Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas B Stanley"'
Autor:
Ying Fu, Juliana da Fonseca Rezende E Mello, Bryan D Fleming, Alex Renn, Catherine Z Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T Eastman, Zina Itkin, Thomas B Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D Hall, Mario J Borgnia, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272364 (2022)
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://doaj.org/article/f2f1ebb6cd9a4991a32d3546fa2987d7
Autor:
Rakesh Kumar, Jeffrey M. Axten, Beat M. Jucker, Hasan Alsaid, Anthony E. Choudhry, Nathan Gaul, Aaron Goetz, Brent Sanders, Thomas B. Stanley, Katherine Moss, David J. Figueroa, Shu-Yun Zhang, Elisabeth Minthorn, Qi Liu, Charity Atkins
Supplementary Material PDF file - 147K, Supplementary Methods: Immunohistochemistry and magnetic resonance imaging. Supplementary Table 1: Kinase selectivity profiling of GSK2656157. Supplementary Table 2: Gene list for Human UPR array
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bae45c3c74dc63b99fc43eade9948d3
https://doi.org/10.1158/0008-5472.22399736
https://doi.org/10.1158/0008-5472.22399736
Autor:
Rakesh Kumar, Jeffrey M. Axten, Beat M. Jucker, Hasan Alsaid, Anthony E. Choudhry, Nathan Gaul, Aaron Goetz, Brent Sanders, Thomas B. Stanley, Katherine Moss, David J. Figueroa, Shu-Yun Zhang, Elisabeth Minthorn, Qi Liu, Charity Atkins
Supplementary Figures 1-3 PDF file - 245K, Supplementary Figure 1: Dose-dependent pharmacodynamic effect of GSK2656157 on PERK in mouse pancreas. Supplementary Figure 2: Specificity of phospho-PERK antibody in mouse cells. Supplementary Figure 3: Eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be769ac9df05c7852876b0e255be076
https://doi.org/10.1158/0008-5472.22399739
https://doi.org/10.1158/0008-5472.22399739
Autor:
Ying Fu, Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M. Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T. Eastman, Zina Itkin, Thomas B. Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D. Hall, Mario J. Borgnia, Anton Simeonov
Publikováno v:
bioRxiv
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e229c55e6f9f11419c5c35925abed82
https://doi.org/10.1101/2021.10.22.465476
https://doi.org/10.1101/2021.10.22.465476
Autor:
Scott D Sigethy, Elisabeth A. Minthorn, Jesus R. Medina, Thomas Mencken, Charity Atkins, Kirsten M. Kahler, William Hoi Hong Li, Annie M. Hassell, Xuan Hong, Stuart Paul Romeril, Aaron S. Goetz, Ginger H. Tomberlin, Qi Liu, Dirk A. Heerding, Lisa M. Shewchuk, Robert T. Gampe, Sridhar K. Rabindran, Arthur Shu, Rakesh Kumar, Jeffrey M. Axten, Thomas B. Stanley, Yanhong Feng, Seth W. Grant, J. David Taylor
Publikováno v:
Journal of Medicinal Chemistry. 55:7193-7207
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0a943caa745acd6dbec2dad8aa8849
https://doi.org/10.1021/jm300713s
https://doi.org/10.1021/jm300713s
Autor:
Adam Ashe, Thomas B. Stanley, Todd W Shearer, Craig D. Wagner, John C. Ulrich, Lisa M. Leesnitzer, Barry G. Shearer, Raymond V. Merrihew, Robert W. Wiethe, James M. Way, Robert X. Xu, Andrew N. Billin, Timothy M. Willson, Michael R. Jeune
Publikováno v:
Journal of Medicinal Chemistry. 53:1857-1861
4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPARdelta with good pharmacokinetic properties. A detailed binding study using mass spectral analysis confirmed cova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8984378fd8ba14814739549a07608292
https://doi.org/10.1021/jm900464j
https://doi.org/10.1021/jm900464j
Autor:
Thomas B. Stanley, A. Calvert, J. Stuart Elborn, Jonathan Stirling, John E. Moore, Colin E. Goldsmith, Yasunori Maeda, Mark J.D. Griffiths, Jacqueline C. Rendall, Anne Loughrey, Paul J. Rooney, B. Cherie Millar
Publikováno v:
Zoonoses and Public Health. 57:e47-e53
A microbiological study was undertaken to assess the risk of infection to a CF patient from a collection of pet reptiles, particularly atypical mycobacteria. This study helped to verify that the reptiles under the care of the CF patient did not harbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4137dad32af8aabaefe459d804dae53b
https://doi.org/10.1111/j.1863-2378.2009.01293.x
https://doi.org/10.1111/j.1863-2378.2009.01293.x
Autor:
Eugene T. Grygielko, Eugene L. Stewart, Jeffrey D. Bray, Nicholas J. Laping, Charlene Wu, Shawn P. Williams, Thomas B. Stanley, Kevin P. Madauss, Su-Jun Deng, Steve A. Short, Anthony Sulpizio, Scott K. Thompson
Publikováno v:
Molecular Endocrinology. 21:1066-1081
Selective progesterone receptor modulators (SPRMs) have been suggested as therapeutic agents for treatment of gynecological disorders. One such SPRM, asoprisnil, was recently in clinical trials for treatment of uterine fibroids and endometriosis. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c51747593a2c6b0898680d9bb76c25
https://doi.org/10.1210/me.2006-0524
https://doi.org/10.1210/me.2006-0524
Autor:
Gang An, Rebecca I. Kalman, Eugene L. Stewart, Bin He, Elizabeth M. Wilson, Robert T. Gampe, Adam J. Kole, John T. Minges, Thomas B. Stanley, Andrew T. Hnat
Publikováno v:
Molecular Cell. 16:425-438
The androgen receptor (AR) is required for male sex development and contributes to prostate cancer cell survival. In contrast to other nuclear receptors that bind the L XX LL motifs of coactivators, the AR ligand binding domain is preferentially enga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d13edfc45a143e9ade557c8431ebd40
https://doi.org/10.1016/j.molcel.2004.09.036
https://doi.org/10.1016/j.molcel.2004.09.036
Autor:
Julie B. Stimmel, H. Eric Xu, Valerie G. Montana, Linda B. Moore, Millard H. Lambert, Steven G. Blanchard, Thomas B. Stanley, Cristin M. Galardi, Jason A. Holt, Lisa M. Leesnitzer
Publikováno v:
Biochemistry. 42:9278-9287
Natural ligands for nuclear receptors are believed to activate gene transcription by causing dissociation of corepressors and promoting the association of coactivator proteins. Using multiple biophysical techniques, we find that peptides derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dc6c119ee683c0d41ba7ac9bbcc68a
https://doi.org/10.1021/bi034472c
https://doi.org/10.1021/bi034472c