Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Thomas A. Waigh"'
Autor:
Conor M. Lewis, Charles T. Heise, Natalia Harasimiuk, Jennifer Tovey, Jian R. Lu, Thomas A. Waigh
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026105-026105-8 (2024)
The viscoelasticity of monoclonal antibodies (mAbs) is important during their production, formulation, and drug delivery. High concentration mAbs can provide higher efficacy therapeutics (e.g., during immunotherapy) and improved efficiency during the
Externí odkaz:
https://doaj.org/article/3f9f7e7dde6947139450411208214f3a
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The endoplasmic reticulum (ER) is a eukaryotic subcellular organelle composed of tubules and sheet-like areas of membrane connected at junctions. The tubule network is highly dynamic and undergoes rapid and continual rearrangement. There are
Externí odkaz:
https://doaj.org/article/83e6f201f1ce47c7bd622bccb6d53b58
Autor:
Julia Y. Rho, Henry Cox, Edward D. H. Mansfield, Sean H. Ellacott, Raoul Peltier, Johannes C. Brendel, Matthias Hartlieb, Thomas A. Waigh, Sébastien Perrier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Reversibility of peptide hydrogen bonded supramolecular assemblies makes them tunable but highly dynamic and prone to disassembly at the low concentration. Here the authors show a secondary hydrophobic interaction, near the peptide core that stabilis
Externí odkaz:
https://doaj.org/article/0f279d02fc7b4f9182815ea5ac0d8278
Autor:
Meng Wang, Jiqian Wang, Peng Zhou, Jing Deng, Yurong Zhao, Yawei Sun, Wei Yang, Dong Wang, Zongyi Li, Xuzhi Hu, Stephen M. King, Sarah E. Rogers, Henry Cox, Thomas A. Waigh, Jun Yang, Jian Ren Lu, Hai Xu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Peptide self-assembly is a hierarchical process which includes forming β-sheets but the formation of high ordered structures remains largely unexplored. Here the authors report on a super-secondary structural template, based on well-defined hydrogen
Externí odkaz:
https://doaj.org/article/ab751f3bb7214319b08456ee2c3baa73
Autor:
Pantelis Georgiades, Victoria J. Allan, Graham D. Wright, Philip G. Woodman, Parinya Udommai, Manloeng A. Chung, Thomas A. Waigh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The endoplasmic reticulum (ER) is a single organelle in eukaryotic cells that extends throughout the cell and is involved in a large number of cellular functions. Using a combination of fixed and live cells (human MRC5 lung cells) in diffrac
Externí odkaz:
https://doaj.org/article/bc9000eb178b46f8b13849ab3ee4c145
Autor:
Daniel Han, Nickolay Korabel, Runze Chen, Mark Johnston, Anna Gavrilova, Victoria J Allan, Sergei Fedotov, Thomas A Waigh
Publikováno v:
eLife, Vol 9 (2020)
Intracellular transport is predominantly heterogeneous in both time and space, exhibiting varying non-Brownian behavior. Characterization of this movement through averaging methods over an ensemble of trajectories or over the course of a single traje
Externí odkaz:
https://doaj.org/article/980c7e3f76b6436895aaad43ac9d0b64
Autor:
Nickolay Korabel, Daniel Han, Alessandro Taloni, Gianni Pagnini, Sergei Fedotov, Viki Allan, Thomas Andrew Waigh
Publikováno v:
Entropy, Vol 23, Iss 8, p 958 (2021)
Trajectories of endosomes inside living eukaryotic cells are highly heterogeneous in space and time and diffuse anomalously due to a combination of viscoelasticity, caging, aggregation and active transport. Some of the trajectories display switching
Externí odkaz:
https://doaj.org/article/bd3a46df520d4f80acaae47ad2475908
Autor:
Nickolay Korabel, Alessandro Taloni, Gianni Pagnini, Viki Allan, Sergei Fedotov, Thomas Andrew Waigh
Publikováno v:
Scientific Reports. 13
Transport processes of many structures inside living cells display anomalous diffusion, such as endosomes in eukaryotic cells. They are also heterogeneous in space and time. Large ensembles of single particle trajectories allow the heterogeneities to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fc8db592e7fad1ab72339c6303e3a1
https://doi.org/10.1038/s41598-023-35903-0
https://doi.org/10.1038/s41598-023-35903-0
Publikováno v:
Watts Moore, O, Waigh, T, Mendoza, C & Kowalski, A J 2023, ' Characterising the rheology of lamellar gel networks with optical coherence tomography velocimetry ', Journal of Rheology, vol. 67, 589 . https://doi.org/10.1122/8.0000599
Lamellar gel networks based on mixtures of cetostearyl alcohol and a cationic surfactant, cetyl-trimethylammonium chloride, were studied using a combination of rheometry and optical coherence tomography (OCT) velocimetry. Experiments were conducted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2e31941dbad176abfcf136d1cca6e9
https://research.manchester.ac.uk/en/publications/cfb8eded-de61-4517-8329-57a2b2f74ed7
https://research.manchester.ac.uk/en/publications/cfb8eded-de61-4517-8329-57a2b2f74ed7
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207436 (2018)
Intracellular transport of organelles is fundamental to cell function and health. The mounting evidence suggests that this transport is in fact anomalous. However, the reasons for the anomaly is still under debate. We examined experimental trajectori
Externí odkaz:
https://doaj.org/article/2fe355300479413cb194a2300b4ded7b