Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas B Stoker"'
Autor:
Thomas B Stoker, Roger A Barker
Publikováno v:
F1000Research, Vol 9 (2020)
Parkinson’s disease (PD) is a common neurodegenerative disease typified by a movement disorder consisting of bradykinesia, rest tremor, rigidity, and postural instability. Treatment options for PD are limited, with most of the current approaches ba
Externí odkaz:
https://doaj.org/article/d0c8cdf3318f4638bf01f79093da20a5
Publikováno v:
Neural Regeneration Research, Vol 12, Iss 3, Pp 389-392 (2017)
Parkinson's disease (PD) is a neurodegenerative condition which causes a characteristic movement disorder secondary to loss of dopaminergic neurons in the substanitia nigra. The motor disorder responds well to dopamine-replacement therapies, though t
Externí odkaz:
https://doaj.org/article/61e39f2a773946d194f53ee97beb0956
Autor:
Sarah L Mason, Julia C. Greenland, Thomas B Stoker, Helen Santini, Simon Holden, Roger A. Barker
Publikováno v:
Practical Neurology. 22:32-41
Huntington’s disease (HD) is an inherited neurodegenerative disease characterised by neuropsychiatric symptoms, a movement disorder (most commonly choreiform) and progressive cognitive impairment. The diagnosis is usually confirmed through identifi
Publikováno v:
Journal of Neurology. 268:3916-3919
Autor:
Thomas B Stoker
Publikováno v:
Practical Neurology. :pn-2022
Autor:
Romina Vuono, Marcella Birtele, Janelle Drouin-Ouellet, Petter Storm, Fredrik Nilsson, Roger A. Barker, Yogita Sharma, Shelby Shrigley, Malin Parmar, Maria Pereira, Thomas B Stoker, Emilie M. Legault, Karolina Pircs, Johan Jakobsson
Understanding the pathophysiology of Parkinson’s disease has been hampered by the lack of models that recapitulate all the critical factors underlying its development. Here, we generated functional induced dopaminergic neurons (iDANs) that were dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302821c5210820579a5202cdd78459e0
https://doi.org/10.1101/2021.04.23.441070
https://doi.org/10.1101/2021.04.23.441070
Autor:
K.C Sharma, Horváth, Sébastien S. Hébert, Malin Parmar, György Marko-Varga, Lagerwall J, Bob A. Hersbach, Janelle Drouin-Ouellet, Roger A. Barker, Petter Storm, Patrik Johansson, Jeovanis Gil, Romina Vuono, Kenneth D. M. Harris, Melinda Rezeli, Daniela A. Grassi, Yogita Sharma, Karolina Pircs, Marie E. Jönsson, Isabelle St-Amour, Lagerström S, Johan Jakobsson, Thomas B Stoker, Raquel Garza
Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD has remained challenging, as rodent and cellular models poorly recapitulate the disease. To address this, we generated ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e319f860465633ac18adccdda66bad1
https://doi.org/10.1101/2021.03.01.433433
https://doi.org/10.1101/2021.03.01.433433
Autor:
Jonathan Evans, Marta Camacho, David P. Breen, Ganqiang Liu, Roger A. Barker, Clemens R. Scherzer, Thomas B Stoker, Caroline H. Williams-Gray, Thomas Foltynie, Sophie Winder-Rhodes
Publikováno v:
Stoker, T B, Camacho, M, Winder-rhodes, S, Liu, G, Scherzer, C R, Foltynie, T, Evans, J, Breen, D P, Barker, R A & Williams-gray, C H 2020, ' Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease ', Journal of Neurology, Neurosurgery & Psychiatry, pp. jnnp-2020-322857 . https://doi.org/10.1136/jnnp-2020-322857
IntroductionVariants in the GBA1 gene have been identified as a common risk factor for Parkinson’s disease (PD). In addition to pathogenic mutations (those associated with Gaucher disease), a number of ‘non-pathogenic’ variants also occur at in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b940034c39ab46a2c91fbde7f7eb8984
https://hdl.handle.net/20.500.11820/f79834da-ee46-4aa5-b268-f2053dbcb7ad
https://hdl.handle.net/20.500.11820/f79834da-ee46-4aa5-b268-f2053dbcb7ad
Autor:
Roger A. Barker, Thomas B Stoker
Publikováno v:
BioDrugs. 32:357-366
Parkinson's disease is the second most common neurodegenerative disorder. It is characterised by a typical movement disorder that occurs in part because of the selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta.
Publikováno v:
Movement Disorders
Huntington’s disease (HD) is a genetic disorder caused by an expanded CAG repeat in the huntingtin gene, and although there are currently no disease-modifying treatments, there is much excitement about the prospect of treatments targeting huntingti