo, Barbara Franke, Truong San Phan, Jennifer Fleming, Olga Mayans, Thomas Brunner
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113513- (2023)
Summary: The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote apoptosis resistance in various tissues and disease contexts; however, its role in liver cell death remains unexplored. Hepatocyte-specific deletion of LRH-1 cau
Externí odkaz:
https://doaj.org/article/9d1b85502e4749a7bafdf95a2fd04723
Autor:
Verena M. Merk, Truong San Phan, Alice Wiedmann, Rowan S. Hardy, Gareth G. Lavery, Thomas Brunner
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundExtra-adrenal glucocorticoid (GC) synthesis at epithelial barriers, such as skin and intestine, has been shown to be important in the local regulation of inflammation. However, the role of local GC synthesis in the lung is less well studied
Externí odkaz:
https://doaj.org/article/f2db5356f93f4035922c09efc1c98a24
Autor:
Lauren K. Wareham, Shane A. Liddelow, Sally Temple, Larry I. Benowitz, Adriana Di Polo, Cheryl Wellington, Jeffrey L. Goldberg, Zhigang He, Xin Duan, Guojun Bu, Albert A. Davis, Karthik Shekhar, Anna La Torre, David C. Chan, M. Valeria Canto-Soler, John G. Flanagan, Preeti Subramanian, Sharyn Rossi, Thomas Brunner, Diane E. Bovenkamp, David J. Calkins
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-29 (2022)
Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss em
Externí odkaz:
https://doaj.org/article/c304792ddb214075a9d068c15e1e5d12
Publikováno v:
Water Research X, Vol 17, Iss , Pp 100160- (2022)
To ensure access to safe sanitation facilities in rural communities, cheap off-grid technologies need to be developed to substitute pit latrines and open defecation. In this study, we present a prototype system based on hydrothermal oxidation, which,
Externí odkaz:
https://doaj.org/article/16dad9eb5b2a41fc84a81039e7484c1a
Autor:
Raik Schneider, Günther Gademann, Hans-Joachim Ochel, Karsten Neumann, Burkhard Jandrig, Peter Hass, Mathias Walke, Martin Schostak, Thomas Brunner, Frank Christoph
Publikováno v:
Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Background Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuximab treatment, but cli
Externí odkaz:
https://doaj.org/article/6ec71033d66d40c4ae7284bdf61dce0a
Autor:
Daniel Martin, Panagiotis Balermpas, Johannes Gollrad, Christian Weiß, Chiara Valentini, Martin Stuschke, Henning Schäfer, Christoph Henkenberens, Jürgen Debus, David Krug, Thomas Kuhnt, Thomas Brunner, Tilman Bostel, Rita Engenhart-Cabillic, Ursula Nestle, Stephanie E. Combs, Claus Belka, Matthias Hautmann, Guido Hildebrandt, Cihan Gani, Bülent Polat, Claus Rödel, Emmanouil Fokas
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 23, Iss , Pp 43-49 (2020)
Purpose: Anal squamous cell carcinomas (ASCC) are increasing in frequency across the developed world. The 3-year disease-free survival (DFS) in patients with locally-advanced disease is approximately 60% after primary radiochemotherapy (RCT). There i
Externí odkaz:
https://doaj.org/article/d3e4ec6562624439855c9fd77d25efb9