Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Thomas B. Ladd"'
Autor:
Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde, Yong Ran
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2020)
Abstract Background γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subt
Externí odkaz:
https://doaj.org/article/567da15a1da14d5dbc9b47ec7cc7ec8b
Autor:
Carole Deyts, Mary Clutter, Nicholas Pierce, Paramita Chakrabarty, Thomas B. Ladd, Anna Goddi, Awilda M. Rosario, Pedro Cruz, Kulandaivelu Vetrivel, Steven L. Wagner, Gopal Thinakaran, Todd E. Golde, Angèle T. Parent
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1345-1355.e6 (2019)
Summary: Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer’s disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived from APP are pathogenic, the APP holoprotein serves multiple purposes in the ne
Externí odkaz:
https://doaj.org/article/443b1b35e6534489a461e9115bd552bb
Autor:
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract Rare coding variants in the triggering receptor expressed on myeloid cells 2 (TREM2) are associated with increased risk for Alzheimer's disease (AD), but how they confer this risk remains uncertain. We assessed binding of TREM2, AD‐associa
Externí odkaz:
https://doaj.org/article/7dfbdafcfc1640e899512df47529113f
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204367 (2018)
Phosphorylation of the microtubule associated protein tau is an important modulator of its normal physiological functioning; however, it may also contribute to tau mis-folding and aggregation in neurodegenerative diseases, which are collectively term
Externí odkaz:
https://doaj.org/article/1e294b5fe02c4eafa57634b75e6b67ad
Autor:
Lisa M. Minter, Christian B. Lessard, Edgardo Rodriguez, Yong Ran, Thomas B. Ladd, Todd E. Golde, Barbara A. Osborne, Lucio Miele
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-8 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background γ-Secretase is a multiprotein protease that cleaves amyloid protein precursor (APP) and other type I transmembrane proteins. It has two catalytic subunits, presenilins 1 and 2 (PS1 and 2). In our previous report, we observed subtle differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4694f3231f13c43132ca64c32908c1e
http://link.springer.com/article/10.1186/s13195-020-00622-5
http://link.springer.com/article/10.1186/s13195-020-00622-5
Autor:
Pedro E. Cruz, Christopher Janus, Karen A. Scott, Marshall S. Goodwin, Melanie R. Shapiro, Brenda D. Moore, Eric G. Krause, M. Zino Kuhn, Paramita Chakrabarty, Thomas B. Ladd, Andrew Judge, Yong Ran, Todd M. Brusko, Karen N. McFarland, Annette D. de Kloet, Cara L. Croft, Todd E. Golde, Benoit I. Giasson, Daniel Ryu, Yona Levites, Hunter S. Futch, Rachel L. Nosacka
Publikováno v:
The Journal of Experimental Medicine
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe3b02ddf6c1d5f584f18b771cc69fe
http://europepmc.org/articles/PMC6829597
http://europepmc.org/articles/PMC6829597
Autor:
James C. Fleming, Thomas B. Ladd, Sixue Chen, Yohei Tanada, Todd E. Golde, Jin Koh, Fariz F. Alkassis, Hideko Kasahara, Gregory D. Bello, Lawrence X. Cai
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Cardiac contractility is enhanced by phosphorylation of myosin light chain 2 (MLC2) by cardiac-specific MLC kinase (cMLCK), located at the neck region of myosin heavy chain. In normal mouse and human hearts, the level of phosphorylation is maintained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d9a99d44fef7b6509dedc3870c6b82
http://link.springer.com/article/10.1038/s41598-019-48884-w
http://link.springer.com/article/10.1038/s41598-019-48884-w
Autor:
Karen N. McFarland, Thomas B. Ladd, Brenda D. Moore, Paramita Chakrabarty, Awilda M. Rosario, Griffin Golde, Priyanka Baloni, Mariet Allen, Todd E. Golde, Cory C. Funk, Carolina Ceballos, Max Robinson, Noa Rappaport, Nilufer Ertekin-Taner, Xue Wang
Aggregation and accumulation of amyloid-β (Aβ) is a defining feature of Alzheimer’s disease (AD) pathology. To study microglial responses to Aβ, we applied exogenous Aβ peptide, in either oligomeric or fibrillar conformation, to primary mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3e1a658a58df0dc72435a958eaa441c
https://doi.org/10.1101/2021.03.02.433544
https://doi.org/10.1101/2021.03.02.433544
Autor:
Dennis W. Dickson, Baxter Bramblett, Karen N. McFarland, Nathan D. Price, Mariet Allen, Todd E. Golde, Nilufer Ertekin-Taner, Cory C. Funk, Xue Wang, Hong-Dong Li, Xufei Liu, Max Robinson, Pedro E. Cruz, Daniel Ryu, Paramita Chakrabarty, Yona Levites, Veronica O’Neal, Thomas B. Ladd, Minerva M. Carrasquillo
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-13 (2021)
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-13 (2021)
Introduction Passive immunotherapies targeting Aβ continue to be evaluated as Alzheimer’s disease (AD) therapeutics, but there remains debate over the mechanisms by which these immunotherapies work. Besides the amount of preexisting Aβ deposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca48d705790bc7992dd7baad798eae5
https://pubmed.ncbi.nlm.nih.gov/33957936
https://pubmed.ncbi.nlm.nih.gov/33957936
Autor:
Carolina Ceballos-Diaz, Thomas B. Ladd, Giancarlo Tejeda, Brenda D. Moore, Corey Moran, Cara L. Croft, Pedro E. Cruz, Todd E. Golde, Marc Marrero, Xuefei Liu, Daniel Ryu
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d65a056a056adbef9122d1992354807
https://doi.org/10.1002/alz.043570
https://doi.org/10.1002/alz.043570