Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Thomas A. Weston"'
Autor:
Paul H. Kim, Natalie Y. Chen, Patrick J. Heizer, Yiping Tu, Thomas A. Weston, Jared L.-C. Fong, Navjot Kaur Gill, Amy C. Rowat, Stephen G. Young, Loren G. Fong
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The mutant nuclear lamin protein (progerin) produced in Hutchinson-Gilford progeria syndrome (HGPS) results in loss of arterial smooth muscle cells (SMCs), but the mechanism has been unclear. We found that progerin induces repetitive nuclear membrane
Externí odkaz:
https://doaj.org/article/782e92b7c80f4e82b3a9551cf8e5b14f
Autor:
Sophie Nguyen, Kristi Baker, Benjamin S. Padman, Ruzeen Patwa, Rhys A. Dunstan, Thomas A. Weston, Kyle Schlosser, Barbara Bailey, Trevor Lithgow, Michael Lazarou, Antoni Luque, Forest Rohwer, Richard S. Blumberg, Jeremy J. Barr
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/74cd374020494acb9eeaad6d5c0c83bd
Autor:
Sophie Nguyen, Kristi Baker, Benjamin S. Padman, Ruzeen Patwa, Rhys A. Dunstan, Thomas A. Weston, Kyle Schlosser, Barbara Bailey, Trevor Lithgow, Michael Lazarou, Antoni Luque, Forest Rohwer, Richard S. Blumberg, Jeremy J. Barr
Publikováno v:
mBio, Vol 8, Iss 6 (2017)
ABSTRACT Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs. However, th
Externí odkaz:
https://doaj.org/article/65339f7f744a4fe48aedd452b60951cc
Autor:
Xu Xiao, John Paul Kennelly, Alessandra Ferrari, Bethan L. Clifford, Emily Whang, Yajing Gao, Kevin Qian, Jaspreet Sandhu, Kelsey E. Jarrett, Madelaine C. Brearley-Sholto, Alexander Nguyen, Rohith T. Nagari, Min Sub Lee, Sicheng Zhang, Thomas A. Weston, Stephen G. Young, Steven J. Bensinger, Claudio J. Villanueva, Thomas Q. de Aguiar Vallim, Peter Tontonoz
Publikováno v:
Nature Metabolism. 5:165-181
Autor:
Kevin Qian, Marcus J. Tol, Jin Wu, Lauren F. Uchiyama, Xu Xiao, Liujuan Cui, Alexander H. Bedard, Thomas A. Weston, Pradeep S. Rajendran, Laurent Vergnes, Yuta Shimanaka, Yesheng Yin, Yasaman Jami-Alahmadi, Whitaker Cohn, Bryce T. Bajar, Chia-Ho Lin, Benita Jin, Laura A. DeNardo, Douglas L. Black, Julian P. Whitelegge, James A. Wohlschlegel, Karen Reue, Kalyanam Shivkumar, Feng-Jung Chen, Stephen G. Young, Peng Li, Peter Tontonoz
Publikováno v:
Nature
Multilocular adipocytes are a hallmark of thermogenic adipose tissue(1,2), but the factors that enforce this cellular phenotype are largely unknown. Here, we show that an adipocyte-selective product of the Clstn3 locus (CLSTN3β) present in only plac
Autor:
Xuchen Hu, Thomas A Weston, Cuiwen He, Rachel S Jung, Patrick J Heizer, Brian D Young, Yiping Tu, Peter Tontonoz, James A Wohlschlegel, Haibo Jiang, Stephen G Young, Loren G Fong
Publikováno v:
eLife, Vol 8 (2019)
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction
Externí odkaz:
https://doaj.org/article/c8058d365a7d44e2aede24f03b4dacae
Autor:
Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
Publikováno v:
eLife, Vol 8 (2019)
GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoprotei
Externí odkaz:
https://doaj.org/article/c9e3de5bd1f74f16b0b5035d702b97d3
Autor:
Wenxin Song, Ye Yang, Patrick Heizer, Yiping Tu, Thomas A. Weston, Joonyoung R. Kim, Priscilla Munguia, Hyesoo Jung, Jared L.-C. Fong, Caitlyn Tran, Michael Ploug, Anne P. Beigneux, Stephen G. Young, Loren G. Fong
Publikováno v:
Song, W, Yang, Y, Heizer, P, Tu, Y, Weston, T A, Kim, J R, Munguia, P, Jung, H, Fong, J L C, Tran, C, Ploug, M, Beigneux, A P, Young, S G & Fong, L G 2023, ' Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 8, e2219833120 . https://doi.org/10.1073/pnas.2219833120
Lipoprotein lipase (LPL) is secreted into the interstitial spaces by parenchymal cells and then transported into capillaries by GPIHBP1. LPL carries out the lipolytic processing of triglyceride (TG)-rich lipoproteins (TRLs), but the tissue-specific r
Autor:
Punit P. Seth, Haibo Jiang, Stephen G. Young, K. Swaminathan Iyer, Paul Guagliardo, Cuiwen He, Kai Chen, Thomas A. Weston, Loren G. Fong, Michael T. Migawa, C. Frank Bennett, Wenxin Song, Michael Tanowitz
Publikováno v:
Nucleic Acids Research
Nucleic acid therapeutics (NATs) have proven useful in promoting the degradation of specific transcripts, modifying gene expression, and regulating mRNA splicing. In each situation, efficient delivery of nucleic acids to cells, tissues and intracellu
Autor:
Rong Mu, Andrew S Cutting, Yvette Del Rosario, Nicholas Villarino, Lara Stewart, Thomas A Weston, Kathryn A Patras, Kelly S Doran
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153891 (2016)
Group B Streptococcus (GBS) is a major causative agent of neonatal meningitis due to its ability to efficiently cross the blood-brain barrier (BBB) and enter the central nervous system (CNS). It has been demonstrated that GBS can invade human brain m
Externí odkaz:
https://doaj.org/article/eab5e5b3bbce43729217d5d8c8efb39d