Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas B. Layton"'
Autor:
Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, Ilja M. Nolte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Dupuytren’s disease (DD) is a highly heritable fibrotic disorder of the hand with incompletely understood etiology. A number of genetic loci, including Wnt signaling members, have been previously identified. Our overall aim was to identify
Externí odkaz:
https://doaj.org/article/1f6a94e13ec342bd8fe591da7584d1c3
Autor:
Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
New anti-fibrotics aided by a better understanding of fibrotic cell subsets and their functions are needed. Here the authors perform single-cell RNA-seq and CyTOF on nodules from patients with Dupuytren’s disease to map subsets and the state of mes
Externí odkaz:
https://doaj.org/article/7e67ad4ab04e40f987c55274c1eafb3b
Autor:
Thomas B. Layton, Lynn Williams, Huw Colin-York, Fiona E. McCann, Marisa Cabrita, Marc Feldmann, Cameron Brown, Weilin Xie, Marco Fritzsche, Dominic Furniss, Jagdeep Nanchahal
Publikováno v:
Biology Open, Vol 9, Iss 3 (2020)
Mechanical force is a fundamental regulator of cell phenotype. Myofibroblasts are central mediators of fibrosis, a major unmet clinical need characterised by the deposition of excessive matrix proteins. Traction forces of myofibroblasts play a key ro
Externí odkaz:
https://doaj.org/article/d52f174eb2eb475380dde359b74ce9ac
Autor:
Thomas B. Layton, Lynn Williams, Fiona McCann, Mingjun Zhang, Marco Fritzsche, Huw Colin-York, Marisa Cabrita, Michael T. H. Ng, Marc Feldmann, Stephen N. Sansom, Dominic Furniss, Weilin Xie, Jagdeep Nanchahal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/4258103bce94430bac069c691d381403
Autor:
Thomas B. Layton
Publikováno v:
Case Reports in Otolaryngology, Vol 2017 (2017)
Squamous cell carcinoma of the temporal bone is a rare and destructive malignancy and represents both diagnostic and therapeutic challenge. The complex regional anatomy of the temporal bone requires equally intricate surgical techniques to adequately
Externí odkaz:
https://doaj.org/article/61ef0ef312fd4b61b5372820223264e9
Publikováno v:
Trends in molecular medicine.
We review the biology of Dupuytren's disease (DD), a common localised fibrotic disorder of the hand. The disease develops through a complex interplay of genetic and environmental factors, and epigenetic signalling. The early-stage disease nodules com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d61d7eeea6c30c5be7687eb41096d45
https://pubmed.ncbi.nlm.nih.gov/36566101
https://pubmed.ncbi.nlm.nih.gov/36566101
Autor:
Thomas B. Layton, Lynn Williams, Nan Yang, Mingjun Zhang, Carl Lee, Marc Feldmann, Glenda Trujillo, Dominic Furniss, Jagdeep Nanchahal
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Fibrosis is characterized by excessive matrix protein accumulation and contributes to significant morbidity and mortality in the Western world. The relative lack of effective antifibrotic therapeutics for the majority of these conditions reflects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c304c20e6222c4001a7a9f75eac7d0bc
https://doi.org/10.1073/pnas.2120336119
https://doi.org/10.1073/pnas.2120336119
Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause of morbidity and mortality and is also associated with many other disorders, including cancer and metabolic disease. In this review, we focus upon the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81eb141cf173e98ad7b1ac728c1c7c
https://ora.ox.ac.uk/objects/uuid:580e23e4-8817-48fe-87ce-5e9080162fff
https://ora.ox.ac.uk/objects/uuid:580e23e4-8817-48fe-87ce-5e9080162fff
Autor:
Dominique Davidson, Lorraine Harry, Lynn M. Williams, Chris Bainbridge, Manu Sood, Weilin Xie, Hai Fang, Bogdan Knezevic, Marisa Cabrita, Michael Sundstrӧm, Julian C. Knight, Sarah Bonham, Fiona E. McCann, Adam P. Cribbs, Roman Fischer, Jagdeep Nanchahal, Nan Yang, Leenart M Steenbeek, Thomas B. Layton, Marc Feldmann, Mingjun Zhang, David Warwick
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fibrosis remains a major unmet medical need as therapeutic targets discovered in animal models have failed to translate. A major challenge for identifying novel targets is the limited availability of early-stage human disease tissue. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d19dd786c0c58af7dc421950c39de
https://doi.org/10.1073/pnas.2004281117
https://doi.org/10.1073/pnas.2004281117
Publikováno v:
The Breast Journal. 26:1000-1003
Papillary carcinoma (PC) of the breast is a rare malignancy that accounts for 0.5%-1% of breast cancers. PC remains an understudied cancer, and we still require further information on its behaviour, staging and management. In particular, a significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff5a52f58bd6c867ddcd4918585e6f9
https://doi.org/10.1111/tbj.13746
https://doi.org/10.1111/tbj.13746