Výsledky vyhledávání - "Thomas Arnhold"

An integrated platform for fully automated high-throughput LC–MS/MS analysis of in vitro metabolic stability assay samples

Autor: Thomas Arnhold, Roderich D. Süssmuth, Andreas H. Luippold, Wolfgang Jörg

Publikováno v: International Journal of Mass Spectrometry. 296:1-9

The evaluation of ADME properties contributes importantly to drug candidate selection and therefore is crucial for the drug discovery process. Providing a sufficiently high-throughput capability in laboratories dedicated to early pharmacokinetic stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::489e6a9d1c850c5c6d3f4fd1f9881122
https://doi.org/10.1016/j.ijms.2010.07.004

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First-in-human phase I trial of BI 836880, a vascular endothelial growth factor (VEGF)/angiopoietin-2 (Ang-2)-blocking nanobody, given every 3 weeks (q3w) in patients (pts) with advanced/metastatic solid tumors

Autor: Thomas Arnhold, Dooti Roy, Christophe Le Tourneau, Francesco Ricci, Christoph Rummelt, O. Fietz, Rainer Claus, Ralph Fritsch, Zohra Oum'Hamed, Björn Hackanson

Publikováno v: Journal of Clinical Oncology. 36:12024-12024

12024Background: VEGF and Ang-2 inhibitors have demonstrated clinical activity in various tumor types. Given the overlap of the VEGF/VEGFR2 and Ang-2/Tie-2 signaling pathways there is a rationale f...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e8dda42978b7086abe9f20d178495a4
https://doi.org/10.1200/jco.2018.36.15_suppl.12024

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PK/PD properties of BI 836880, a vascular endothelial growth factor (VEGF)/angiopoietin-2 (Ang-2)-blocking nanobody, in patients (pts) with advanced/metastatic solid tumors

Autor: Ralph Fritsch, Björn Hackanson, Heiko G. Niessen, Thomas Arnhold, Christophe Le Tourneau, Rainer Claus, Francesco Ricci, Ulrich Kunz, Elena Elez, Ralph Graeser, Josep Tabernero, Sascha Keller, Nicolas Isambert

Publikováno v: Journal of Clinical Oncology. 36:2523-2523

2523Background: BI 836880 (q3w or qw, iv) was evaluated in two first-in-human, Phase I trials in pts with advanced/metastatic solid tumors. We report exploratory PK/PD analysis of these studies to ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d0138aa5acbfd6308eb1cab303f6787
https://doi.org/10.1200/jco.2018.36.15_suppl.2523

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Multivariate modeling of cytochrome P450 3A4 inhibition

Autor: Jan M. Kriegl, Lennart Eriksson, Thomas Arnhold, Bernd Beck, Thomas R. Fox, Erik Johansson

Publikováno v: European Journal of Pharmaceutical Sciences. 24:451-463

In the early phases of current pharmaceutical research projects, huge numbers of compounds are tested on their biological activity with respect to a certain target by experimental or virtual screening campaigns. To reduce the attrition rate in later

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db1df600a27ea1f1184889109725089
https://doi.org/10.1016/j.ejps.2004.12.009

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A support vector machine approach to classify human cytochrome P450 3A4 inhibitors

Autor: Jan M. Kriegl, Bernd Beck, Thomas Arnhold, Thomas R. Fox

Publikováno v: Journal of Computer-Aided Molecular Design. 19:189-201

The cytochrome P450 (CYP) enzyme superfamily plays a major role in the metabolism of commercially available drugs. Inhibition of these enzymes by a drug may result in a plasma level increase of another drug, thus leading to unwanted drug-drug interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc566e311709dfb09212df6e97c36fb
https://doi.org/10.1007/s10822-005-3785-3

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Elektronická kniha

Sprechwissenschaft & Psycholinguistik 5 : Beiträge aus Forschung und Praxis

Autor: Gerd Kegel, Thomas Arnhold, Klaus Dahlmeier, Gerhard Schmid, Bernd Tischer

In der Reihe'Sprechwissenschaft & Psycholinguistik'werden aktuelle Beiträge zur Erforschung von Sprachprozessen publiziert.Einen Schwerpunkt des fünften Bandes bildet das Thema'Dysgrammatismus'. Weitere Forschungsbeiträge beziehen sich auf die The

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Porcine Intestinal Metabolism of Excess Vitamin A Differs Following Vitamin A Supplementation and Liver Consumption

Autor: Heinz Nau, Thomas Arnhold, Alfonso Lampen, Silke Meyer, Hermann J. Rothkoetter

Publikováno v: The Journal of Nutrition. 132:197-203

Vitamin A is a well-established teratogen in all animal species. A number of case reports also suggest a teratogenic potential of vitamin A in humans. A possible teratogenic risk of dietary liver vitamin A intake, the kinetics of vitamin A and its me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7554904cd55e6c315e3adb1a9be491d5
https://doi.org/10.1093/jn/132.2.197

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Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry

Autor: Thomas Arnhold, Andreas H. Luippold, Roderich D. Süssmuth, Wolfgang Jörg, Beate Krüger

Publikováno v: Journal of biomolecular screening. 16(3)

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236c9226ba477210c01a186bb36adfbe
https://pubmed.ncbi.nlm.nih.gov/21335598

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Prevention of vitamin A teratogenesis by phytol or phytanic acid results from reduced metabolism of retinol to the teratogenic metabolite, all-trans-retinoic acid

Autor: Thomas Arnhold, Mohamed M. Elmazar, Heinz Nau

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 66(2)

Previous studies in our laboratory showed a synergistic interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in regard to teratogenic effects produced in mice (M. M. Elmazar et al., 2001, TOXICOL: Appl. Pharmacol. 170, 2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6ee05e353ea7bdb09ea9c2b51d091c
https://pubmed.ncbi.nlm.nih.gov/11896294

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