Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Thomas B. Knudsen"'
Autor:
Jocylin D. Pierro, Bhavesh K. Ahir, Nancy C. Baker, Nicole C. Kleinstreuer, Menghang Xia, Thomas B. Knudsen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors during pregnancy, leading to fetal skeleton defects. Adverse Outcome Pathway (AOP) frameworks for AT
Externí odkaz:
https://doaj.org/article/fea4d4e314784441ac0b51c30c4f7898
Autor:
Aldert H. Piersma, Nancy C. Baker, George P. Daston, Burkhard Flick, Michio Fujiwara, Thomas B. Knudsen, Horst Spielmann, Noriyuki Suzuki, Katya Tsaioun, Hajime Kojima
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100074- (2022)
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity
Externí odkaz:
https://doaj.org/article/0e3fcdf035aa43749c37ad3ba069d7ff
Autor:
Thomas B. Knudsen, Mathieu Vinken
Publikováno v:
Current Research in Toxicology, Vol 1, Iss , Pp iv- (2020)
Externí odkaz:
https://doaj.org/article/2a6aa0c25c954dc7b9317499b6fa9b76
Autor:
Madhumita Basu, Kembra L. Howdeshell, Sonja A. Rasmussen, Kristal A. Rychlik, Thomas B. Knudsen, Dana L. Shuey, William Slikker
Publikováno v:
Birth Defects Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fba3baff970ed003d9c2446e6bbc565d
https://doi.org/10.1002/bdr2.2186
https://doi.org/10.1002/bdr2.2186
Publikováno v:
Curr Opin Toxicol
New approach methodologies (NAMs) refer to any non-animal technology, methodology, approach, or combination thereof that can be used to provide information on chemical hazard and risk assessment that avoids the use of intact animals. A spectrum of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2eb184d6ef8182d57e50feeef513491f
https://pubmed.ncbi.nlm.nih.gov/36561131
https://pubmed.ncbi.nlm.nih.gov/36561131
Autor:
Anne H. Chappelle, Kimberly W. White, Donna L. Mendrick, Linda S. Birnbaum, Laurie C. Haws, Suzanne Fitzpatrick, K. Nadira De Abrew, Katerine S. Saili, Jill A Franzosa, Thomas B. Knudsen, Susan Y. Euling, Alison Elder, George P. Daston, Nicole Kleinstreuer, Alexandra Turley, Ruthann A. Rudel, Dana C. Dolinoy, Elaine M. Faustman, Germaine M. Buck Louis, Thaddeus T. Schug, Todd J. Zurlinden, Robyn L Tanguay, Barbara A. Wetmore, Derik E. Haggard, Kristi Pullen Fedinick
Publikováno v:
Toxicol Sci
FutureTox IV, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2018. Building upon FutureTox I, II, and III, this conference focused on the latest science and technology for in vitro profiling and in silico m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310085fc00705890b8369a9c0dbe4576
https://doi.org/10.1093/toxsci/kfab013
https://doi.org/10.1093/toxsci/kfab013
Publikováno v:
Birth Defects Res
Birth Defects Research
Birth Defects Research
Cellular analysis of developmental processes and toxicities has traditionally entailed bulk methods (e.g., transcriptomics) that lack single cell resolution or tissue localization methods (e.g., immunostaining) that allow only a few genes to be monit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f6e68cbcc5bfbc329b4ef1221b3996
https://doi.org/10.1002/bdr2.1870
https://doi.org/10.1002/bdr2.1870
Publikováno v:
Reproductive Toxicology. 99:109-130
All-trans retinoic acid (ATRA), the biologically active form of vitamin A, is instrumental in regulating the patterning and specification of the vertebrate embryo. Various animal models demonstrate adverse developmental phenotypes following experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c5f9483065fefe3298384c28c60b01
https://doi.org/10.1016/j.reprotox.2020.10.014
https://doi.org/10.1016/j.reprotox.2020.10.014
Autor:
Harm J. Heusinkveld, Aldert H. Piersma, Yvonne C.M. Staal, George P. Daston, Nancy C. Baker, Thomas B. Knudsen
Publikováno v:
Reprod Toxicol
In recent years, the development and implementation of animal-free approaches to chemical and pharmaceutical hazard and risk assessment has taken off. Alternative approaches are being developed starting from the perspective of human biology and physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0886594f2bf68c12ec84bd1488235b3
https://doi.org/10.1016/j.reprotox.2020.09.002
https://doi.org/10.1016/j.reprotox.2020.09.002
Autor:
Xiaoqing Chang, Jessica Palmer, Annie Lumen, Un Jung Lee, Patricia Ceger, Kamel Mansouri, Catherine Sprankle, Elizabeth Donley, Shannon Bell, Thomas B. Knudsen, John Wambaugh, Bethany Cook, David Allen, Nicole Kleinstreuer
Publikováno v:
Birth defects researchREFERENCES. 114(16)
The developmental toxicity potential (dTP) concentration from the devTOX quickPredict (devTOXVPA and a series of structural analogues were tested with the devTOXThe EAD estimates for the VPA analogues based on different PK/PBPK models were quantitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a74ff90df4ed6d02beb030e8b7fee50
https://pubmed.ncbi.nlm.nih.gov/35532929
https://pubmed.ncbi.nlm.nih.gov/35532929