Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas B Nicholson"'
Autor:
Thomas B Nicholson, Anup K Singh, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Margaret Goetschkes, Paola Capodieci, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60913 (2013)
Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins
Externí odkaz:
https://doaj.org/article/9e1f88af16364c7b858f1fedc06057a6
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Jayson Chen, Mateusz Piksa, Giorgio G. Galli, Smita Jaiswal, Keith Mansfield, Viviana Cremasco, Sinan Isim, Thomas B. Nicholson, Angelo Grauel, Ana Carrion, Stephanie Schwartz, Bernd Voedisch, Emily Lee, Joyce Judge, Michelle Steinkrauss, Andrew Anh Nguyen, Sarah Szvetecz, Chietara Japutra, Lingheswar Sadhasivam, Nicole Vincent Jordan, Brian Granda, Jinsheng Liang, Hong Lei, Hui Qin Wang, Dana B. Walker, Yiqin Wang, Joel Wagner, Qing Fang, Rie Maeda, Quincey Simmons, Ryan Polli
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
High-grade serous ovarian cancers (HGSOC) represent the most common subtype of ovarian malignancies. Due to the frequency of late-stage diagnosis and high rates of recurrence following standard of care treatments, novel therapies are needed to promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04761adfd4d1c2c533387105c642a88
https://pubmed.ncbi.nlm.nih.gov/34290299
https://pubmed.ncbi.nlm.nih.gov/34290299
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature communications. 13(1)
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. Here, we identified the cell adhesion molecule KIRREL1 as an upstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44427e821727c484783475c7e3846fa
https://pubmed.ncbi.nlm.nih.gov/35177623
https://pubmed.ncbi.nlm.nih.gov/35177623
Autor:
Barrett Leehy, Hong Lei, Jeffrey M. Lynch, Veronica Saenz-Vash, Chuanxi Xiang, Parvaneh Katoli, Ganesh Prasanna, Erik Meredith, Bing Li, Dennis S Rice, Amy Chen, Y. Karen Wang, Thomas B. Nicholson, Nalini Rangaswamy
Publikováno v:
Journal of Biological Chemistry. 293:20137-20156
Myocilin (MYOC) was discovered more than 20 years ago and is the gene whose mutations are most commonly observed in individuals with glaucoma. Despite extensive research efforts, the function of WT MYOC has remained elusive, and how mutant MYOC is li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae3826f777c3f3a0f945d85cd54ed32
https://doi.org/10.1074/jbc.ra118.004325
https://doi.org/10.1074/jbc.ra118.004325
Autor:
Megan Fitzgerald, lingling Yang, Karena Yan, Kazuo Imaizumi, David S. Uygun, Soon-Wook Choi, David Baez-Nieto, Jen Q. Pan, Zhanyan Fu, Xiaohong Mao, Mario A. Arias-Garcia, Shaun Purcell, Thomas B. Nicholson, Andrew S. Allen, Guoping Feng, Jen M. Hope, James M. McNally, Qiangge Zhang, Ritchie E. Brown, Ayan Ghoshal, Robert E. Strecker, Violeta G. Lopez-Huerta
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-12 (2020)
CACNA1I, a schizophrenia risk gene, encodes a subtype of voltage-gated T-type calcium channel CaV3.3. We previously reported that a patient-derived missense de novo mutation (R1346H) of CACNA1I impaired CaV3.3 channel function. Here, we generated CaV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cec1ab0bbb6a46c5bfe1e8fca4a51d0e
https://doi.org/10.1038/s41398-020-0685-1
https://doi.org/10.1038/s41398-020-0685-1
Autor:
Katsuya Nagaoka, Mitsuyoshi Nakao, Ryuta Takase, Taiping Chen, Akihisa Sakamoto, Hirotaka Araki, Thomas B. Nicholson, Shinjiro Hino, Kotaro Anan, Yuko Hino, Kensaku Kohrogi
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(4)
Transcriptional and epigenetic regulation is fundamentally involved in initiating and maintaining progression of cellular differentiation. The 2 types of thermogenic adipocytes, brown and beige, are thought to be of different origins but share functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111b932aee0cb7d82ca4a5a8874746ff
https://pubmed.ncbi.nlm.nih.gov/30681884
https://pubmed.ncbi.nlm.nih.gov/30681884
Autor:
Sara Calabretta, Stéphane Richard, Lama Darbelli, Thomas B. Nicholson, Gillian Vogel, Zhenbao Yu, Claudia L. Kleinman, Karine Choquet
SummaryPlatelet derived growth factor receptor α (PDGFRα) signaling is required for proliferation, commitment and maintenance of oligodendrocyte (OL) precursor cells (OPCs). PDGFRα signaling promotes OPC homeostasis and its attenuation signals OPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91732e93e6efd2dd1c1c30a6930539d
https://doi.org/10.1101/252056
https://doi.org/10.1101/252056
Autor:
Stephen B. Helliwell, Ayako Honda, Jane Nagel, Xiaohong Mao, Debra Burdick, Julie Bastien, Henry Wang, Suchithra Menon, Hong Lei, Robert Elling, William E. Dowdle, Dirksen E. Bussiere, Mary Ellen Digan, Lawrence G. Hamann, Ivan Cornella-Taracido, Beat Nyfeler, David Schwalb, Dmitri Wiederschain, Savuth Ugwonali, Fred Harbinski, Markus Schirle, Peter Fekkes, Christine D. Wilson, Shanming Liu, Thomas B. Nicholson, Edmund Harrington, Jason R. Thomas, Reginald Valdez, Vic E. Myer, Brendan D. Manning, Erin P. Keaney, John A. Tallarico, Peter Finan, Mark Labow, Gwynn Pardee, Simon D’Aquin, Andrew F. Powers, John Cantwell, Philip Bergman, Qing Fang, Leon Murphy, Zuncai Wang, Mark Knapp, Jenny Kuerth, Ellen Triantafellow, Catherine Luu, Jeffery A. Porter
Publikováno v:
Nature Cell Biology. 16:1069-1079
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2f917aae57e431c829762b739d3143
https://doi.org/10.1038/ncb3053
https://doi.org/10.1038/ncb3053
Autor:
Florian Nigsch, Lapo Morelli, Zinger Yang, Tianliang Sun, Maryam Syed, Linda E. Greenbaum, Guglielmo Roma, John S. Reece-Hoyes, Jan S. Tchorz, Luigi Terracciano, Thomas B. Nicholson, Andreas W. Sailer, Caroline Gubser Keller, Lara Planas-Paz, Nadire Cochran, Sven Schuierer, Tewis Bouwmeester, Yi Yang, Carlos M. Cobos, Jesse J. Lugus, Annick Waldt, Vanessa Orsini, John Alford, Jasna Jetzer, Xiaohong Mao, Philipp S. Hoppe, Frederic Sigoillot, Wibke Schwarzer, Monika Pikiolek, Nicole Carballido-Perrig, Gregory McAllister, Carsten Russ, Feng Cong, Sebastian Bergling, Le Zhang, Gregory R. Hoffman, Marilisa Neri, Rachel Cuttat, Bernd Kinzel
Publikováno v:
Cell Stem Cell. 25:39-53.e10
Summary Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells that establish a ductular reaction (DR) to support liver regeneration following injury. Liver damage induces periportal LGR5+ putative liver ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c519d621902b0b14ea237b397fc47a88
https://doi.org/10.1016/j.stem.2019.04.005
https://doi.org/10.1016/j.stem.2019.04.005